Category: 112279-72-8

Electric Literature of 112279-72-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112279-72-8 name is 4-Bromo-2,3-difluoroaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

N-((4-bromo-2,3-difluorophenyl)carbamothioyl)benzamide was prepared according to the following procedure. To 4-bromo-2,3-difluoroaniline (3.70 g, 17.8 mmol) dissolved in acetone (20 mL) was added benzoyl isothiocyanate (2.90 g, 2.39 mL, 1 eq, 17.8 mmol) drop-wise. The reaction was stirred for 30 min at 18 C, the mixture was filtered, the collected white solid was washed with heptane (50 mL) and vacuum dried to afford N-((4-bromo-2,3-difluorophenyl)carbamothioyl)benzamide (5.68 g, 85%) as a white solid.?H NMR (300 MHz, DMSO-ifc) d 12.45 (s, 1H), 11.91 (s, 1H), 8.46 – 7.88 (m, 2H), 7.78 – 7.26 (m, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2,3-difluoroaniline, and friends who are interested can also refer to it.

Reference:
Patent; ACUCELA INC.; ORME, Mark, W.; ZUNIGA, Edison, S.; KUKSA, Vladimir, A.; CRAFT, Russell, Stuart; SAVEEDRA, Eduardo, Moreno; MEISSNER, Johannes, Wilhelm, Georg; DEN HARTOG, Jacobus, Antonius, Joseph; DROS, Albert, Cornelis; (223 pag.)WO2020/69330; (2020); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 112279-72-8, name is 4-Bromo-2,3-difluoroaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 112279-72-8

Benzyl chloroformate (1.1 mL, 7.5 mmol) was added dropwise with stirring to the Intermediate 52 (1.0 g, 4.8 mmol) in 10% aq. NaOH (15 mL)) and THF (30 mL) at ca. 0 C. The reaction mixture was stirred at r.t. for ca. 6 h. The reaction was quenched with 10% NH4Cl solution and extracted with DCM (2×50 mL). Combined organic layers were washed with brine, dried (Na2SO4), and concentrated under vacuum. The residue was purified by preparative TLC (10% ethyl acetate/petroleum ether) to give the product as a white solid. 1H NMR (400 MHz, CDCl3): 7.88 (m, 1H); 7.40 (m, 5H); 6.90 (m, 1H); 5.25 (s, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Gordeev, Mikhail Fedorovich; US2009/48305; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 112279-72-8,Some common heterocyclic compound, 112279-72-8, name is 4-Bromo-2,3-difluoroaniline, molecular formula is C6H4BrF2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of Compound (G-2) (78 g, 375 mmol) in anhydrous dichloromethane (250 mL) was added acetic anhydride (53.2 ml, 563 mmol) at room temperature, then the reaction mixture was stirred for 1 hour. After the completion of the reaction, the insoluble residue was collected by filtration to give Compound (G-3) (85.3 g, 91%).Compound (G-3);1H-NMR (DMSO-d6) delta: 2.10 (s, 3H), 7.48 (t, J=7.2 Hz, 1H), 7.72 (t, J=7.2 Hz, 1H), 10.32 (s, 1H).

The synthetic route of 112279-72-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shionogi & Co., Ltd.; US2012/253040; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 112279-72-8, name is 4-Bromo-2,3-difluoroaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112279-72-8, category: bromides-buliding-blocks

Step 1 : To a solution of 4-bromo-2,3-difluoroaniline (7.66 g, 36.8 mmol) in acetone (60 mL) was dropped under ice-cooling benzoyl isothiocyanate (9.02 g, 55.2 mmol). The mixture was stirred at rt for 18 h. The precipitate was collected by filtration and washed with hexane. The obtained product was dried under reduced pressure to give A/-((4-bromo-2,3- difluorophenyl)carbamothioyl)benzamide lnt-6a-2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; SCHMITT, Aaron C.; GEGE, Christian; (205 pag.)WO2016/96115; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 112279-72-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112279-72-8 name is 4-Bromo-2,3-difluoroaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

N-((4-bromo-2,3-difluorophenyl)carbamothioyl)benzamide was prepared according to the following procedure. To 4-bromo-2,3-difluoroaniline (3.70 g, 17.8 mmol) dissolved in acetone (20 mL) was added benzoyl isothiocyanate (2.90 g, 2.39 mL, 1 eq, 17.8 mmol) drop-wise. The reaction was stirred for 30 min at 18 C, the mixture was filtered, the collected white solid was washed with heptane (50 mL) and vacuum dried to afford N-((4-bromo-2,3-difluorophenyl)carbamothioyl)benzamide (5.68 g, 85%) as a white solid.?H NMR (300 MHz, DMSO-ifc) d 12.45 (s, 1H), 11.91 (s, 1H), 8.46 – 7.88 (m, 2H), 7.78 – 7.26 (m, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2,3-difluoroaniline, and friends who are interested can also refer to it.

Reference:
Patent; ACUCELA INC.; ORME, Mark, W.; ZUNIGA, Edison, S.; KUKSA, Vladimir, A.; CRAFT, Russell, Stuart; SAVEEDRA, Eduardo, Moreno; MEISSNER, Johannes, Wilhelm, Georg; DEN HARTOG, Jacobus, Antonius, Joseph; DROS, Albert, Cornelis; (223 pag.)WO2020/69330; (2020); A2;,
Bromide – Wikipedia,
bromide – Wiktionary