Related Products of 121086-19-9,Some common heterocyclic compound, 121086-19-9, name is 4-Bromo-N-isopropylaniline, molecular formula is C9H12BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N-(4-Bromophenyl)-N-(2-propyl)-3-methyl-2-butenamide Compound 5 A solution of 3,3-dimethylacryloyl chloride (5.56 mL, 50 mmol) in 120 mL of chloroform was added to a solution of 4-bromo-N-(2-propyl)-aniline (Compound 4, 10.4 g, 48.5 mmol) in 400 mL of chloroform over 5 minutes. The reaction mixture was then refluxed overnight. After cooling to room temperature, the reaction mixture was washed with 5% HCl (1*150 mL), saturated, aqueous sodium bicarbonate (1*150 mL) and brine (1*150 mL). The organic phase was dried over anhydrous sodium sulfate and the solvent evaporated in vacuo to afford 13.8 g (96%) of the title compound as a brown solid. 1 H-NMR (300 MHz, CDCl3): d 1.05(d, J=6.8 Hz, 6H), 1.63(s, 3H), 2.08(s, 3H), 4.98(m, 1H), 5.22(br s, 1H), 6.95(d, J=8.5 Hz, 2H), 7.51(d, J=8.6 Hz, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-N-isopropylaniline, its application will become more common.
Reference:
Patent; Allergan Sales, Inc.; US6048873; (2000); A;,
Bromide – Wikipedia,
bromide – Wiktionary