Category: 111865-47-5

Kitagawara, Yumina published the artcileNovel bioactivation pathway of benzbromarone mediated by cytochrome P450, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Drug Metabolism & Disposition (2015), 43(9), 1303-1306, database is CAplus and MEDLINE.

Benzbromarone (BBR) is a hepatotoxic drug, but the detailed mechanism of its toxicity remains unknown. We identified 2,6-dibromohydroquinone (DBH) and mono-debrominated catechol (2-ethyl-3-(3-bromo-4,5-dihydroxybenzoyl)benzofuran; CAT) as novel metabolites of BBR in rat and human liver microsomal systems by comparison with chem. synthesized authentic compounds, and we also elucidated that DBH is formed by cytochrome P 450 2C9 and that CAT is formed mainly by CYP1A1, 2D6, 2E1, and 3A4. Furthermore, CAT, DBH, and the oxidized form of DBH are highly cytotoxic in HepG2 compared with BBR. Taken together, our data demonstrate that DBH, a novel reactive metabolite, may be relevant to BBR-induced hepatotoxicity.

Drug Metabolism & Disposition published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sugita, Hajime published the artcileUnusual cyclic polymerization through Suzuki-Miyaura coupling of polyphenylene bearing diboronate at both ends with excess dibromophenylene, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(2), 396-399, database is CAplus and MEDLINE.

The Suzuki-Miyaura coupling polymerization of p-dibromophenylene and m-phenylenediboronic acid ester, as well as m-dibromophenylene and p-phenylenediboronic acid ester, and the combination of two meta-phenylene monomers in the presence of the t-Bu₃PPd(0) catalyst selectively afforded cyclic polyphenylenes with polyphenylene bearing boronate moieties at both ends when excess dibromophenylene was used.

Chemical Communications (Cambridge, United Kingdom) published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C5H11NO2S, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Martinez, Gabriel Espinosa published the artcileAccessing Pincer Bis(carbene) Ni(IV) Complexes from Ni(II) via Halogen and Halogen Surrogates, SDS of cas: 111865-47-5, the publication is Journal of the American Chemical Society (2016), 138(13), 4290-4293, database is CAplus and MEDLINE.

This communication describes the two-electron oxidation of (^DIPPCCC)NiX (^DIPPCCC = bis(diisopropylphenyl-benzimidazol-2-ylidene)phenyl; X = Cl or Br) with halogen and halogen surrogates to form (^DIPPCCC)NiX₃. These complexes represent a rare oxidation state of Ni, as well as an unprecedented reaction pathway to access these species through Br₂ and halogen surrogate (benzyltrimethylammonium tribromide). The Ni(IV) complexes were characterized by a suite of spectroscopic techniques and can readily reduce to the Ni(II) counterpart, allowing for cycling between the Ni(II)/Ni(IV) oxidation states.

Journal of the American Chemical Society published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, SDS of cas: 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ryden, Andreas published the artcileSynthesis and tentative identification of novel polybrominated diphenyl ether metabolites in human blood, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Chemosphere (2012), 88(10), 1227-1234, database is CAplus and MEDLINE.

Hydroxylated polybrominated di-Ph ethers (OH-PDBEs) are exogenous, bioactive compounds that originate, to a large extent, from anthropogenic activities, although they are also naturally produced in the environment. In the present study nine new authentic OH-PBDE reference standards and their corresponding Me ether derivatives (MeO-PBDEs) were synthesized and characterized by NMR spectroscopy and mass spectrometry. Seven of the authentic reference standards prepared were thereafter tentatively identified in a pooled human blood sample. The tentatively identified OH-PBDEs were 3-hydroxy-2,2′,4,4′,6-pentabromodiphenyl ether, 3′-hydroxy-2,2′,4,4′,6-pentabromodiphenyl ether, 3-hydroxy-2,2′,4,4′,5-pentabromodiphenyl ether, 3-hydroxy-2,2′,4,4′,5,6′-hexabromodiphenyl ether, 3′-hydroxy-2,2′,4,4′,5,6′-hexabromodiphenyl ether, 3-hydroxy-2,2′,4,4′,5,5′-hexabromodiphenyl ether and 4-hydroxy-2,2′,3,4′,5,5′,6-heptabromodiphenyl ether. An addnl. seven OH-PBDEs were tentatively identified in the pooled human blood sample, of which one OH-PBDE, 4′-hydroxy-2,2′,4,5,5′-pentabromodiphenyl ether, has not been identified in human blood before. The identification was performed using gas chromatog.-mass spectrometry (GC-MS) recording the bromine ions m/z 79, 81. The tentative identification was supported by the peaks relative retention times (RRTs) compared to authentic references on two GC columns of different polarities for the hexa-, and heptabrominated OH-PBDEs, and three different GC columns for the pentabrominated OH-PBDEs. The OH-PBDE congeners most likely originate from human metabolism of a flame retardant, i.e. polybrominated di-Ph ethers (PBDEs), due to the relatively high concentrations of PBDEs in the same human blood sample and the fact that these PBDEs could form the tentatively identified OH-PBDEs via metabolic direct hydroxylation or via 1,2-shift.

Chemosphere published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Miura, Yozo published the artcileNew Method for the Synthesis of N-tert-Alkoxyarylaminyl Radicals, Category: bromides-buliding-blocks, the publication is Journal of Organic Chemistry (2006), 71(13), 4786-4794, database is CAplus and MEDLINE.

The reactions of 2,4-diaryl-6-tert-butylnitrosobenzenes with 2,2′-azobis[2-(methoxycarbonyl)propane] (5a), 2,2′-azobis(2-cyano-4-methylpentane) (5b), and 2,2′-azobis(2-cyano-4-methyl-4-methoxypentane) (5c) in refluxing benzene gave stable N-tert-alkoxy-2,4-diaryl-6-tert-butylphenylaminyls, which were successfully isolated as radical crystals in 13-52% yields after column chromatog. The radical yields depended on the reaction time and the molar ratio of azo compounds to nitroso compounds In the same manner, acetyl- and cyano-group-carrying N-tert-alkoxyarylaminyls were generated by the reaction of 2-phenyl-4-(4-acetylphenyl)-6-tert-butylnitrosobenzene and 2-phenyl-4-(4-cyanophenyl)-6-tert-butylnitrosobenzene with 5a and 5b, and they were isolated as radical crystals. X-ray crystallog. analyses were performed for two radicals, and their mol. structures were discussed. The magnetic properties were measured for the two isolated radicals with SQUID in the temperature range 1.8-300 K. One radical showed a weak ferromagnetic interaction (θ = 0.2 K) between the radicals, and the other showed a weak antiferromagnetic interaction (θ = -3.8 K). The ferromagnetic interaction was analyzed based on the x-ray crystallog. structure.

Journal of Organic Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileOxidation using quaternary ammonium polyhalides. IV. Selective oxidation of sulfides to sulfoxides with benzyltrimethylammonium tribromide, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Bulletin of the Chemical Society of Japan (1989), 62(10), 3376-7, database is CAplus.

The reaction of sulfides with a stoichiometric amount of benzyltrimethylammonium tribromide and aqueous sodium hydroxide in dichloromethane at room temperature or in 1,2-dichloroethane under reflux gave the corresponding sulfoxides in good yields.

Bulletin of the Chemical Society of Japan published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileOxidation of thiols to disulfides with benzyltrimethylammonium tribromide, Quality Control of 111865-47-5, the publication is Chemistry Express (1991), 6(2), 129-32, database is CAplus.

Oxidation of RSH (R = Me₂CH, Me(CH₂)_n, n = 2-5, 7, PhCH₂, p-MeC₆H₄, p-ClC₆H₄, Ph, o-, p-tolyl, 2-benzothiazolyl) with benzyltrimethylammonium tribromide and NaOH in CH₂Cl₂-H₂O at room temperature gave 60-99% 13 RSSR.

Chemistry Express published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Quality Control of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileHalogenation using quaternary ammonium polyhalides. Part 22. Selective bromination of aromatic ethers with benzyltrimethylammonium tribromide, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1990), 897-9, database is CAplus.

The reaction of aromatic ethers with a stoichiometric amount of benzyltrimethylammonium tribromide in CH₂Cl₂-MeOH or HOAc-ZnCl₂ under mild conditions gave, selectively, mono-, di-, or tribromo aromatic ethers in quant. yield.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileOxidation using quaternary ammonium polyhalides. IX. Oxidation of hindered phenols with benzyltrimethylammonium tribromide, Category: bromides-buliding-blocks, the publication is Bulletin of the Chemical Society of Japan (1991), 64(3), 1060-2, database is CAplus.

Oxidation of hindered phenols, such as 2,6-di-tert-butyl-4-methylphenol, 3,5-di-tert-butyl-4-hydroxybenzyl alc., and 2,6-di-tert-butylphenol, with benzyltrimethylammonium tribromide were carried out in CH₂Cl₂ in the presence of water, tert-Bu alc., or aqueous NaOH at room temperature Sequential reaction processes were provided by the obtained products.

Bulletin of the Chemical Society of Japan published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileOxidation using quaternary ammonium polyhalides. VIII. Oxidation of 1,4-benzenediols with benzyltrimethylammonium tribromide, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Bulletin of the Chemical Society of Japan (1991), 64(1), 336-8, database is CAplus.

The reaction of 1,4-benzenediols with 1.1 equivalent of benzyltrimethylammonium tribromide in dichloromethane in the presence of aqueous sodium acetate at room temperature gave 2,5-cyclohexadiene-1,4-diones in good yields. On the other hand, the reaction of 1,4-benzenediols with a large excess of the reagent in aqueous acetic acid at 40-60° gave polybromo-substituted 2,5-cyclohexadiene-1,4-diones in good yields.

Bulletin of the Chemical Society of Japan published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary