Category: 111865-47-5

Asawapirom, Udom published the artcileDialkylcyclopentadithiophene polymers and copolymers, Application In Synthesis of 111865-47-5, the publication is Macromolecular Rapid Communications (2001), 22(10), 746-749, database is CAplus.

Poly(2,6-(4,4-dialkyl)-4H-cyclopenta[2,1-b:3,4-b’]dithiophene) (PCPDT) homopolymers and poly[(2,7-(9,9-dialkyl)fluorene)-co-(2,6-(4,4-dialkyl)-4H-cyclopenta[2,1-b:3,4-b’]dithiophene)] (PF/PCPDT) copolymers have been synthesized according to Yamamoto with Ni(COD)₂ (or NiCl₂/Zn in the case of the homopolymer). PCPDT is characterized by a red-shifted long wavelength absorption maximum (565 nm) when compared to that of polyfluorene (PF, 378 nm). In contrast to PF, its heteroaromatic analog PCPDT does not form thermotropic LC phases. The PF/PCPDT copolymers show clear indications for a block copolymer character (two separated π-π^* absorption maxima, two glass transitions).

Macromolecular Rapid Communications published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application In Synthesis of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ishi-i, Tsutomu published the artcileReaction of [2.2]Metacyclophanes Having an Internal C:C Bond with Brominating Agents, Product Details of C10H16Br3N, the publication is Journal of Organic Chemistry (1996), 61(15), 5103-5108, database is CAplus.

Treatment of (I) 5-tert-butyl-8-ethenyl[2.2]metacyclophane with benzyltrimethylammonium tribromide or bromine exclusively gave an addition-elimination product II. The bromination reactions of (E)-5-tert-butyl-8-(2-phenylethenyl)[2.2]metacyclophane and its (Z)-isomer were always stereoconvergent to give a mixture (40/60) of β-bromoolefins. On the other hand, when (E)-8,8′-(ethene-1,2-diyl)bis(5-tert-butyl[2.2]metacyclophane) and its (Z)-isomer were treated with the brominating agents, none of the products arising from the electrophilic attack of a bromonium ion on the central etheno bridge was obtained. The reaction of (E)-8,8′-(ethene-1,2-diyl)bis(5-tert-butyl[2.2]metacyclophane) gave a monotetrahydropyrene derivative and a bis-tetrahydropyrene derivative, products resulting from a transannular reaction-alkenyl migration sequence. The reaction pathway of the brominations mentioned above is discussed.

Journal of Organic Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Product Details of C10H16Br3N.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sankaranarayanan, Ananthakrishnan published the artcileNaphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure, Related Products of bromides-buliding-blocks, the publication is Molecular Pharmacology (2009), 75(2), 281-295, database is CAplus and MEDLINE.

Small-conductance (KCa2.1-2.3) and intermediate-conductance (KCa3.1) calcium-activated K⁺ channels are critically involved in modulating calcium-signaling cascades and membrane potential in both excitable and nonexcitable cells. Activators of these channels constitute useful pharmacol. tools and potential new drugs for the treatment of ataxia, epilepsy, and hypertension. Here, we used the neuroprotectant riluzole as a template for the design of KCa2/3 channel activators that are potent enough for in vivo studies. Of a library of 41 benzothiazoles, we identified 2 compounds, anthra[2,1-d]thiazol-2-ylamine (SKA-20) and naphtho[1,2-d]thiazol-2-ylamine (SKA-31), which are 10 to 20 times more potent than riluzole and activate KCa2.1 with EC₅₀ values of 430 nM and 2.9 μM, KCa2.2 with an EC₅₀ value of 1.9 μM, KCa2.3 with EC₅₀ values of 1.2 and 2.9 μM, and KCa3.1 with EC₅₀ values of 115 and 260 nM. Likewise, SKA-20 and SKA-31 activated native KCa2.3 and KCa3.1 channels in murine endothelial cells, and the more “drug-like” SKA-31 (half-life of 12 h) potentiated endothelium-derived hyperpolarizing factor-mediated dilations of carotid arteries from KCa3.1(+/+) mice but not from KCa3.1(-/-) mice. Administration of 10 and 30 mg/kg SKA-31 lowered mean arterial blood pressure by 4 and 6 mm Hg in normotensive mice and by 12 mm Hg in angiotensin-II-induced hypertension. These effects were absent in KCa3.1-deficient mice. In conclusion, with SKA-31, we have designed a new pharmacol. tool to define the functional role of the KCa2/3 channel activation in vivo. The blood pressure-lowering effect of SKA-31 suggests KCa3.1 channel activation as a new therapeutic principle for the treatment of hypertension.

Molecular Pharmacology published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chung, Yun Mi published the artcilePhenol-containing bis(oxazolines): synthesis and fluorescence sensing of amines, Category: bromides-buliding-blocks, the publication is Tetrahedron (2006), 62(50), 11645-11651, database is CAplus.

The fluorescence sensing of primary amines as their neutral forms was studied with bis(oxazolinyl)phenols (Me-BOP, Ph-BOP), which are efficiently synthesized starting from mesitylene in six steps and in overall 12-22% yields. The BOP sensors showed fluorescence enhancement toward butylamine and several arylethylamines, whereas they showed fluorescence quenching toward secondary and branched amines. The opposite fluorescence behavior is explained by an increased conformational restriction at the excited state, at which a proton transfer complex between the host and guest forms that is stabilized in a tripodal hydrogen bonding mode. This is the 1st example in which fluorescence enhancement is observed in amine sensing with phenolic fluorophores. Enantiomeric α-chiral organoamines were also sensed with different fluorescent intensity changes by Ph-BOP, complementing the previous tris(oxazolines) that sense enantiomeric α-chiral organoammonium ions.

Tetrahedron published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Reddy, K. Rajendar published the artcileCetyltrimethylammonium Bromide as an Efficient Catalyst for Regioselective Bromination of Alkoxy Naphthalenes with Trimethyl Benzyl Ammonium Tribromide: Synthetic and Kinetic Approach, Application In Synthesis of 111865-47-5, the publication is International Journal of Chemical Kinetics (2014), 46(1), 10-23, database is CAplus.

Bromination of 2-alkoxynaphthalene (2-ANP) and its derivatives with trimethylbenzylammonium tribromide (TMBATB) did not proceed smoothly even under reflux conditions. But the addition of microconcns. of cetyltrimethyl ammonium bromide (CTAB) to the reaction afforded dramatic rate accelerations as well as good-to-excellent yield of the products ranging from 70% to 90%. Reactions underwent regioselective monobromination at 1-position of 2-alkoxynaphthalene. The rate of bromination has been followed conductometrically. The reaction kinetics indicated first-order kinetics in [2-ANP] as well as in [TMBATB]. Kinetic results in the presence of CTAB were explained on the basis of the Raghavan-Srinivasan model as applied to micelle-mediated bimol. reactions.

International Journal of Chemical Kinetics published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application In Synthesis of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sparks, Richard B. published the artcileBenzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors, Quality Control of 111865-47-5, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(3), 736-740, database is CAplus and MEDLINE.

Benzothiazole benzimidazole (S)-isothiazolidinone ((S)-IZD) derivatives 5 were discovered through a peptidomimetic modification of the tripeptide (S)-IZD protein tyrosine phosphatase 1B (PTP1B) inhibitor 1. These derivatives are potent, competitive, and reversible inhibitors of PTP1B with improved caco-2 permeability. An X-ray co-crystal structure of inhibitor 5/PTP1B at 2.2 Å resolution demonstrated that the benzothiazole benzimidazole forms bi-dentate H-bonds to Asp48, and the benzothiazole interacts with the surface of the protein in a solvent exposed region towards the C-site. The design, synthesis, and SAR of this novel series of benzothiazole benzimidazole containing (S)-IZD inhibitors of PTP1B are presented herein.

Bioorganic & Medicinal Chemistry Letters published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C9H8BNO2, Quality Control of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dey, Rupa Rani published the artcileNovel Metal- and Mineral-Acid-Free Synthesis of Organic Ammonium Tribromides and Application of Ethylenephenanthrolium Bistribromide for Bromination of Active Methylene Group of 1,3-Diketones and β-Ketoesters, Application In Synthesis of 111865-47-5, the publication is Synthetic Communications (2015), 45(6), 714-726, database is CAplus.

A novel procedure for the preparation of organic ammonium tribromides (OATBs) is described from their corresponding bromides. Quaternary ammonium bromides (QABs) and a N,N’-heterocyclic dibromide are efficiently oxidized to their corresponding monotribromides and bistribromide by m-chloroperbenzoic acid (MCPBA) in the presence of 2 and 4 equiv of KBr, resp. The reactions are carried out in an aqueous medium without the use of any mineral acid or metal catalyst/promoters. A variety of tribromides are synthesized in very good yields including a hitherto unknown reagent, 1,10-(ethane-1, 2-diyl)phenanthrolinediium bistribromide (EPDBT). EPDBT is investigated as brominating agent and found to be highly effective for selective bromination of active methylene groups of a variety of 1,3-diketones and β-ketoesters.

Synthetic Communications published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application In Synthesis of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dey, Rupa R. published the artcileNovel protocol for the synthesis of organic ammonium tribromides and investigation of 1,1′-(ethane-1,2-diyl)dipiperidinium bis(tribromide) in the silylation of alcohols and thiols, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Chemistry Letters (2014), 43(10), 1545-1547, database is CAplus.

A novel and efficient protocol for the synthesis of organic ammonium tribromides (OATBs) is developed by using inexpensive and eco-friendly periodic acid as an oxidant for the conversion of Br^– to Br₃^–. The method does not use any mineral acid and metal oxidants. The protocol is utilized to synthesize a new bis(tribromide) viz., 1,1′-(ethane-1,2-diyl)dipiperidinium bis(tribromide) (EDPBT). EDPBT is investigated as a catalyst in the silylation of alcs. and thiols by HMDS (hexamethyldisilazane) under solvent-free conditions.

Chemistry Letters published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Miura, Yozo published the artcileMagnetic Interaction of Pyridyl-Substituted Thioaminyl Stable Free Radicals, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of Organic Chemistry (2003), 68(4), 1225-1234, database is CAplus and MEDLINE.

N-(2-Pyridylthio)-2,6-diaryl-4-R-phenylaminyls (R = Ph, 4-ClC₆H₄, MeCO, CN, EtOCO) and N-(4-pyridylthio)-2,6-diaryl-4-R-phenylaminyls (R = Ph, 4-ClC₆H₄, EtOCO) were prepared and isolated as radical crystals. Their ESR spectra were measured, and the NS and pyridyl N and anilino meta and pyridyl ortho and para proton hyperfine coupling constants were determined The spin-d. calculations based on the d. functional theory were performed by the UBecke 3LYP hybrid method using the STO 6-31G basis set. x-ray crystallog. analyses were performed for three radicals, and their structures were discussed. The magnetic susceptibility measurements were carried out for the nine kinds of isolated radicals with a SQUID magnetometer. One radical showed ferromagnetic coupling (2J/k_B = 44 K), and the others showed antiferromagnetic behavior. The magnetic interactions observed are explained from the crystal structures.

Journal of Organic Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Chang-chun published the artcileSelective bromination of p-hydroxybenzaldehyde, COA of Formula: C10H16Br3N, the publication is Huaxue Shijie (2008), 49(8), 481-483, database is CAplus.

The selective bromination of 4-hydroxybenzaldehyde (HBD) with benzyltrimethylammonium tribromide in dichloromethane-methanol was studied. A method for the synthesis of 3-bromo-4-hydroxybenzaldehyde is reported here. The effects of reaction conditions were determined When the mol ratio of 4-hydroxybenzaldehyde to benzyltrimethylammonium tribromide was 1.0:1.05, volume ratio of dichloromethane to methanol was 5:1, reaction temperature was 30° and reaction time was 1 h, the yield of monobromide reached 92.5% and the selectivity of monobromide reached 99%.

Huaxue Shijie published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, COA of Formula: C10H16Br3N.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary