Category: 1219741-50-0

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lu, Chen; Zhang, Qiang; Chen, Xin researched the compound: 6-Bromo-3-methyl-1H-indole( cas:1219741-50-0 ).Name: 6-Bromo-3-methyl-1H-indole.They published the article 《New method for synthesis of EZH2 methyltransferase inhibitor GSK126》 about this compound( cas:1219741-50-0 ) in Synthetic Communications. Keywords: EZH2 methyltransferase inhibitor GSK126. We’ll tell you more about this compound (cas:1219741-50-0).

GSK126 is a potent small-mol. inhibitor of S-adenosyl-methionine-competitive EZH2 methyltransferase and has the potential to be used clin. for preventing unwanted histone methylation of tumor suppressor genes. In this article, the authors describe a new synthetic route that has been developed for synthesizing the title compound through nine steps, starting from 2,5-dibromobenzoic acid. This synthetic method is economical and suitable for multigram-scale preparation of GSK126 and related N-alkylated indole derivatives

《New method for synthesis of EZH2 methyltransferase inhibitor GSK126》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Bromo-3-methyl-1H-indole)Name: 6-Bromo-3-methyl-1H-indole.

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Zhang, Lvye; Wu, Binqiang; Chen, Zhangtao; Hu, Jinjin; Zeng, Xiaofei; Zhong, Guofu published the article 《Chiral phosphoric acid catalyzed enantioselective N-alkylation of indoles with in situ generated cyclic N-acyl ketimines》. Keywords: isoindolinylindole preparation enantioselective chemoselective; indole hydroxyisoindolinone phosphoric acid catalyst alkylation.They researched the compound: 6-Bromo-3-methyl-1H-indole( cas:1219741-50-0 ).Application In Synthesis of 6-Bromo-3-methyl-1H-indole. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1219741-50-0) here.

A chiral SPINOL derived phosphoric acid-catalyzed asym. N-alkylation reaction of indoles with cyclic α-diaryl-substituted N-acyl imines, which are generated in-situ from 3-aryl 3-hydroxyisoindolinones, was demonstrated. The transformation proceeded smoothly with a broad range of indoles and isoindolinone alcs. A variety of indole derived N-alkylated tetrasubstituted chiral aminals were afforded in moderate to good yields (50-79%) with excellent enantioselectivities (up to 98% ee).

《Chiral phosphoric acid catalyzed enantioselective N-alkylation of indoles with in situ generated cyclic N-acyl ketimines》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Bromo-3-methyl-1H-indole)Application In Synthesis of 6-Bromo-3-methyl-1H-indole.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1219741-50-0, is researched, SMILESS is CC1=CNC2=C1C=CC(Br)=C2, Molecular C9H8BrNJournal, ChemCatChem called Chiral Broensted Acid-Catalyzed Asymmetric 1,4-Addition of Benzofuran-Derived Azadienes with 3-Substituted indoles, Author is Zhou, Ji; Li, Tian-Zhen; Sun, Yu-Wen; Du, Bai-Xiang; Tan, Wei; Shi, Feng, the main research direction is methyl indolyl aryl benzofuranyl benzenesulfonamide preparation enantioselective; benzofuranyl azadiene indole asym addition chiral Bronsted acid catalyst.Safety of 6-Bromo-3-methyl-1H-indole.

A chiral phosphoric acid-catalyzed asym. 1,4-addition of benzofuran-derived azadienes I (R = H, 3-F, 4-Cl, 3-Me, etc.) with 3-substituted indoles II (R1 = Me, Et, Bn, Ph, 2-thienyl; R2 = H, 5-Cl, 6-Br, 7-Me, etc.) has been established, which offered enantioenriched tri(hetero)arylmethane products (S)-III in generally good yields (up to 98%) and high enantioselectivities (up to 99:1 er). This reaction has not only realized the application of chiral phosphoric acid as a competent catalyst in the asym. transformations of benzofuran-derived azadienes I, but also has accomplished the task of developing chiral Bronsted acid-catalyzed asym. 1,4-additions of benzofuran-derived azadienes I, which will enrich the research contents of chiral phosphoric acid catalysis and the chem. of benzofuran-derived azadienes I.

