Category: 113899-55-1

Synthetic Route of 113899-55-1, These common heterocyclic compound, 113899-55-1, name is 1-(2-Bromophenyl)ethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add diisopropylethylamine (1.5 g, 12 mmol) to a solution of l-(2-bromo-4- fluoro-phenyl)-ethylamine (4 g, 20 mmol) and di-tert-butyldicarbonate (6.5 g, 30 mmol) in 20 mL of DCM. Stir the mixture overnight at RT. Dilute the mixture with chloroform/IPA (3/1), wash with aqueous saturated sodium chloride and water, dry it over sodium sulfate and concentrate in vacuo. Purify the crude product by column chromatography (10 % methanol in DCM) to give the title compound (2.0 g, 33 %). MS (ES) m/z 244/246 [M-tert-butyl]+.

Statistics shows that 1-(2-Bromophenyl)ethylamine is playing an increasingly important role. we look forward to future research findings about 113899-55-1.

Reference:
Patent; ELI LILLY AND COMPANY; WO2008/144223; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 113899-55-1, A common heterocyclic compound, 113899-55-1, name is 1-(2-Bromophenyl)ethylamine, molecular formula is C8H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) Di-t-butyl dicarbonate (1.26 ml) was added to a solution of 1-(2-bromophenyl)ethanamine (1.0 g) obtained by the method described in the literature (Tetrahedron Letters, 2007, vol. 48, p.4589) in chloroform (10 ml), and the resulting mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (chloroform:methanol = 50:1) to obtain a protected compound (1.52 g).

The synthetic route of 113899-55-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; Meiji Seika Kaisha, Ltd.; EP2287173; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary