Category: 1129-28-8

In 2018,Ramsbeck, Daniel; Hamann, Antje; Richter, Georg; Schlenzig, Dagmar; Geissler, Stefanie; Nykiel, Vera; Cynis, Holger; Schilling, Stephan; Buchholz, Mirko published 《Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors》.Journal of Medicinal Chemistry published the findings.Recommanded Product: Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:

The metalloproteinase meprin β emerged as a current drug target for the treatment of a number of disorders, among those fibrosis, inflammatory bowel disease and Morbus Alzheimer. A major obstacle in the development of metalloprotease inhibitors is target selectivity to avoid side effects by blocking related enzymes with physiol. functions. Here, we describe the structure-guided design of a novel series of compounds, based on previously reported highly active meprin β inhibitors. The bioisosteric replacement of the sulfonamide scaffold gave rise to a next generation of meprin inhibitors. Selected compounds based on this novel amine scaffold exhibit high activity against meprin β and also remarkable selectivity over related metalloproteases, i.e., matrix metalloproteases and A disintegrin and metalloproteinases. In the experiment, the researchers used many compounds, for example, Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Recommanded Product: Methyl 3-(bromomethyl)benzoate Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Nikodemiak, Paul; Koert, Ulrich published 《Metal-Catalyzed Synthesis of Functionalized 1,2,4-Oxadiazoles from Silyl Nitronates and Nitriles》.Advanced Synthesis & Catalysis published the findings.Electric Literature of C9H9BrO2 The information in the text is summarized as follows:

The metal-catalyzed cycloaddition of silyl nitronates and nitriles leading to 1,2,4-oxadiazoles I [R = Me, 1-cyclohexene, Ph, etc.; R1 = Me, CH2Cl, CO2Me, etc.] was described. Silver(I) triflate (AgOTf) and ytterbium(III) triflate [Yb(OTf)3] were the suitable catalysts. A variety of functional groups was tolerated in the nitrile. The reaction worked well for alkenyl and aryl silyl nitronates while the use of alkyl silyl nitronates was less efficient. Mechanistic studies were in favor of an elimination of tert-butyl(dimethyl)silanol (TBSOH) after the cycloaddition step. This new approach was also applied for the synthesis of the drug ataluren. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Electric Literature of C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Electric Literature of C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Joergensen, Lars; Al-Khawaja, Anas; Kickinger, Stefanie; Vogensen, Stine B.; Skovgaard-Petersen, Jonas; Rosenthal, Emil; Borkar, Nrupa; Loffler, Rebekka; Madsen, Karsten K.; Brauner-Osborne, Hans; Schousboe, Arne; Ecker, Gerhard F.; Wellendorph, Petrine; Clausen, Rasmus P. published 《Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1)》.Journal of Medicinal Chemistry published the findings.Application of 1129-28-8 The information in the text is summarized as follows:

N-(1-Benzyl-4-piperidinyl)-2,4-dichlorobenzamide (BPDBA) is a noncompetitive inhibitor of the betaine/GABA transporter 1 (BGT1). The authors here report the synthesis and structure-activity relationship of 71 analogs. The authors identify I as a more soluble 2,4-Cl substituted 3-pyridine analog with retained BGT1 activity and an improved off-target profile compared to BPDBA. The authors performed radioligand-based uptake studies at chimeric constructs between BGT1 and GAT3, experiments with site-directed mutated transporters, and computational docking in a BGT1 homol. model based on the newly determined x-ray crystal structure of the human serotonin transporter (hSERT). On the basis of these experiments, the authors propose a binding mode involving residues within TM10 in an allosteric site in BGT1 that corresponds to the allosteric binding pocket revealed by the hSERT crystal structure. The study provides first insights into a proposed allosteric binding pocket in BGT1, which accommodates the binding site for a series of novel noncompetitive inhibitors. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Application of 1129-28-8 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wong, Iris L. K.; Zhu, Xuezhen; Chan, Kin-Fai; Liu, Zhen; Chan, Chin-Fung; Chow, Tsun Sing; Chong, Tsz Cheung; Law, Man Chun; Cui, Jiahua; Chow, Larry M. C.; Chan, Tak Hang published an article in 2021. The article was titled 《Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2)》, and you may find the article in Journal of Medicinal Chemistry.Synthetic Route of C9H9BrO2 The information in the text is summarized as follows:

We synthesize various substituted triazole-containing flavonoids and identify potent, nontoxic, and highly selective BCRP inhibitors. Ac18Az8 (I), Ac32Az19 (II), and Ac36Az9 (III) possess m-methoxycarbonylbenzyloxy substitution at C-3 of the flavone moiety and substituted triazole at C-4′ of the B-ring. They show low toxicity (IC50 toward L929 > 100μM), potent BCRP-inhibitory activity (EC50 = 1-15 nM), and high BCRP selectivity (BCRP selectivity over MRP1 and P-gp > 67-714). They inhibit the efflux activity of BCRP, elevate the intracellular drug accumulation, and restore the drug sensitivity of BCRP-overexpressing cells. Like Ko143, Ac32Az19 remarkably exhibits a 100% 5D3 shift, indicating that it can bind and cause a conformational change of BCRP. Moreover, it significantly reduces the abundance of functional BCRP dimers/oligomers by half to retain more mitoxantrone in the BCRP-overexpressing cell line and that may account for its inhibitory activity. They are promising candidates to be developed into combination therapy to overcome MDR cancers with BCRP overexpression. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Synthetic Route of C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Synthetic Route of C9H9BrO2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Li, Yue; Ouyang, Yifan; Wu, Han; Wang, Peng; Huang, Yu; Li, Xue; Chen, Hongtong; Sun, Yu; Hu, Xinxin; Wang, Xiukun; Li, Guoqing; Lu, Yun; Li, Congran; Lu, Xi; Pang, Jing; Nie, Tongying; Sang, Xiaohong; Dong, Luyao; Dong, Wenting; Jiang, Jiandong; Paterson, Ian C.; Yang, Xinyi; Hong, Wei; Wang, Hao; You, Xuefu published an article in European Journal of Medicinal Chemistry. The title of the article was 《The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates》.Application of 1129-28-8 The author mentioned the following in the article:

The shortage of new antibiotics makes infections caused by gram-neg. (G-) bacteria a significant clin. problem. The key enzymes involved in folate biosynthesis represent important targets for drug discovery, and new antifolates with novel mechanisms are urgently needed. By targeting to dihydrofolate reductase (DHFR), a series of 1,3-diamino-7H-pyrrol[3,2-f]quinazoline (PQZ) compounds were designed, and exhibited potent antibacterial activities in vitro, especially against multi-drug resistant G- strains. Multiple experiments indicated that PQZ compounds contain a different mol. mechanism against the typical DHFR inhibitor, trimethoprim (TMP), and the thymidylate synthase (TS) was identified as another potential but a relatively weak target. A significant synergism between the representative compound, OYYF-175, and sulfamethoxazole (SMZ) was observed with a strong cumulative and significantly bactericidal effect at extremely low concentrations (2 μg/mL for SMZ and 0.03 pg/mL for OYYF-175), which could be resulted from the simultaneous inhibition of dihydropteroate synthase (DHPS), DHFR and TS. PQZ compounds exhibited therapeutic effects in a mouse model of i.p. infections caused by Escherichia coli (E. coli). The co-crystal structure of OYYF-175-DHFR was solved and the detailed interactions were provided. The inhibitors reported represent innovative chem. structures with novel mol. mechanism of action, which will benefit the generation of new, efficacious bactericidal compounds In addition to this study using Methyl 3-(bromomethyl)benzoate, there are many other studies that have used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application of 1129-28-8) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Application of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Legarda, Pablo D.; Garcia-Rubia, Alfonso; Gomez Arrayas, Ramon; Carretero, Juan C. published 《Palladium-Catalyzed Remote ortho-C-H Alkenylation of Alkyl Aryl Sulfones: Access to Densely Functionalized Indane Derivatives》.Advanced Synthesis & Catalysis published the findings.Safety of Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:

A practical method for the palladium-catalyzed ortho-olefination of benzyl and phenethyl 2-pyridyl sulfones with electron-deficient alkenes using N-fluoro-2,4,6-trimethylpyridinium triflate ([F+]) as the terminal oxidant is described. The chelating auxiliary (2-pyridyl)sulfonyl unit was demonstrated to be the key to the success of this reaction, which occurs efficiently with excellent regioselectivity and monosubstitution selectivity. A variety of steric and electronic changes to both coupling partners is tolerated, including substitution at the benzylic position of the sulfone compound Furthermore, no appreciable loss of enantiopurity is observed when using non-racemic substrates. This method provides access to indane derivatives holding three contiguous stereogenic centers with high diastereocontrol. The indane framework was constructed by intramol. Michael addition of the α-sulfonyl carbanion to the electrophilic alkene. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Safety of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Safety of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C9H9BrO2In 2016 ,《Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors》 appeared in Organic & Biomolecular Chemistry. The author of the article were De Vreese, Rob; Depetter, Yves; Verhaeghe, Tom; Desmet, Tom; Benoy, Veronick; Haeck, Wanda; Van Den Bosch, Ludo; D’hooghe, Matthias. The article conveys some information:

The synthesis of novel isoform-selective HDAC inhibitors is considered to be an important, emerging field in medicinal chem. In this paper, the preparation and assessment of thirteen selective HDAC6 inhibitors is disclosed, elaborating on a previously developed thiaheterocyclic Tubathian series. All compounds were evaluated in vitro for their ability to inhibit HDAC6, and a selection of five potent compounds was further screened toward all HDAC isoforms (HDAC1-11). The capability of these Tubathian analogs to inhibit α-tubulin deacetylation was assessed as well, and ADME/Tox data were collected. This thorough SAR evaluation revealed that the oxidized, para-substituted hydroxamic acids can be recognized as valuable lead structures in the pursuit of novel potent and selective HDAC6 inhibitors. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Electric Literature of C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Electric Literature of C9H9BrO2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of Methyl 3-(bromomethyl)benzoateIn 2017 ,《Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation》 was published in Journal of Medicinal Chemistry. The article was written by Smith, Thomas P.; Windsor, Ian W.; Forest, Katrina T.; Raines, Ronald T.. The article contains the following contents:

Transthyretin (TTR) is a homotetrameric protein. Its dissociation into monomers leads to the formation of fibrils that underlie human amyloidogenic diseases. The binding of small mols. to the thyroxin-binding sites in TTR stabilizes the homotetramer and attenuates TTR amyloidosis. Herein, we report on boronic acid-substituted stilbenes that limit TTR amyloidosis in vitro. Assays of affinity for TTR and inhibition of its tendency to form fibrils were coupled with X-ray crystallog. anal. of nine TTR·ligand complexes. The ensuing structure-function data led to a sym. diboronic acid that forms a boronic ester reversibly with serine 117. This diboronic acid inhibits fibril formation by both wild-type TTR and a common disease-related variant, V30M TTR, as effectively as does tafamidis, a small-mol. drug used to treat TTR-related amyloidosis in the clinic. These findings establish a new modality for covalent inhibition of fibril formation and illuminate a path for future optimization. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Quality Control of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of Methyl 3-(bromomethyl)benzoate Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase》 was written by Shaw, Scott A.; Vokits, Benjamin P.; Dilger, Andrew K.; Viet, Andrew; Clark, Charles G.; Abell, Lynn M.; Locke, Gregory A.; Duke, Gerald; Kopcho, Lisa M.; Dongre, Ashok; Gao, Ji; Krishnakumar, Arathi; Jusuf, Sutjano; Khan, Javed; Spronk, Steven A.; Basso, Michael D.; Zhao, Lei; Cantor, Glenn H.; Onorato, Joelle M.; Wexler, Ruth R.; Duclos, Franck; Kick, Ellen K.. Synthetic Route of C9H9BrO2This research focused ontriazolopyridine preparation myeloperoxidase inhibitor; structure arylmethyl aminophenylpropyl triazolopyridine inhibition myeloperoxidase selectivity; Atherosclerosis; Myeloperoxidase; Triazolopyridine. The article conveys some information:

Myeloperoxidase (MPO) is a heme peroxidase found in neutrophils, monocytes and macrophages that efficiently catalyzes the oxidation of endogenous chloride into hypochlorous acid for antimicrobial activity. Chronic MPO activation can lead to indiscriminate protein modification causing tissue damage, and has been associated with chronic inflammatory diseases, atherosclerosis, and acute cardiovascular events. A previously-known benzyloxy triazolopyrimidine was a reversible MPO inhibitor; however it suffered from poor stability in acid, and is an irreversible inhibitor of the DNA repair protein Me guanine Me transferase (MGMT). Structure-based drug design was employed to discover benzyl triazolopyridines such as I with improved MPO potency, as well as acid stability, no reactivity with MGMT, and selectivity against thyroid peroxidase (TPO). Structure-activity relationships, a crystal structure of the MPO-inhibitor complex, and acute in vivo pharmacodynamic data are described herein. In addition to this study using Methyl 3-(bromomethyl)benzoate, there are many other studies that have used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Synthetic Route of C9H9BrO2) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Synthetic Route of C9H9BrO2 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Gaisina, Irina N.; Peet, Norton P.; Wong, Letitia; Schafer, Adam M.; Cheng, Han; Anantpadma, Manu; Davey, Robert A.; Thatcher, Gregory R. J.; Rong, Lijun. Category: bromides-buliding-blocks The article mentions the following:

The recent Ebola epidemics in West Africa underscore the great need for effective and practical therapies for future Ebola virus outbreaks. We have discovered a new series of remarkably potent small mol. inhibitors of Ebola virus entry. These 4-(aminomethyl)benzamide-based inhibitors are also effective against Marburg virus. Synthetic routes to these compounds allowed for the preparation of a wide variety of structures, including a conformationally restrained subset of indolines (compounds 41-50). Compounds 20, 23, 32, 33, and 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses. Representative compounds (20, 32, and 35) have shown good metabolic stability in plasma and liver microsomes (rat and human), and 32 did not inhibit CYP3A4 nor CYP2C9. These 4-(aminomethyl)benzamides are suitable for further optimization as inhibitors of filovirus entry, with the potential to be developed as therapeutic agents for the treatment and control of Ebola virus infections. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Category: bromides-buliding-blocks)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary