Nino, Patricia; Cabaa, Marta; Aguilar, Nuria; Terricabras, Emma; Albericio, Fernando; Fernandez, Joan-Carles published an article in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. The title of the article was 《Efficient three-component synthesis of diversely substituted tetrahydro-1H-cyclopenta[c]quinolines》.Name: 4-Bromo-2-ethylbenzaldehyde The author mentioned the following in the article:
The synthesis of highly functionalized substituted tetrahydro-1H-cyclopenta[c]quinoline and its reduced derivatives hexahydro-1H-cyclopenta[c]quinolines via Povarov reaction in high diastereoselectivity and high to moderate yields is described. In addition, the relative stereochem. of the α-substituent to the tetrahydroquinoline nitrogen, as well as the regioselectivity of reaction, is shown to depend upon subtle substituent effects on the aldehyde and aniline precursors. In most cases, a preference for the formation of endo diastereomeric adducts is observed but for reactions with ortho-substituted aldehydes, the formation of exo adducts is also observed The exo-diastereoselectivity is found to be higher when the bulky size of this ortho group increases. Preparation of ortho and diortho-substituted aromatic aldehyde precursors of the Povarov reaction is also reported. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-ethylbenzaldehyde(cas: 1114808-89-7Name: 4-Bromo-2-ethylbenzaldehyde)
4-Bromo-2-ethylbenzaldehyde(cas: 1114808-89-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 4-Bromo-2-ethylbenzaldehyde Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary