Category: 123158-68-9

Volkov, Oleg A. published the artcileSpecies-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase, SDS of cas: 123158-68-9, the main research area is pyrimidineamine preparation trypanosomicide Trypanosoma adenosylmethionine decarboxylase inhibitor.

New therapeutic options are needed for treatment of human African trypanosomiasis (HAT) caused by protozoan parasite Trypanosoma brucei. S-Adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the polyamine pathway of T. brucei. Previous attempts to target this enzyme were thwarted by the lack of brain penetration of the most advanced series. Herein, the authors describe a T. brucei AdoMetDC inhibitor series based on a pyrimidineamine pharmacophore that the authors identified by target-based high-throughput screening. The pyrimidineamines showed selectivity for T. brucei AdoMetDC over the human enzyme, inhibited parasite growth in whole-cell assay, and had good predicted blood-brain barrier penetration. The medicinal chem. program elucidated structure-activity relationships within the series. Features of the series that were required for binding were revealed by determining the x-ray crystal structure of TbAdoMetDC bound to one analog. The pyrimidineamine series provides a novel starting point for an anti-HAT lead optimization.

Journal of Medicinal Chemistry published new progress about Blood-brain barrier. 123158-68-9 belongs to class bromides-buliding-blocks, name is 3-Bromo-5-ethylaniline, and the molecular formula is C8H10BrN, SDS of cas: 123158-68-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Zenan published the artcileHydroxyl Assisted Rhodium Catalyst Supported on Goethite Nanoflower for Chemoselective Catalytic Transfer Hydrogenation of Fully Converted Nitrostyrenes, SDS of cas: 123158-68-9, the main research area is hydroxyl assisted rhodium supported goethite nanoflower catalyst preparation; aniline chemoselective green preparation; nitrostyrene hydrazine hydrate transfer hydrogenation rhodium catalyst; nitroarene hydrazine hydrate transfer hydrogenation rhodium catalyst.

A flower-like Rh/α-FeOOH catalyst was used for the chemoselective hydrogenation of nitrostyrenes/nitroarenes to anilines. This catalyst did not showed desirable selectivity for the anilines, but also exhibits the inertness to various other reducible groups over wide reaction duration. The catalytic selectivity for the reduction of the nitro group towards vinyl group was investigated by the control experiments and FT-IR anal. The abundant hydroxyl groups in the α-FeOOH might contribute to the improvement of catalytic activity and selectivity. Furthermore, the catalyst exhibited excellent stability and kept its catalytic performance even after 6 cycles.

Advanced Synthesis & Catalysis published new progress about Anilines Role: SPN (Synthetic Preparation), PREP (Preparation). 123158-68-9 belongs to class bromides-buliding-blocks, name is 3-Bromo-5-ethylaniline, and the molecular formula is C8H10BrN, SDS of cas: 123158-68-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary