Category: 111010-07-2

On December 9, 2021, Kaldor, Stephen W.; Tyhonas, John; Murphy, Eric A.; Kanouni, Toufike; Arnold, Lee D.; Kania, Robert; Cox, Jason M. published a patent.Safety of 5-Bromo-4-chloro-2-fluoroaniline The title of the patent was Pyrazolecarboxamides as inhibitors of fibroblast growth factor receptor kinases and their preparation. And the patent contained the following:

Provided herein are heteroaryl compounds as inhibitors of fibroblast growth factor receptor kinases, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases. Compounds of formula I wherein Z is (un)substituted alkenoyl, (un)substituted alkynoyl, (un)substituted cyanoacetyl, etc.; R is H, (un)substituted C1-6 alkyl, (un)substituted C3-7 carbocyclyl, (un)substituted C3-7 heterocyclyl, etc.; R4 is (un)substituted 9- to 10-membered heteroaryl; R6 is (un)substituted alkyl (un)substituted carbocyclylalkyl and (un)substituted heterocyclylalkyl; and pharmaceutically acceptable salts and solvates thereof, are claimed. Example compound II was prepared by coupling of 3-bromo-1-[(3S,5R)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)pyrazole-4-carboxamide and 5-ethynyl-2-methylbenzimidazole. The invention compounds were evaluated for their FGFR2 kinase inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of ≤ 0.10μM. The experimental process involved the reaction of 5-Bromo-4-chloro-2-fluoroaniline(cas: 111010-07-2).Safety of 5-Bromo-4-chloro-2-fluoroaniline

The Article related to pyrazolecarboxamide preparation fgfr2 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Safety of 5-Bromo-4-chloro-2-fluoroaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 26, 1987, Haga, Toru; Nagano, Hideyoshi; Okuda, Hiroki; Takase, Masayuki published a patent.Computed Properties of 111010-07-2 The title of the patent was Preparation of 5-bromo-4-chloro-2-fluoroaniline as intermediate for tetrahydrophthalimide herbicides. And the patent contained the following:

The title compound (I), useful as an intermediate for herbicidal tetrahydrophthalimides II (R = H, alkyl, Ph) were prepared by reduction of 1-bromo-2-chloro-4-fluoro-5-nitrobenzene (III). A mixture of 14 g III and 20 g Fe powder in AcOH 20, EtOAc 30, and 5% aqueous AcOH 50 mL was refluxed at 60-80° for 3 h to give 10.4 g I. The experimental process involved the reaction of 5-Bromo-4-chloro-2-fluoroaniline(cas: 111010-07-2).Computed Properties of 111010-07-2

The Article related to aniline trihalo preparation herbicide intermediate, herbicide intermediate bromochlorofluoroaniline preparation, phthalimide tetrahydro herbicide intermediate trihaloaniline, bromochlorofluoroaniline intermediate herbicide preparation and other aspects.Computed Properties of 111010-07-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 26, 1987, Haga, Toru; Nagano, Hideyoshi; Okuda, Hiroki; Takase, Masayuki published a patent.Computed Properties of 111010-07-2 The title of the patent was Preparation of 5-bromo-4-chloro-2-fluoroaniline as intermediate for tetrahydrophthalimide herbicides. And the patent contained the following:

The title compound (I), useful as an intermediate for herbicidal tetrahydrophthalimides II (R = H, alkyl, Ph) were prepared by reduction of 1-bromo-2-chloro-4-fluoro-5-nitrobenzene (III). A mixture of 14 g III and 20 g Fe powder in AcOH 20, EtOAc 30, and 5% aqueous AcOH 50 mL was refluxed at 60-80° for 3 h to give 10.4 g I. The experimental process involved the reaction of 5-Bromo-4-chloro-2-fluoroaniline(cas: 111010-07-2).Computed Properties of 111010-07-2

The Article related to aniline trihalo preparation herbicide intermediate, herbicide intermediate bromochlorofluoroaniline preparation, phthalimide tetrahydro herbicide intermediate trihaloaniline, bromochlorofluoroaniline intermediate herbicide preparation and other aspects.Computed Properties of 111010-07-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 10, 2022, Chen, Chen published a patent.Related Products of 111010-07-2 The title of the patent was Preparation of cyclic iminopyridimdine compounds and their bicyclic derivatives as kinase inhibitors and uses thereof. And the patent contained the following:

Provided are the title compounds I [G1 = N or CRa; G2 = N or CRb; n = 1 or 2; m = 0-3; Ra and Rb = (independently) H, halo, CN, etc.; each R1 = (independently) halo, (un)substituted alkyl, alkoxy; or two R1 groups with the carbon atom they connect to form (un)substituted 4-7 membered carbocyclic or heterocyclic ring; R2 = H, (un)substituted alkyl, alkoxy, etc.; R3 = H, halo, (un)substituted alkyl, alkoxy; R4 = H, (un)substituted alkyl, heterocyclyl, etc.; and R5 = H, alkyl, or heterocyclyl; or NR4R5 = (un)substituted heterocyclyl or heteroaryl; with the provisos] or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds or compositions, such as methods of treating a proliferation disorder, such as a cancer or a tumor, or in some embodiments disease or disorders related to the dysregulation of kinase such as, but not limited to kinases such as MAPK, PDGFR, Src, PAKs, c-Kit, EphA2, EphB4, FGFR, Axl, and c-Met. E.g., a multi-step synthesis of II, starting from 4-amino-2-(methylthio)pyrimidine-5-carboxaldehyde and Me 2-(2,4-dichlorophenyl)acetate, was described. The effect of the exemplified compounds I on the activity of various kinases were assessed (data given for representative compounds I). The experimental process involved the reaction of 5-Bromo-4-chloro-2-fluoroaniline(cas: 111010-07-2).Related Products of 111010-07-2

The Article related to cyclic iminopyrimidine bicyclic derivative preparation kinase inhibitor antitumor, mapk pdgfr src pak kinase inhibitor imidazopyridopyrimidinamine pyridodipyrimidinamine preparation, ckit epha2 ephb4 kinase inhibitor imidazopyridopyrimidinamine pyridodipyrimidinamine preparation antitumor and other aspects.Related Products of 111010-07-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary