Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1171381-49-9, name is (4-Bromo-2-methylphenyl)methanamine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: (4-Bromo-2-methylphenyl)methanamine hydrochloride
[00371] Step 1. To a stirred mixture of (4-bromo-2-methylphenyl)methyl amine hydrochloride 92-A (160 mg, 0.68 mmol) and triethyl amine (207 mg, 2.04 mmol) in 10 mL of CH2CI2 at room temperature was added acid chloride 1-B (170 mg, 0.88 mmol). Reaction was continued for 2h, and the mixture was concentrated. The residue was purified by preparative TLC to provide amide intermediate 92-B as a colorless solid (150 mg, 62%). 1H NMR (400 MHz, CDC13) delta: .35-126 (m, 3H), 7.21 (d, J = 8.4 Hz, 2H), 7.04 (t, J = 8.4 Hz, 1H), 5.88 (br, 1H), 4.61 (d, J = 5.6 Hz, 2H), 2.37 (s, 3H). LC-MS: m/z = 356.0 [M+H]+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1171381-49-9.
Reference:
Patent; BIOGEN IDEC MA INC.; CHAO, Jianhua; ENYEDY, Istvan, J.; GUERTIN, Kevin; HUTCHINGS, Richard, H.; JONES, John, Howard; POWELL, Noel; VANVLOTEN, Kurt, D.; WO2014/8214; (2014); A1;,
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