《Chiral Broensted Acid-Catalyzed Asymmetric 1,4-Addition of Benzofuran-Derived Azadienes with 3-Substituted indoles》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Bromo-3-methyl-1H-indole)Safety of 6-Bromo-3-methyl-1H-indole.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Bromo-3-methyl-1H-indole( cas:1219741-50-0 ) is researched.Computed Properties of C9H8BrN.Zhao, Sen; Li, Chunpu; Xu, Bin; Liu, Hong published the article 《Cp*Rh (III)-catalyzed C-H 3,3-difluoroallylation of indoles and N-iodosuccinimide-mediated cyclization for the synthesis of fluorinated 3,4-dihydropyrimido[1,6-a]indol-1(2H)-one derivatives》 about this compound( cas:1219741-50-0 ) in Youji Huaxue. Keywords: alkoxycarbamoylindole bromodifluoropropene rhodium catalyst difluoroallylation; difluoroallyl alkoxycarbamoylindole preparation iodosuccinimide promoter heterocyclization; difluoroiodomethyl alkoxy pyrimidoindolone preparation. Let’s learn more about this compound (cas:1219741-50-0).

A mild and facile two-step strategy was developed for the synthesis of fluorinated 3,4-dihydropyrimido[1,6-a]indol-1(2H)-ones through Cp*Rh (III)-catalyzed C-H 3,3-difluoroallylation and N-iodosuccinimide (NIS)-mediated cyclization. This strategy featured broad synthetic generality, unique versatility and high efficiency, which provided a potential tool for the construction of fluorine-containing heterocycles for drug discovery.

Different reactions of this compound(6-Bromo-3-methyl-1H-indole)Computed Properties of C9H8BrN require different conditions, so the reaction conditions are very important.

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Computed Properties of C9H8BrN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Cu-Catalyzed Dimerization of Indole Derived Oxime Acetate for Synthesis of Biimidazo[1,2-a]indoles. Author is Xie, Tao; Sui, Qi-Bang; Qin, Lu-Zhe; Wen, Xiaoan; Sun, Hongbin; Xu, Qing-Long; Zhen, Le.

A copper-mediated cyclization and dimerization of indole derived oxime acetate was developed to generate a series of biimidazo[1,2-a]indole scaffolds with two contiguous stereogenic quaternary carbons in one step.

The article 《Cu-Catalyzed Dimerization of Indole Derived Oxime Acetate for Synthesis of Biimidazo[1,2-a]indoles》 also mentions many details about this compound(1219741-50-0)Computed Properties of C9H8BrN, you can pay attention to it, because details determine success or failure

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors.Computed Properties of C9H8BrN.

In previous work, we described 6-6′-bisindole compounds targeting a hydrophobic pocket on the N-heptad repeat region of viral glycoprotein-41 as effective inhibitors of HIV-1 fusion. Two promising compounds with sub-micromolar IC50’s contained a benzoic acid group and a benzoic acid ester attached at the two indole nitrogens. Here we have conducted a thorough structure-activity relationship (SAR) study evaluating the contribution of each of the ring systems and various substituents to compound potency. Hydrophobicity, polarity and charge were varied to produce 35 new compounds that were evaluated in binding, cell-cell fusion and viral infectivity assays. We found that (a) activity based solely on increasing hydrophobic content plateaued at ∼ 200 nM; (b) the bisindole scaffold surpassed other heterocyclic ring systems in efficacy; (c) a polar interaction possibly involving Gln575 in the pocket could supplant less specific hydrophobic interactions; and (d) the benzoic acid ester moiety did not appear to form specific contacts with the pocket. The importance of this hydrophobic group to compound potency suggests a mechanism whereby it might interact with a tertiary component during fusion, such as membrane. A promising small mol. 10b with sub-μM activity was discovered with mol. weight <500 da and reduced logP compared to earlier compounds The work provides insight into requirements for small mol. inhibition of HIV-1 fusion. Although many compounds look similar to this compound(1219741-50-0)Computed Properties of C9H8BrN, numerous studies have shown that this compound(SMILES:CC1=CNC2=C1C=CC(Br)=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Bromide – Wikipedia,
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Quality Control of 6-Bromo-3-methyl-1H-indole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Tandem Carbenoid C-H Functionalization/Conia-ene Cyclization of N-Propargyl Indoles Generates Pyrroloindoles under Cooperative Rh(II)/Zn(II) Catalysis. Author is Bhat, Aabid H.; Alavi, Sima; Grover, Huck K..

