Related Products of 1260850-70-1, A common heterocyclic compound, 1260850-70-1, name is 3-Bromoimidazo[1,2-b]pyridazin-6-ylamine, molecular formula is C6H5BrN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-bromoimidazo[l,2-b]pyridazin-6-amine (1.8 g, 7.0 mmol), 2-fluorophenylboronic acid (1.33 g,7.0 mmol), Cs2C03 (4.57 g, 14.0 mmol) and Pd[PPh3]4 (0.4 g,0.35 mmol) were dissolved in a mixture solvent (dioxane:water:ethanol = 4: 1 : 10 drops). The reaction was stirred at 100 C for about 4 h. The mixture was purified on a silica gel column to give 3- (2-fluorophenyl)imidazo[l,2-b]pyridazin-6-amine (1.05 g,55%). MS (ESI) calcd for
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; BLUM, Charles, A.; SPRINGER, Stephanie, K.; VU, Chi, B.; WO2013/59589; (2013); A1;,
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