Category: 1219741-50-0

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Lewis acid-catalyzed [3+2] coupling of indoles with quinone monoacetals or quinone imine ketal.Computed Properties of C9H8BrN.

The one-pot synthesis of benzofuroindolines and tetrahydroindolo[2,3-b]indoles was accomplished through a mild and concise [3+2] coupling of indoles and quinone monoacetals or quinone imine ketal promoted by a Lewis acid. A wide variety of benzofuroindolines and tetrahydroindolo[2,3-b]indoles were prepared in moderate to good yields. The structures of the products were determined by spectroscopic anal. and their relative configuration was confirmed by single crystal x-ray diffraction anal. of tetrahydroindolo[2,3-b]indole derivative I [triclinic, space group P-1, a 9.0872(4), b 10.6606(4), c 11.1102(5) Å, α 87.728(5), β 81.405(4), γ 81.279(4)°, V 1051.75(8) Å3, Z 2]. The detailed crystallog. data were deposited at the Cambridge Crystallog. Data Center as supplementary publication number CCDC 983833.

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Shi, Xiaolin; Li, Xiaowei; Ma, Lina; Shi, Dayong published an article about the compound: 6-Bromo-3-methyl-1H-indole( cas:1219741-50-0,SMILESS:CC1=CNC2=C1C=CC(Br)=C2 ).Application of 1219741-50-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1219741-50-0) through the article.

An efficient copper-catalyzed oxidative trifluoromethylation of indoles I (R1 = H, Boc, Bn, Bz; R2 = Me, cyclohexyl, CH2C(O)CH3, CH2CN, etc.; R3 = H, 4-F, 5-MeO, 6-Cl, 7-Br, etc.) with low-cost CF3SO2Na via C-H activation has been described. Notably, the use of a base is crucial for the trifluoromethylation of indoles I. This reaction proceeds efficiently in good to excellent yields and is tolerance of a broad range of functional groups. Furthermore, melatonin, a medicine for sleep disorders, is converted to its 2-CF3 analog in 68% yield. Studies of possible reaction pathways suggest that this reaction proceeds through a radical process.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Enantioselective Friedel-Crafts C2-alkylation of 3-substituted indoles with trifluoropyruvates and cyclic N-sulfonyl α-ketiminoesters, the main research direction is indolyl trifluoromethyl hydroxy ester preparation enantioselective; indole trifluoropyruvate Friedel Crafts enantioselective alkylation; dihydro benzoisothiazole carboxylate indolyl preparation enantioselective; cyclic sulfonyl ketimino ester indole Friedel Crafts alkylation enantioselective.SDS of cas: 1219741-50-0.

Enantioselective Friedel-Crafts C2-alkylation reactions of 3-substituted indoles I (R1 = H, 5-MeO, 6-F, etc.; R2 = Me, Ph) with trifluoropyruvates F3CC(O)CO2R3 (R3 = Me, Et) and cyclic N-sulfonyl α-ketiminoesters II (R4 = H, 4-Cl, 4,7-F2, 6-Me, etc.; R5 = Me, Et, i-Pr) were developed by using the complexes of Cu(OTf)2 or Zn(OTf)2 with chiral bisoxazoline ligands. A range of chiral indole-containing trifluoromethylated α-hydroxy esters III and cyclic α-amino esters bearing quaternary stereogenic centers IV was prepared, resp., in good yields and with excellent enantioselectivities (up to 99% ee) under mild conditions.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Organic Letters called Organocatalytic Formal (3+2) Cycloaddition toward Chiral Pyrrolo[1,2-a]indoles via Dynamic Kinetic Resolution of Allene Intermediates, Author is Bai, Jian-Fei; Zhao, Lulu; Wang, Fang; Yan, Fachao; Kano, Taichi; Maruoka, Keiji; Li, Yuehui, which mentions a compound: 1219741-50-0, SMILESS is CC1=CNC2=C1C=CC(Br)=C2, Molecular C9H8BrN, Application In Synthesis of 6-Bromo-3-methyl-1H-indole.

The chiral phosphoric acid catalyzed formal (3+2) cycloaddition of 3-substituted 1H-indoles and propargylic alcs. containing a functional directing group (p-NHAc or p-OH) was reported. A straightforward method to synthesize chiral pyrrolo[1,2-a]indole bearing a tetrasubstituted carbon stereocenter was represented. The reaction proceeded smoothly with a wide array of substrate tolerance to deliver various chiral pyrrolo[1,2-a]indoles in up to 93% yield and 98% ee. The utility of this method is highlighted by the diverse transformations of the products into various indole derivatives

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1219741-50-0, is researched, Molecular C9H8BrN, about Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes, the main research direction is functionalized arene heteroarene preparation; arene heteroarene functionalization mesoporous graphitic carbon nitride photoredox catalyst.Safety of 6-Bromo-3-methyl-1H-indole.

In photoredox catalysis, an excited chromophore typically activates a single reactant either by oxidizing or reducing it. Ghosh et al. used a semiconductor catalyst to activate two reactants at once by quenching both an excited electron and the residual pos. hole (see the Perspective by Swift). As such, two different reactive carbon or halide fragments could be appended to sep. sites on an aryl ring. The catalyst also tolerated strong nucleophiles such as cyanide and could be recovered easily and reused.

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Application of 1219741-50-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Chiral Diphosphine-Palladium-Catalyzed Sequential Asymmetric Double-Friedel-Crafts Alkylation and N-Hemiketalization for Spiro-polycyclic Indole Derivatives. Author is Li, Nai-Kai; Zhang, Jun-Qi; Sun, Bing-Bing; Li, Hai-Yan; Wang, Xing-Wang.

An efficient cascade asym. Friedel-Crafts alkylation/N-hemiketalization/Friedel-Crafts alkylation reaction of 3-alkylindoles with oxindolyl β,γ-unsaturated α-ketoesters has been developed in the presence of a chiral diphosphine-palladium(II) catalyst. A series of enantiomerically enriched spiro-polycyclic indole derivatives, e.g. I, have been constructed in high yields with excellent enantioselectivities and diastereoselectivities.

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Bromide – Wikipedia,
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Recommanded Product: 6-Bromo-3-methyl-1H-indole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Formal [3+2] cycloadditions via indole activation: a route to pyrroloindolines and furoindolines. Author is Wang, Ya-Ni; Li, Tian-Ren; Zhang, Mao-Mao; Cheng, Bei-Yi; Lu, Liang-Qiu; Xiao, Wen-Jing.

Here, we describe a novel [3+2] cycloaddition of 3-substituted indoles with vinyl aziridines and vinyl epoxides that provides a straightforward approach to pyrroloindolines and furoindolines bearing vinyl groups (up to 96% yield and 9:1 dr). In contrary to previous reports involving Lewis acid activation, this work reports successful reactions based on the activation of indole using tBuOK and BEt3 (triethylborane), thereby preserving the free N-H group on indoles. In addition, a gram-scale reaction and a ring-closing metathesis reaction are performed to provide good demonstrations of the synthetic utility of this approach.

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Bromide – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Construction of 9H-Pyrrolo[1,2-a]indoles by a Copper-Catalyzed Friedel-Crafts Alkylation/Annulation Cascade Reaction.Recommanded Product: 1219741-50-0.

An efficient and concise Cu(OTf)2-catalyzed Friedel-Crafts alkylation/annulation cascade reaction of substituted indoles with 1,2-dicarbonyl-3-enes has been established. This reaction uses readily available starting materials and is operationally simple, thus representing a practical method for the construction of diverse 9H-pyrrolo[1,2-a]indoles bearing a carbonyl group.

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Bromide – Wikipedia,
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