In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 112342-72-0 as follows. Product Details of 112342-72-0
Reference Example 444 6-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)[1,3]thiazolo[4,5-b]pyrazine A mixture of 2-amino-6-bromo[1,3]thiazolo[4,5-b]pyrazine (8.00 g) synthesized by the method described in , n-hexane-2,5-dione (8.10 mL) and p-toluenesulfonic acid monohydrate (658 mg) in toluene (86.0 mL) was heated under reflux overnight. Under ice-cooling, saturated aqueous sodium hydrogen carbonate solution was added and the mixture was extracted twice with chloroform. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated, and the obtained residue was purified by silica gel column chromatography (solvent; hexane/ethyl acetate=100/0 – 80/20) to give the title compound (8.33 g). MS(ESI)m/z; 309,311[M+H]+
According to the analysis of related databases, 112342-72-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; OKUYAMA, Masahiro; FUKUNAGA, Kenji; USUI, Kenji; HAYASHI, Norimitsu; IIJIMA, Daisuke; HORIUCHI, Hideki; FUJIMOTO, Nobuaki; (218 pag.)EP3372601; (2018); A1;,
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