Category: 1195-33-1

Adding a certain compound to certain chemical reactions, such as: 1195-33-1, name is 4-Bromobenzenesulfinic acid, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1195-33-1, Safety of 4-Bromobenzenesulfinic acid

(a) The 4-(4-bromophenylsulphonyl)-5-methyl-1,2-benzenediol used in the above Example is obtained by oxidative condensation of 76.0 g of p-bromobenzenesulphinic acid (obtained from p-bromobenzenesulphochloride by reduction with sodium sulphite) with 53.0 g of 4-methyl-1,2-benzenediol in a manner analogous to that described in Example 5a), in the form of colourless crystals having a melting point of 190-191.5 (from chloroform).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromobenzenesulfinic acid, and friends who are interested can also refer to it.

Reference:
Patent; Ciba-Geigy AG; US4600709; (1986); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 1195-33-1,Some common heterocyclic compound, 1195-33-1, name is 4-Bromobenzenesulfinic acid, molecular formula is C6H5BrO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To an oven-dried 3-neck round-bottom flask (10 mL) equipped with a stir bar were added the olefin (0.50 mmol), sulfinic acid (1.25 mmol), nBu4NBF4 (82.3 mg, 0.25 mmol), and acetonitrile (10 mL). The flask was equipped with a platinum electrode (1.0 cm ×1.0 cm × 0.3 mm) and a graphite rod electrode. The reaction mixture was stirred and electrolyzed at a constant current (10 mA) at room temperature for 4.5 h. Next, the reaction mixture was concentrated, and the residue was purified by silica gel chromatography to afford the pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromobenzenesulfinic acid, its application will become more common.

Reference:
Article; Zhang, Zhefan; Yan; Ma, Dengke; Sun, Jianwei; Chinese Chemical Letters; vol. 30; 8; (2019); p. 1509 – 1511;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 1195-33-1, A common heterocyclic compound, 1195-33-1, name is 4-Bromobenzenesulfinic acid, molecular formula is C6H5BrO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of alkynyliodine 1 (0.1 mmol), sulfinic acid 2 (0.2 mmol) in DME (2 mL) at room temperature under air. The reaction vessel was sealed and allowed to stir for 12 h at 100 C. After completion of the reaction, the resulting mixture was concentrated under vacuum and the residue was purified by flash column chromatography using a mixture of petroleum ether and ethyl acetate as eluent to give the desired products 3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wang, Leilei; Wei, Wei; Yang, Daoshan; Cui, Huanhuan; Yue, Huilan; Wang, Hua; Tetrahedron Letters; vol. 58; 51; (2017); p. 4799 – 4802;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 1195-33-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1195-33-1 name is 4-Bromobenzenesulfinic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A sealable reaction tube equipped with a magnetic stirrer bar was charged with 2-(allyloxy)benzaldehyde (0.2mmol), benzenesulfinic acid (3.0 equiv.), Na2-Eosin Y (4 mol%), K2S2O8 (3.0 equiv.), DMF_H2O=1:1 (2 ml), 8W blue. The reaction vessel was carried out room temperature. After completion, it was diluted with ethylacetate, washed with water. After the solvent was removed under reduced pressure, the residue was purified bycolumn chromatography on silica gel to afford the corresponding product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromobenzenesulfinic acid, and friends who are interested can also refer to it.

Reference:
Article; Chen, De-Mao; Han, Qing-Qing; Li, Guang-Hui; Sun, Yuan-Yuan; Wang, Zu-Li; Xu, Xin-Ming; Yu, Xian-Yong; Chinese Chemical Letters; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1195-33-1, name is 4-Bromobenzenesulfinic acid, A new synthetic method of this compound is introduced below., Computed Properties of C6H5BrO2S

Thionyl chloride (0.53 ml_) is added to an ice-cooled solution of 4- bromobenzenesulfinic acid (400 mg) in dichloromethane (15 ml_) under an argon atmosphere. The reaction mixture is stirred for 2 h at 0C, warmed to room temperature, and stirred for an additional 30 min. The mixture is concentrated and the residue is co-evaporated twice with toluene to give crude 4-bromobenzenesulfinic chloride, which is dissolved in tetrahydrofuran (3 ml_) and cooled to -78 C. n-Butyllithium (1 .6 M in hexane; 2.26 ml_) is added to 2,2,2-trifluoroacetamide (205 mg) in tetrahydrofuran (3 ml_) at -78 C and the reaction mixture is stirred for 10 min. The mixture is added to the 4-bromobenzenesulfinic chloride solution at -78 C and the reaction mixture is stirred for 1 h. The cooling bath is removed and the reaction is quenched by addition of water and brine. The aqueous layer is extracted with ethyl acetate and the combined extracts are washed with brine and concentrated in vacuo to give the title compound which is used for the next step without further purification. LC (method 1 ): tR = 0.92 min; Mass spectrum (ESI+): m/z = 314 [M-H]

The synthetic route of 1195-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LANGKOPF, Elke; BLUM, Andreas; (89 pag.)WO2016/23789; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1195-33-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1195-33-1 as follows.

General procedure: A sealable reaction tube equipped with a magnetic stirrer bar was charged with 2-(allyloxy)benzaldehyde (0.2mmol), benzenesulfinic acid (3.0 equiv.), Na2-Eosin Y (4 mol%), K2S2O8 (3.0 equiv.), DMF_H2O=1:1 (2 ml), 8W blue. The reaction vessel was carried out room temperature. After completion, it was diluted with ethylacetate, washed with water. After the solvent was removed under reduced pressure, the residue was purified bycolumn chromatography on silica gel to afford the corresponding product.

According to the analysis of related databases, 1195-33-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, De-Mao; Han, Qing-Qing; Li, Guang-Hui; Sun, Yuan-Yuan; Wang, Zu-Li; Xu, Xin-Ming; Yu, Xian-Yong; Chinese Chemical Letters; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary