Category: 1129-28-8

Yan, Si-Shun; Liu, Shi-Han; Chen, Lin; Bo, Zhi-Yu; Jing, Ke; Gao, Tian-Yu; Yu, Bo; Lan, Yu; Luo, Shu-Ping; Yu, Da-Gang published an article in 2021. The article was titled 《Visible-light photoredox-catalyzed selective carboxylation of C(sp3)-F bonds with CO2》, and you may find the article in Chem.Category: bromides-buliding-blocks The information in the text is summarized as follows:

A novel selective carboxylation of C(sp3)-F bonds with CO2 via visible-light photoredox catalysis. A variety of mono-, di-, and trifluoroalkylarenes as well as α,α-difluorocarboxylic esters and amides undergo such reactions to give important aryl acetic acids and α-fluorocarboxylic acids, including several drugs and analogs, under mild conditions. Notably, mechanistic studies and DFT calculations demonstrate the dual role of CO2 as an electron carrier and electrophile during this transformation. The fluorinated substrates would undergo single-electron reduction by electron-rich CO2 radical anions, which were generated in situ from CO2 via sequential hydride-transfer reduction and hydrogen-atom-transfer processes. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Category: bromides-buliding-blocks)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: Methyl 3-(bromomethyl)benzoateIn 2016 ,《Design, synthesis and biological evaluation of stilbene derivatives as novel inhibitors of protein Tyrosine Phosphatase 1B》 was published in Molecules. The article was written by He, Haibing; Ge, Yinghua; Dai, Hong; Cui, Song; Ye, Fei; Jin, Jia; Shi, Yujun. The article contains the following contents:

By imitating the scaffold of lithocholic acid (LCA), a natural steroidal compound displaying Protein Tyrosine Phosphatase 1B (PTP1B) inhibitory activity, a series of stilbene derivatives containing phenyl-substituted isoxazoles were designed and synthesized. The structures of the title compounds were confirmed by 1H-NMR, 13C-NMR and HRMS. Activities of the title compounds were evaluated on PTP1B and the homologous enzyme TCPTP by using a colorimetric assay. Most of the target compounds had good activities against PTP1B. Among them, compound 29 (IC50 = 0.91 ± 0.33 μM), characterized by a 5-(2,3-dichlorophenyl) isoxazole moiety, exhibited an activity about 14-fold higher than the lead compound LCA and a 4.2-fold selectivity over TCPTP. Compound 29 was identified as a competitive inhibitor of PTP1B with a Ki value of 0.78 μM in enzyme kinetic studies. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Recommanded Product: Methyl 3-(bromomethyl)benzoate The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Lewis acid-assisted Ir(III) reductive elimination enables construction of seven-membered-ring sulfoxides》 was published in Chemical Science in 2020. These research results belong to Yang, Wu; Li, Yingzi; Zhu, Jiefeng; Liu, Wentan; Ke, Jie; He, Chuan. Related Products of 1129-28-8 The article mentions the following:

Iridium has played an important role in the evolution of C-H activation chem. over the last half century owing to its high reactivity towards stoichiometric C-H bond cleavage; however, the use of Ir(III) complexes in catalytic C-H functionalization/C-C bond formation appears to have fallen off significantly. The main problem lies in the reductive elimination step, as iridium has a tendency to form stable and catalytically inactive Ir(III) species. Herein, with a rationally designed Lewis acid assisted oxidatively induced strategy, the sluggish Ir(III) reductive elimination is successfully facilitated, enabling the facile C-C bond formation. The X-ray crystal structure of a silver salt adduct of iridacycle and DFT calculations demonstrate that the sulfoxide group acts as a key bridge connecting the Ir(III) metal center with the silver Lewis acid, which facilitates the reductive elimination of the Ir(III) metallacycle. Further identification of oxidants was carried out by performing stoichiometric reactions, which enables the development of catalytic construction of various highly functionalized seven-membered-ring sulfoxides e.g., 5,7-dihydrodibenzo[c,e]thiepine 6-oxide, that are of great interest in medicinal chem. and materials science. In the experiment, the researchers used many compounds, for example, Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Related Products of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Efficient Synthesis of Hydroxy-Substituted 2-Aminobenzo[d]thiazole-6-carboxylic Acid Derivatives as New Building Blocks in Drug Discovery》 was written by Durcik, Martina; Toplak, Zan; Zidar, Nace; Ilas, Janez; Zega, Anamarija; Kikelj, Danijel; Masic, Lucija Peterlin; Tomasic, Tihomir. Application In Synthesis of Methyl 3-(bromomethyl)benzoate And the article was included in ACS Omega in 2020. The article conveys some information:

Benzo[d]thiazole is widely used in synthetic and medicinal chem., and it is a component of many compounds and drugs that have several different bioactivities. Herein, an elegant pathway for synthesis of Me 4- and 5-hydroxy-2-amino-benzo[d]thiazole-6-carboxylates as building blocks that can be substituted at four different positions on the bicycle has been described and thus offer the possibility to thoroughly explore the chem. space around the mol. studied as a ligand for the chosen target. A series of 12 new compounds was prepared using the described methods and Williamson ether synthesis.Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application In Synthesis of Methyl 3-(bromomethyl)benzoate) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Application In Synthesis of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Photocatalytic α-Alkylation of Amines with Alkyl Halides》 was published in ACS Catalysis in 2020. These research results belong to Leng, Lingying; Ready, Joseph M.. Application of 1129-28-8 The article mentions the following:

α-Branched amines represent essential building blocks for organic synthesis. They are traditionally prepared through nucleophilic addition to imines. These methods often require highly reactive organometallic reagents and proceed under rigorous air- and moisture-free conditions. Here, an alternative approach that involves a C-alkylation of amines with alkyl bromides is described. Mechanistically, the reaction likely involves photocatalytic generation of an α-amino radical and a stabilized carbon-centered radical (allyl, benzyl, α-carbonyl) followed by radical recombination. This approach offers a mild, atom-economical, redox neutral synthesis of α-branched amines that shows broad scope and avoids premetalated reagents. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Application of 1129-28-8 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tojo, Toshifumi; Kubo, Yuhei; Kondo, Takeshi; Yuasa, Makoto published their research in Heterocycles in 2021. The article was titled 《Inverted positioning of DNMT1 inhibitor in the active site of DNMT1 caused by hydrophobicity/hydrophilicity of the terminal structure》.Quality Control of Methyl 3-(bromomethyl)benzoate The article contains the following contents:

DNA (cytosine-5)-methyltransferase 1 (DNMT1) is one of the enzymes that regulate DNA modification. It has been demonstrated that overexpression of DNMT1 is associated with the development of cancer, making DNMT1 an attractive mol. target for cancer therapy. Focused on the terminal structures of existing DNMT1 inhibitors, we designed and screened test compounds that possessed another functional group. Binding simulations identified compounds with a trifluoromethylphenyl group to insert in an inverted position against DNMT1 compared to existing DNMT1 inhibitors. These results suggest that the binding form against DNMT1 may depend on the hydrophobicity/hydrophilicity of the inhibitor′s terminal structure. In the experiment, the researchers used many compounds, for example, Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Quality Control of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Quality Control of Methyl 3-(bromomethyl)benzoate In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of Methyl 3-(bromomethyl)benzoateIn 2022 ,《Cobalt-Catalyzed 1,1,3-Triborylation of Terminal Alkynes》 was published in Organometallics. The article was written by Yang, Xiaoxu; Ge, Shaozhong. The article contains the following contents:

The authors have developed a Co-catalyzed regioselective 1,1,3-triborylation reaction of terminal alkynes with pinacolborane (HBpin) with a catalyst generated in situ from readily available and bench-stable Co(acac)2 and xantphos. A variety of terminal alkynes undergo this triborylation reaction, affording the corresponding 1,1,3-triborylalkanes in good yields with high selectivity. The synthetic utility of this catalytic protocol was demonstrated by developing selective stepwise functionalization of 1,1,3-triborylalkane products. The results of mechanistic studies, such as conducting control experiments and D-labeling reactions, monitoring the reaction process, and identifying reaction intermediates, suggest that this 1,1,3-triborylation reaction proceeds through 1,3-diborylation of alken-1-ylboronates formed by Co-catalyzed hydroboration of terminal alkynes. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application In Synthesis of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Application In Synthesis of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast》 was written by Schierle, Simone; Helmstaedter, Moritz; Schmidt, Jurema; Hartmann, Markus; Horz, Maximiliane; Kaiser, Astrid; Weizel, Lilia; Heitel, Pascal; Proschak, Anna; Hernandez-Olmos, Victor; Proschak, Ewgenij; Merk, Daniel. Quality Control of Methyl 3-(bromomethyl)benzoateThis research focused onZafirlukast derivative preparation farnesoid receptor epoxide hydrolase modulator steatohepatitis; NAFLD; NASH; Polypharmacology; non-alcoholic steatohepatitis; nuclear receptor. The article conveys some information:

The nuclear farnesoid X receptor (FXR) and the enzyme soluble epoxide hydrolase (sEH) are validated mol. targets to treat metabolic disorders such as non-alc. steatohepatitis (NASH). Their simultaneous modulation in vivo has demonstrated a triad of anti-NASH effects and thus may generate synergistic efficacy. Here we report dual FXR activators/sEH inhibitors derived from the anti-asthma drug Zafirlukast. Systematic structural optimization of the scaffold has produced favorable dual potency on FXR and sEH while depleting the original cysteinyl leukotriene receptor antagonism of the lead drug. The resulting polypharmacol. activity profile holds promise in the treatment of liver-related metabolic diseases. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Quality Control of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. Quality Control of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Agrawal, Neetesh; Machhi, Jatin; Rathwa, Virendra; Kanhed, Ashish M.; Patel, Sagar; Murumkar, Prashant; Gandhi, Hardik; Yadav, Mange Ram published 《Exploration of 6,7-dimethoxyquinazoline derivatives as dual acting α1- and AT1-receptor antagonists: synthesis, evaluation, pharmacophore & 3D-QSAR modeling and receptor docking studies》.RSC Advances published the findings.SDS of cas: 1129-28-8 The information in the text is summarized as follows:

The 6,7-dimethoxyquinazoline scaffold was further explored to provide dual acting α1- and AT1-receptor antagonists by synthesizing a series of derivatives and biol. evaluating the newly synthesized compounds Based on the biol. data of the current compounds and the earlier reported compounds, pharmacophore models were developed for α1- and AT1-receptor antagonist activities. Subsequently, 3D-QSAR models were also derived for antagonism for both the receptors. The developed 3D-QSAR models were validated using various statistical parameters and both the developed models were further validated using terazosin and prazosin as external compounds Docking studies confirmed receptor-ligand stabilizing interactions of the balanced-dual active antagonist (110) in the active sites of both α1- as well as AT1-receptors, the structures of which were obtained by homol. modeling. Two (42 and 110) of the compounds from the newly synthesized derivatives offered the highest potency (pA2 for α1 = 9.45 and 8.77 and AT1 = 8.36 and 8.60 resp.) with balanced modulation of both the receptors. Both the compounds were found to be slightly less potent to terazosin as α1-antagonists and equipotent to losartan as AT1-antagonists in the in vivo animal model. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8SDS of cas: 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. SDS of cas: 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of Benzyl 2-Deoxy-C-Glycosides》 was published in ACS Omega in 2020. These research results belong to Shinozuka, Tsuyoshi. Application of 1129-28-8 The article mentions the following:

A synthetic method for benzyl 2-deoxy-C-glycosides has been developed. Palladium-catalyzed benzyl C-glycosylation of TIPS-protected 1-tributylstannyl glycals with a variety of benzyl bromides provided protected benzyl C-glycals. In this reaction, the use of PdCl2(dppe) promoted a clean reaction, whereas the reaction was accelerated by the addition of Na2CO3. The subsequent transformations provided a novel class of benzyl 2-deoxy-C-glycosides. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary