Category: 1092349-87-5

Some common heterocyclic compound, 1092349-87-5, name is 2-Bromo-3,4-difluoroaniline, molecular formula is C6H4BrF2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Bromo-3,4-difluoroaniline

To a solution of 2-bromo-3,4-difluoroaniline (7.0 g, 33.65 mmol) in pyridine was added TsCl (6.72 g, 35.3 mmol) at <30 C. in 20 min. After being stirred at rt for overnight, ice-cold water (400 mL) was added to the reaction mixture. Then the mixture was filtrated and washed with H2O (3¡Á100 mL). The filter cake was dissolved in EA, dried over Na2SO4 for 30 min, concentrated under vacuum to provide the title compound (11.6 g). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1092349-87-5, its application will become more common. Reference:
Patent; Enanta Pharmaceuticals, Inc.; Kim, In Jong; yu, Jianming; Panarese, Joseph; McGrath, Kevin; Negretti-Emmanuelli, Solymar; Blaisdell, Thomas P.; Shook, Brian C.; Or, Yat Sun; US2019/2479; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1092349-87-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1092349-87-5 as follows.

To a stirred solution of 2-bromo-4,5-difluoroaniline [H. Ishikawa, T. Uno, H, Miyamoto, H. Hiraki, H. Tamaoka, M. Tominaga and K. Nakagawa, Chem. Pharm. Bull., 1990, 38(9), 2459-2462] (72 g, 34 mmol) in ether (50 mL) at 0 C. was added sodium carbonate (5.4 g, 44 mmol) and trifluoroacetic anhydride (6.2 mL, 44 mmol). The reaction mixture was stirred at room temperature for 1 h. Water (100 mL) was added and the mixture was extracted with dichloromethane (3*100 mL). The organic extracts were combined, dried (magnesium sulfate), filtered and concentrated in vacuo to give the product (9.9 g, 94%) as a white solid. IR numax (Nujol)/cm-1 3270, 1716, 1550, 1489, 1465, 1226, 1181, 919, 876 and 821; NMR deltaH (400 MHz, CDCl3) 7.45-7.5 (1H, dd, J 7.5 Hz), 8.28-8.34 (1H, dd, J 8 Hz) and 8.36 (1H, br s).

According to the analysis of related databases, 1092349-87-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Vernalis Research Limited; US6706750; (2004); B1;,
Bromide – Wikipedia,
bromide – Wiktionary