The decomposition of diazodicarbonyl compounds in the presence of various metal catalysts has become a reliable method for the functionalization of indoles via carbenoid intermediates. Exploiting the nucleophilic reactivity of the in situ generated malonic ester product formed, we herein report a tandem C-H functionalization/Conia-ene cyclization of N-alkyne tethered indoles. This double functionalization of diazodicarbonyls generates a range of pyrrolo[1,2-a]-, pyrido[1,2-a]-, and azepino[1,2-a]indole products with good synthetic efficiency.

In some applications, this compound(1219741-50-0)Quality Control of 6-Bromo-3-methyl-1H-indole is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Name: 6-Bromo-3-methyl-1H-indole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about A three-component iodine-catalyzed oxidative coupling reaction: a heterodifunctionalization of 3-methylindoles. Author is Zhang, Wei; Xiang, Shiqun; Fan, Weibin; Jin, Jiang; Li, Yinghua; Huang, Deguang.

A metal-free method for the synthesis of heterodifunctional indole derivatives was developed through TBHP/KI-mediated oxidative coupling. The reaction constructed C-O and C-C bonds in succession with the help of tert-Bu peroxy radicals generated by the TBHP/KI catalytic system, enabling the direct realization of the heterodifunctionalization of indole in one pot. The product of this reaction was a novel heterodifunctional compound This work might provided a new effective method for the synthesis of polycyclic indole compounds

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Electric Literature of C9H8BrN. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Chalcogen-Chalcogen Bonding Catalysis Enables Assembly of Discrete Molecules. Author is Wang, Wei; Zhu, Haofu; Liu, Shuya; Zhao, Zhiguo; Zhang, Liang; Hao, Jingcheng; Wang, Yao.

Despite the observation of noncovalent interactions between chalcogen atoms in X-ray crystal structures, catalysis that harnesses the power of such chalcogen-chalcogen bonding interactions to produce advanced mols. remains an unresolved problem. Here, we show that a class of extraordinary chalcogen-bonding catalysts enables assembly of discrete small mols. including three β-ketoaldehydes and one indole, leading to the construction of N-heterocycles in a highly efficient manner. The strong activation ability of these rationally designed catalysts provides a general solution to the intrinsic limitations of chalcogen bonding catalysis.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Bromo-3-methyl-1H-indole(SMILESS: CC1=CNC2=C1C=CC(Br)=C2,cas:1219741-50-0) is researched.Related Products of 60827-45-4. The article 《Facile synthesis of 9H-pyrrolo[1,2-a]indoles via Bronsted acid catalyzed cascade reactions》 in relation to this compound, is published in Chemical Communications (Cambridge, United Kingdom). Let’s take a look at the latest research on this compound (cas:1219741-50-0).

An efficient Bronsted acid catalyzed Friedel-Crafts alkenylation/1,6-addition/condensation cascade reaction has been developed. This protocol enables effective access to various highly functionalized 9H-pyrrolo[1,2-a]indoles I (R1 = Bu, 3-chlorophenyl, thiophen-2-yl, etc.; R2 = Me, thiophen-2-yl, naphthalen-1-yl, etc.; R3 = H, 7-Me, 8-MeO, 6-F, etc.; R4 = Me, phenyl; R5 = H, 6-Cl, 7-MeO, etc.) in moderate to high yields. Mechanistic studies indicate that the in situ vinylogous reactivity intermediate might be formed in the catalytic system.

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