Category: 1193389-40-0

Synthetic Route of 1193389-40-0, The chemical industry reduces the impact on the environment during synthesis 1193389-40-0, name is 1-(4-Bromophenyl)cyclobutanamine hydrochloride, I believe this compound will play a more active role in future production and life.

The free base of commercially available [1 -(4-bromo-phenyl)-cyclobutyl]-amine hydrochloride [CAS 1 193389-40-0] (8.99 g, 34.24 mmol) was prepared as follows: (8.99 g, 34.24 mmol) of the hydrochloride salt was taken up in DCM and washed sequentially with aqueous sodium bicarbonate and water and the organic portion was tried and concentrated.The crude amine was taken up in dry THF (120 mL) and diisopropylethylamine (17.62 mL, 102.71 mmol) under nitrogen and a solution of di-tert-butyldicarbonate (8.22 g, 37.66 mmol) in THF (20 mL) was added. The reaction was stirred at rt overnight. The mixture was partitioned between EtOAc and water and the extracted organic phase was washed with brine and concentrated in vacuo to give the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-Bromophenyl)cyclobutanamine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; INCE, Stuart; HAEGEBARTH, Andrea; POLITZ, Oliver; NEUHAUS, Roland; BOeMER, Ulf; SCOTT, William; WO2012/7345; (2012); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 1193389-40-0, These common heterocyclic compound, 1193389-40-0, name is 1-(4-Bromophenyl)cyclobutanamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The free base of commercially available [1 -(4-bromo-phenyl)-cyclobutyl]-amine hydrochloride [CAS 1 193389-40-0] (8.99 g, 34.24 mmol) was prepared as follows: (8.99 g, 34.24 mmol) of the hydrochloride salt was taken up in DCM and washed sequentially with aqueous sodium bicarbonate and water and the organic portion was dried and concentrated.

The synthetic route of 1193389-40-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; INCE, Stuart; REHWINKEL, Hartmut; HAEGEBARTH, Andrea; POLITZ, Oliver; NEUHAUS, Roland; BOeMER, Ulf; WO2012/7416; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

1193389-40-0, name is 1-(4-Bromophenyl)cyclobutanamine hydrochloride, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1193389-40-0

Intermediate AN-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)benzenesulfonamideTo a solution of 1-(4-bromophenyl)cyclobutanamine, HCl (845 mg, 3.22 mmol) in DMF (10 mL), was added diisopropylethylamine (1.69 mL, 9.66 mmol) and 4-(difluoromethoxy)benzene-1-sulfonyl chloride (0.529 mL, 3.22 mmol). The reaction mixture was then stirred at r.t., overnight. This mixture was then used, as is, in the following experiment.

The synthetic route of 1193389-40-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Squibb Company; US2011/207749; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary