Category: 1159977-65-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1159977-65-7 as follows. COA of Formula: C6H4BrN3

To a mixture of 2,4-difluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide (2.13 g, 5.0 mmol), 6-bromoimidazo[1,2-b]pyridazine (1 g, 0.79 mmol), Pd(dppf)Cl2.CH2Cl2 (408 mg, 0.5 mmol) and Na2CO3 (1.32 g, 12.5 mmol) were added DME (120 mL) and water (30 mL). The mixture was stirred at 70 C. under N2 atmosphere for 4 hours, then cooled to rt, quenched with H2O (500 mL), and then extracted with EtOAc (500 mL*3). The combined organic phases were concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/MeOH (v/v)=200/3) to give the title compound as a light brown solid (1.28 g, 61.4%). MS (ESI, pos. ion) m/z: 418.0 [M+H]+.

According to the analysis of related databases, 1159977-65-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Calitor Sciences, LLC; Xi, Ning; US2014/134133; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1159977-65-7, name is 6-Bromoimidazo[1,2-b]pyridazine, A new synthetic method of this compound is introduced below., Formula: C6H4BrN3

To degassed dioxane (10ml_) were added sequentially 2-aminopyrazine (1) (54mg, 0.57mmol), 6-bromoimidazo[1 ,2-b]pyridazine (2) (136mg, 0.69mmol), Pd2(dba)3 (26mg, 0.03mmol), XantPhos (33mg, 0.06mmol) and Cs2C03 (371 mg, 1.1 mmol) with continued degassing. The reaction mixture was heated up to 90C for 2h. Once cooled down to rt, it was poured into a brine solution (50%, 20ml_) and extracted with EtOAc (3 x 20ml_). The combined organic extracts were dried over MgS04, filtered and concentrated in vacuo. Purification by silica gel column chromatography with EtOAc/MeOH (1 :0-0: 1 ) afforded a residue. It was re- dissolved in CH2CI2/MeOH (4:1 , 20ml_) and swirled with MP-TMT resin (250mg, 1.3mmol/g) at rt overnight. The solution was filtered, the resin washed with CH2CI2/MeOH (4:1 , 50ml_) and the filtrate concentrated in vacuo to yield (3) as an off-white solid (94mg, 77%). (0916) LCMS (ES): Found 213.0 [M+Hf. (0917) 1H NMR (300 MHz, DMSO-cf6), d: 10.40 (s, 1 H), 9.39 (d, J=1.3 Hz, 1 H), 8.32- 8.40 (m, 1 H), 8.26 (d, J=2.4 Hz, 1 H), 8.20 (s, 1 H), 8.04 (d, J= 9.6 Hz, 1 H), 7.66 (d, J= 0.6 Hz, 1 H), 7.35 (d, J= 9.6 Hz, 1 H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; KARUS THERAPEUTICS LIMITED; SHUTTLEWORTH, Stephen Joseph; GATLAND, Alice Elizabeth; FINNEMORE, Daniel John; ALEXANDER, Rikki Peter; SILVA, Franck; CECIL, Alexander; (233 pag.)WO2019/166824; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 1159977-65-7, name is 6-Bromoimidazo[1,2-b]pyridazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1159977-65-7

To a solution of 6-bromoimidazo[1,2-b]pyridazine (1.98 g, 10.0 mmol) in methanol (50 mL) at -10 C. was added N-iodosuccinimide (2.47 g, 11.0 mmol) in portions. The mixture was stirred at -10 C. for 30 minutes and then allowed to warm up to rt. The reaction was continued to stir at rt for 18 hours, and then concentrated in vacuo. The residue was dissolved in 100 mL of DCM and washed with 50 mL of aqueous Na2CO3 solution. The organic phase was concentrated in vacuo to give the title compound as a light yellow solid (2.0 g, 61%). MS (ESI, pos. ion) m/z: 323.9 [M+H]+; 1H NMR (400 MHz, CDCl3): delta 7.83 (s, 1H), 7.78 (d, J=9.4 Hz, 1H), 7.21 (d, J=9.4 Hz, 1H).

The synthetic route of 6-Bromoimidazo[1,2-b]pyridazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Calitor Sciences, LLC; Xi, Ning; US2014/134133; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1159977-65-7, name is 6-Bromoimidazo[1,2-b]pyridazine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H4BrN3

To a solution of intermediate 26B (100 mg, 0.246 mmol) in 1,4-dioxane (3 mL) was added BisPin (94 mg, 0.3 70 mmol) and potassium acetate (72.6 mg, 0.73 9 mmol). The solution was purged with argon for 2 mm. and PdC12(dppf)-CH2C12 adduct (10.06mg, 0.0 12 mmol) was added. The reaction mixture was heated at 90 C for 3 h and cooled to RT. 6-Bromoimidazo[1,2-bjpyridazine (48.8 mg, 0.246 mmol), aqueous 3M K3P04 solution (0.370 mL, 0.739 mmol) and PdC12(dppf)-CH2C12 adduct (10.06 mg, 0.012 mmol) were added. The reaction mixture was heated at 90 C for 16 h, cooled to RT and concentrated in vacuo. The crude product was purified by silica gelchromatography (12 g RediSep column, eluting with a gradient of 40-100 % EtOAc in petroleum ether). Fractions containing the desired product were combined and evaporated under reduced pressure to afford intermediate 26B (30 mg, 27.4 % yield). MS (ES): m/z = 444.5 [M+Hj HPLC Ret. Time 1.25 mm. (HPLC Methods B).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1159977-65-7.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; LIU, Peiying; TEBBEN, Andrew J.; VELAPARTHI, Upender; RAHAMAN, Hasibur; TONUKUNURU, Gopikishan; WARRIER, Jayakumar Sankara; (264 pag.)WO2018/17633; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary