Category: 1261475-16-4

On January 15, 2015, Azuma, Shuhei; Arimori, Sadayuki; Hasegawa, Nao published a patent.Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene The title of the patent was Tetrazolinone compound, pest control agent containing the compound, and pest control method. And the patent contained the following:

A tetrazolinone compound represented by formula I [Q is a 6-membered aromatic heterocyclic group which may have one or more atoms or groups selected from group P1 (provided that a hetero atom that composes the heterocyclic group is a nitrogen atom, and the number of the nitrogen atom is 1, 2 or 3); R1, R2, R3 and R11 are each a C1-C6 alkyl group, etc., which may have one or more atoms or groups selected from group P2; R4 and R5 are each a hydrogen atom, etc.; R6 is a C1-C6 alkyl group, etc., which may have one or more halogen atoms; R7, R8 and R9 are each a hydrogen atom, etc.; and X is an oxygen atom or sulfur atom.] has good control efficacy on pests. Thus, application of a solution containing 1-[2-[2-methyl-4-(4-methylpyridin-2-yl)phenoxymethyl]phenyl]-4-methyl-1,4-dihydrotetrazol-5-one (preparation given) to rice seedlings significantly decreased lesion due to Magnaporthe grisea. The experimental process involved the reaction of 1-Bromo-3-isocyanato-2-methyl-benzene(cas: 1261475-16-4).Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene

The Article related to tetrazolinone compound preparation pest control agent, phenoxymethylphenyltetrazolinone preparation agrochem fungicide, Agrochemical Bioregulators: Microbial and other aspects.Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 27, 2014, Matsuzaki, Yuichi published a patent.Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene The title of the patent was Plant disease-controlling compositions containing tetrazolinones and QoI compounds, and method for controlling plant diseases. And the patent contained the following:

Title compositions contain tetrazolinones I (n = 0-5; R1 = halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, NO2, cyano; R2 = C1-3 alkyl, C3-4 cycloalkyl, halo, C1-3 alkoxy, C1-2 alkylthio, C2-3 alkenyl, C2-3 alkynyl; wherein the alkyls in R1 and R2 may be halogenated; when n ≥2, then R1 may differ from each other) and ≥1 QoI compounds chosen from azoxystrobin, pyraclostrobin, picoxystrobin, trifloxystrobin, mandestrobin, fluoxastrobin, kresoxim-Me, dimoxystrobin, orysastrobin, metominostrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, triclopyricarb, fenaminstrobin, pyribencarb, famoxadone, and fenamidone. Thus, a mixture of 1-[2-[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxymethyl]-3-chlorophenyl]-4-methyl-1,4-dihydrotetrazol-5-one (3 ppm) plus azoxystrobin (1 ppm) strongly inhibited the growth of Septoria tritici. The experimental process involved the reaction of 1-Bromo-3-isocyanato-2-methyl-benzene(cas: 1261475-16-4).Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene

The Article related to agrochem fungicide tetrazolinone qoi compound, azoxystrobin agrochem fungicide tetrazolinone, Agrochemical Bioregulators: Microbial and other aspects.Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 9, 2015, Matsuzaki, Yuichi; Kurahashi, Makoto published a patent.Product Details of 1261475-16-4 The title of the patent was Plant disease control composition containing tetrazolinone compound and pesticide, and use thereof. And the patent contained the following:

This plant disease control composition is effective in controlling plant diseases, and contains a tetrazolinone compound represented in formula I (R1 = C1-3 alkyl, etc.; R2 = H, etc.; R3 = C1-3 alkyl, etc.; Z1 = C1-3 alkyl; Z2 = C1-2 alkoxy, etc.; Z3 = C1-3 alkyl, etc.) and a pesticide, and ideally, the weight ratio between the tetrazolinone compound and the pesticide is tetrazolinone compound/pesticide = 0.1/1 to 10/1. For example, a composition containing 3 ppm 1-[3-methyl-2-[2-methyl-4-(5-chloro-1,4-dimethyl-1H-pyrazol-3-yl)-phenoxymethyl]-phenyl]-4-methyl-1,4-dihydrotetrazol-5-one and 1 ppm prothioconazole showed high preventive effect to Septoria tritici. The experimental process involved the reaction of 1-Bromo-3-isocyanato-2-methyl-benzene(cas: 1261475-16-4).Product Details of 1261475-16-4

The Article related to plant disease control tetrazolinone pesticide prothioconazole mixture, Agrochemical Bioregulators: Microbial and other aspects.Product Details of 1261475-16-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 9, 2015, Matsuzaki, Yuichi; Kurahashi, Makoto published a patent.SDS of cas: 1261475-16-4 The title of the patent was Plant disease control composition containing tetrazolinone compound and QoI compound, and and use thereof. And the patent contained the following:

This plant disease control composition is effective in controlling plant diseases, and contains a tetrazolinone compound represented in formula I (R1 = C1-3 alkyl, etc.; R2 = H, etc.; R3 = C1-3 alkyl, etc.; Z1 = C1-3 alkyl; Z2 = C1-2 alkoxy, etc.; Z3 = C1-3 alkyl, etc.) and a QoI compound, and ideally, the weight ratio between the tetrazolinone compound and the QoI compound is tetrazolinone compound/QoI compound = 0.1/1 to 10/1. For example, a composition containing 3 ppm 1-[3-methyl-2-[2-methyl-4-(5-chloro-1,4-dimethyl-1H-pyrazol-3-yl)-phenoxymethyl]-phenyl]-4-methyl-1,4-dihydrotetrazol-5-one and 1 ppm azoxystrobin showed high preventive effect to Septoria tritici. The experimental process involved the reaction of 1-Bromo-3-isocyanato-2-methyl-benzene(cas: 1261475-16-4).SDS of cas: 1261475-16-4

The Article related to plant disease control tetrazolinone pesticide azoxystrobin mixture, Agrochemical Bioregulators: Microbial and other aspects.SDS of cas: 1261475-16-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 27, 2014, Matsuzaki, Yuichi published a patent.Application In Synthesis of 1-Bromo-3-isocyanato-2-methyl-benzene The title of the patent was Plant disease-controlling compositions containing tetrazolinones and carboxamides, and method for controlling plant diseases. And the patent contained the following:

Title compositions contain tetrazolinones I (n = 0-5; R1 = halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, NO2, cyano; R2 = C1-3 alkyl, C3-4 cycloalkyl, halo, C1-3 alkoxy, C1-2 alkylthio, C2-3 alkenyl, C2-3 alkynyl; wherein the alkyls in R1 and R2 may be halogenated; when n ≥2, then R1 may differ from each other) and ≥1 carboxamides chosen from bixafen, benzovindiflupyr, fluxapyroxad, penthiopyrad, N-(1,1,3-trimethylindan-4-yl)-1-methyl-3-difluoromethylpyrazole-4-carboxamide, isofetamid, isopyrazam, boscalid, fluopyram, sedaxane, penflufen, flutolanil, mepronil, carboxin, thifluzamide, and furametpyr. Thus, a mixture of 1-[2-[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxymethyl]-3-chlorophenyl]-4-methyl-1,4-dihydrotetrazol-5-one (3 ppm) plus bixafen (1 ppm) strongly inhibited the growth of Septoria tritici. The experimental process involved the reaction of 1-Bromo-3-isocyanato-2-methyl-benzene(cas: 1261475-16-4).Application In Synthesis of 1-Bromo-3-isocyanato-2-methyl-benzene

The Article related to agrochem fungicide tetrazolinone carboxamide wheat, Agrochemical Bioregulators: Microbial and other aspects.Application In Synthesis of 1-Bromo-3-isocyanato-2-methyl-benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 27, 2014, Matsuzaki, Yuichi published a patent.Related Products of 1261475-16-4 The title of the patent was Plant disease-controlling compositions containing tetrazolinones and azoles, and method for controlling plant diseases. And the patent contained the following:

Title compositions contain tetrazolinones I (n = 0-5; R1 = halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, NO2, cyano; R2 = C1-3 alkyl, C3-4 cycloalkyl, halo, C1-3 alkoxy, C1-2 alkylthio, C2-3 alkenyl, C2-3 alkynyl; wherein the alkyls in R1 and R2 may be halogenated; when n ≥2, then R1 may differ from each other) and ≥1 azoles chosen from propiconazole, prothioconazole, triadimenol, prochloraz, penconazole, tebuconazole, flusilazole, diniconazole, bromuconazole, epoxiconazole, difenoconazole, cyproconazole, metconazole, triflumizole, tetraconazole, myclobutanil, fenbuconazole, hexaconazole, fluquinconazole, triticonazole, bitertanol, imazalil, ipconazole, simeconazole, hymexazol, etridiazole, and flutriafol. Thus, a mixture of 1-[2-[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxymethyl]-3-chlorophenyl]-4-methyl-1,4-dihydrotetrazol-5-one (3 ppm) plus prothioconazole (1 ppm) strongly inhibited the growth of Septoria tritici. The experimental process involved the reaction of 1-Bromo-3-isocyanato-2-methyl-benzene(cas: 1261475-16-4).Related Products of 1261475-16-4

The Article related to agrochem fungicide tetrazolinone azole, Agrochemical Bioregulators: Microbial and other aspects.Related Products of 1261475-16-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 30, 2021, Zhang, Weidong; Sun, Qingyan; Zhao, Menghao; Chen, Haomin; Guo, Jingwen; Zhang, Panpan published a patent.Name: 1-Bromo-3-isocyanato-2-methyl-benzene The title of the patent was Preparation of cyclopentene compounds as STAT3 inhibitor for prevention and/or treatment of cell proliferative diseases. And the patent contained the following:

The present invention relates to the preparation of cyclopentene compounds as STAT3 inhibitor for prevention and/or treatment of cell proliferative diseases. In particular, the cyclopentene compound I (wherein, ring A = C6-C10 aryl group or 5-6 membered heteroaryl group and the heteroatom in the 5-6 membered heteroaryl group = one or more of N, O, S and the number of heteroatoms = 1-4; n = 0,1,2,3 or 4; R2 = independently C1-C6 alkyl group, C1-C6 alkyl group -O-, C1-C6 alkyl group -C(=O)-N(R2a)- etc.; R2a and R2b = independently H or C1-C4 alkyl group; L1 = -C(=O)-, -N(R11)-C(=O)-N(R10)-, -C(=O)-N(R12)-, -N(R13)-C(=O)- etc., where R10, R11, R12, R13, R14, R15, R16, R17, R18, R19 and R20 = independently H or C1-C4 alkyl group). Further, (R1 = H, C1-C6 alkyl substituted with one or more substituents Ra, C3-C10 cycloalkyl group, C3-C10 cycloalkyl substituted by one or more substituents Rb, C6-C10 aryl group, C3-C10 aryl substituted by one or more substituents Rc, 5-10 membered heterocycloalkyl etc., and the heteroatom = N, O, S etc., and the number of heteroatoms = 1-3; Ra, Rb, Rc, Rd, Re = independently (R1a R1b) N-C(=O)-, C1-C6 alkyl -O-, C1-C6 alkyl -C(=O)-N(R1c)- or O=). Further, (R1a, R1b and R1c = independently H or C1-C4 alkyl group; alternatively, R2 is connected to C or N in R1-L1 to form a 4-7 membered heterocycloalkyl group together with the atoms connected to ring A; the heteroatoms in the 4-7 membered heterocycloalkyl group = one or more of N, O, S, S(=O) and S(=O)2, and the number of heteroatoms = 1-3; the 4-7 membered heterocycloalkyl group is optionally substituted by the substituents: C1-C4 alkyl group or =O; a carbon atom with * represents a chiral carbon atom, which is in the S configuration, R configuration, or a mixture) or its pharmaceutically acceptable salt was prepared The inventive cyclopentene compounds has selectivity for STAT3 in preliminary activity study, and at the same time, shows a strong inhibitory activity against tumor cell proliferation with a significant killing effect on human cancer cells, especially human breast cancer cell line MDA-MB-231, human prostate cancer cell line PC-3 and human prostate cancer cell line DU-145, therefore it can be used as a series of novel STAT3 inhibitors in the preparation of corresponding novel antitumor drugs for diseases with a good market prospect. The experimental process involved the reaction of 1-Bromo-3-isocyanato-2-methyl-benzene(cas: 1261475-16-4).Name: 1-Bromo-3-isocyanato-2-methyl-benzene

The Article related to cyclopentene compound stat3 inhibitor antitumor agent, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Name: 1-Bromo-3-isocyanato-2-methyl-benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On July 17, 2014, Boruah, Anima; Hosahalli, Subramanya; Panigrahi, Sunil Kumar published a patent.Related Products of 1261475-16-4 The title of the patent was Substituted 2-pyrazinone derivatives as kinase inhibitors. And the patent contained the following:

The present invention provides novel substituted 2-pyrazinone derivatives (I) as protein kinase inhibitors that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting kinase enzyme, more particularly BTK enzyme. The present invention also provides methods for synthesizing and administering the kinase inhibitor compounds The present invention also provides pharmaceutical formulations comprising at least one of the kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The experimental process involved the reaction of 1-Bromo-3-isocyanato-2-methyl-benzene(cas: 1261475-16-4).Related Products of 1261475-16-4

The Article related to btk kinase inhibitor pyrazinone derivative preparation cancer autoimmune inflammation, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Related Products of 1261475-16-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 31, 2014, Ko, Soo Sung; Batt, Douglas A.; Bertrand, Myra Beaudoin; Delucca, George V.; Langevine, Charles M.; Liu, Qingjie; Srivastava, Anurag S.; Watterson, Scott Hunter published a patent.Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene The title of the patent was Preparation of 4-phenylcarbazole-1-carboxamide compounds useful as Bruton’s tyrosine kinase (Btk) inhibitors. And the patent contained the following:

There are disclosed carbazolecarboxamide compounds of formula [I; Q = Q1, Q2, Q3, or Q4; R1 = C(CH3)2OH, NHC(O)C(CH3)3, N(CH3)2, or CH2Rd; R2 = Cl or CH3; R3 = H, F, or CH3; Ra = H or CH3; Rb = H, F, Cl, or OCH3; Rc = H or F; Rd = OH, OCH3, NHC(O)CH3, or pyrrolidin-1-yl] or salts thereof. These compounds are inhibitors of kinases, in particular Bruton’s tyrosine kinase (Btk) and are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and chronic inflammatory diseases. Thus, 4-bromo-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide was coupled with 5-chloro-2-[2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-pyrido[1,2-c]pyrimidine-1,3(2H)-dione in the presence of Pd2(dppf).CH2Cl2adduct and Cs2CO3 in THF under argon at 45° for 3.5 h to give 39% 4-[3-(5-chloro-1,3-dioxo-1H-pyrido[1,2-c]pyrimidin-2(3H)-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide as a mixture of 4 diastereomers which was separated by chiral super-critical fluid chromatog. to give 4-[3-(R)-(5-Chloro-1,3-dioxo-1H-pyrido[1,2-c]pyrimidin-2(3H)-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide (II) and 4-[3-(S)-(5-chloro-1,3-dioxo-1H-pyrido[1,2-c]pyrimidin-2(3H)-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide (III). III showed IC50 of 0.41 and 1,000 nM against human recombinant Bruton’s tyrosine kinase (Btk) and Jak2 tyrosine kinase, resp. The experimental process involved the reaction of 1-Bromo-3-isocyanato-2-methyl-benzene(cas: 1261475-16-4).Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene

The Article related to carbazolecarboxamide preparation bruton tyrosine kinase btk kinase inhibitor, phenylcarbazolecarboxamide preparation kinase inhibitor, autoimmune disease chronic inflammatory disease treatment prevention phenylcarbazolecarboxamide preparation and other aspects.Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 31, 2014, Ko, Soo Sung; Batt, Douglas A.; Bertrand, Myra Beaudoin; Delucca, George V.; Langevine, Charles M.; Liu, Qingjie; Srivastava, Anurag S.; Watterson, Scott Hunter published a patent.Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene The title of the patent was Preparation of 4-phenylcarbazole-1-carboxamide compounds useful as Bruton’s tyrosine kinase (Btk) inhibitors. And the patent contained the following:

There are disclosed carbazolecarboxamide compounds of formula [I; Q = Q1, Q2, Q3, or Q4; R1 = C(CH3)2OH, NHC(O)C(CH3)3, N(CH3)2, or CH2Rd; R2 = Cl or CH3; R3 = H, F, or CH3; Ra = H or CH3; Rb = H, F, Cl, or OCH3; Rc = H or F; Rd = OH, OCH3, NHC(O)CH3, or pyrrolidin-1-yl] or salts thereof. These compounds are inhibitors of kinases, in particular Bruton’s tyrosine kinase (Btk) and are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and chronic inflammatory diseases. Thus, 4-bromo-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide was coupled with 5-chloro-2-[2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-pyrido[1,2-c]pyrimidine-1,3(2H)-dione in the presence of Pd2(dppf).CH2Cl2adduct and Cs2CO3 in THF under argon at 45° for 3.5 h to give 39% 4-[3-(5-chloro-1,3-dioxo-1H-pyrido[1,2-c]pyrimidin-2(3H)-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide as a mixture of 4 diastereomers which was separated by chiral super-critical fluid chromatog. to give 4-[3-(R)-(5-Chloro-1,3-dioxo-1H-pyrido[1,2-c]pyrimidin-2(3H)-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide (II) and 4-[3-(S)-(5-chloro-1,3-dioxo-1H-pyrido[1,2-c]pyrimidin-2(3H)-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide (III). III showed IC50 of 0.41 and 1,000 nM against human recombinant Bruton’s tyrosine kinase (Btk) and Jak2 tyrosine kinase, resp. The experimental process involved the reaction of 1-Bromo-3-isocyanato-2-methyl-benzene(cas: 1261475-16-4).Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene

The Article related to carbazolecarboxamide preparation bruton tyrosine kinase btk kinase inhibitor, phenylcarbazolecarboxamide preparation kinase inhibitor, autoimmune disease chronic inflammatory disease treatment prevention phenylcarbazolecarboxamide preparation and other aspects.Recommanded Product: 1-Bromo-3-isocyanato-2-methyl-benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary