Category: 108940-96-1

Facile, direct reaction of benzaldehydes to 3-arylprop-2-enoic acids and 3-arylprop-2-ynoic acids in aqueous medium was written by Thiemann, Thies;Elshorbagy, Mohamed W.;Salem, Mostafa H. F. A.;Ahmadani, Siraj A. N.;Al-Jasem, Yosef;Al Azani, Mariam;Al-Sulaibi, Mazen A. M.;Al-Hindawi, Bassam. And the article was included in International Journal of Organic Chemistry in 2016.Recommanded Product: 3,5-Dibromo-4-methoxybenzaldehyde This article mentions the following:

Wittig reactions of benzaldehydes, alkanals, and cycloalkanals as well as of acetophenones are carried out with alkoxycarbonyl methylidenetriphenylphosphoranes in 10 w% aqueous NaOH, where the cinnamates and alkenoates produced are hydrolyzed in situ and the corresponding acids are obtained after mostly simple extractive work-up, often without employing organic solvents. Under the same conditions, benzaldehydes are reacted with alkoxycarbonyl bromomethylidenephosphorane to produce 3-arylprop-2-ynoic acids (arylpropiolic acids). In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Recommanded Product: 3,5-Dibromo-4-methoxybenzaldehyde).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 3,5-Dibromo-4-methoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and evaluation of cadiolide analogues as inhibitors of bacterial biofilm formation was written by Mairink, Simone Z.;Barbosa, Luiz C. A.;Boukouvalas, John;Pedroso, Silvia H. S. P.;Santos, Simone G.;Magalhaes, Paula P.;Farias, Luiz M.. And the article was included in Medicinal Chemistry Research in 2018.Computed Properties of C8H6Br2O2 This article mentions the following:

Bacterial biofilm infections pose a major clin. challenge due to the ability of biofilms to resist high levels of conventional antibiotics. In the present study, we describe the synthesis and biofilm inhibiting properties of nine new butenolides related to the cadiolide family of marine antibiotics. Eight new cadiolide analogs were synthesized using oxazole-ynone Diels-Alder cycloaddition/cycloreversion as the key step. Their effects on bacterial growth and biofilm formation were investigated against a range of Gram-pos. and Gram-neg. bacteria, namely Staphylococcus aureus, Enterococcus faecalis, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. The cadiolide analogs strongly inhibited biofilm formation of the two Gram-pos. bacteria (S. aureus and E. faecalis) at concentrations as low as 0.3 娓璯 mL^-1 and 0.5 娓璯 mL^-1, resp. The identification of synthetic cadiolides with potent biofilm-inhibiting capabilities opens a new avenue for therapeutic interventions and highlights the potential of this class of compounds for antimicrobial drug development. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Computed Properties of C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Aplysinadiene and (R,R)-5-[[3,5-dibromo-4-[(2-oxo-5-oxazolidinyl)]methoxy]phenyl]-2-oxazolidinone, two novel metabolites from Aplysina aerophoba. Synthesis of aplysinadiene was written by Norte, M.;Rodriguez, M. L.;Fernandez, J. J.;Eguren, L.;Estrada, D. M.. And the article was included in Tetrahedron in 1988.Reference of 108940-96-1 This article mentions the following:

Two novel constituents, biogenetically derived from dibromotyrosine, were obtained from a sponge Aplysina鑱?em>aerophoba. The structure of aplysinadiene (I) was established on the basis of its spectral properties and by synthesis of I and its isomers (1′E)- and (1′Z)-II. The structure and absolute configuration of the oxazolidinone III was established by x-ray diffraction anal. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Reference of 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of lipophilic bisanthracene fluorophores: versatile building blocks toward the synthesis of new light-harvesting dendrimers was written by Takahashi, Masaki;Yamamoto, Ayato;Inuzuka, Toshiyasu;Sengoku, Tetsuya;Yoda, Hidemi. And the article was included in Tetrahedron in 2011.Synthetic Route of C8H6Br2O2 This article mentions the following:

Lipophilic bisanthracene-based fluorophore and its derivatives were synthesized by the Suzuki-Miyaura cross-coupling reaction of 9-anthrylboronic acid with a substituted dibromobenzene. In addition to desirable fluorescent properties, these mol. systems were demonstrated to serve as versatile building blocks toward the synthesis of two types of new light-harvesting dendrimers due to their chem. stability. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Synthetic Route of C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors was written by Connelly, Stephen;Mortenson, David E.;Choi, Sungwook;Wilson, Ian A.;Powers, Evan T.;Kelly, Jeffery W.;Johnson, Steven M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.SDS of cas: 108940-96-1 This article mentions the following:

Rate-limiting dissociation of the tetrameric protein transthyretin (TTR), followed by monomer misfolding and misassembly, appears to cause degenerative diseases in humans known as the transthyretin amyloidoses, based on human genetic, biochem. and pharmacol. evidence. Small mols. that bind to the generally unoccupied thyroxine binding pockets in the native TTR tetramer kinetically stabilize the tetramer, slowing subunit dissociation proportional to the extent that the mols. stabilize the native state over the dissociative transition state-thereby inhibiting amyloidogenesis. Herein, the authors use previously reported structure-activity relationship data to develop two semi-quant. algorithms for identifying the structures of potent and selective transthyretin kinetic stabilizers/amyloidogenesis inhibitors. The viability of these prediction algorithms, in particular the more robust in silico docking model, is perhaps best validated by the clin. success of tafamidis, the first-in-class drug approved in Europe, Japan, South America, and elsewhere for treating transthyretin aggregation-associated familial amyloid polyneuropathy. Tafamidis is also being evaluated in a fully-enrolled placebo-controlled clin. trial for its efficacy against TTR cardiomyopathy. These prediction algorithms will be useful for identifying second generation TTR kinetic stabilizers, should these be needed to ameliorate the central nervous system or ophthalmol. pathol. caused by TTR aggregation in organs not accessed by oral tafamidis administration. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1SDS of cas: 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.SDS of cas: 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chemoselective and metal-free reduction of α,β-unsaturated ketones by in situ produced benzeneselenol from O-(tert-butyl) Se-phenyl selenocarbonate was written by Temperini, Andrea;Ballarotto, Marco;Siciliano, Carlo. And the article was included in RSC Advances in 2020.HPLC of Formula: 108940-96-1 This article mentions the following:

The carbon-carbon double bond of arylidene acetones and chalcones can be selectively reduced with benzeneselenol generated in situ by reacting O-(tert-butyl) Se-Ph selenocarbonate with hydrochloric acid in ethanol. This mild, metal-free and exptl. simple reduction procedure displays considerable functional-group compatibility, products are obtained in good to excellent yields, and the use of toxic Se/CO mixture and NaSeH, or the smelly and air-sensitive benzeneselenol, is avoided. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1HPLC of Formula: 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of polycitrin A and 3,4-bis(4-hydroxyphenyl)pyrrole derivatives related to polycitone A was written by Winklhofer, Christian;Terpin, Andreas;Peschko, Christian;Steglich, Wolfgang. And the article was included in Synthesis in 2006.Name: 3,5-Dibromo-4-methoxybenzaldehyde This article mentions the following:

The oxidative condensation of 3-arylpyruvic acids, e.g. I, with arylethylamines, e.g. 4-MeOC₆H₄CH₂CH₂NH₂, to give 3,4-diarylpyrrole-2,5-dicarboxylic acids, e.g. II (R = OH) , was used for an efficient synthesis of polycitrin A (III). Investigation of the bromine-mediated degradation of acid II (R = OH) to maleimide IV (R¹₂ = O) suggested that the corresponding 2,5-dibromopyrrole and 5,5-dimethoxy-3-pyrroline-2-one IV (R¹ = MeO) are intermediates in this process. The debromo analog of polycitone A V was prepared in two steps from pyrrole dicarboxylic acid diester II (R = EtO). In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Name: 3,5-Dibromo-4-methoxybenzaldehyde).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 3,5-Dibromo-4-methoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regioselective monobromination of aromatics via a halogen bond acceptor-donor interaction of catalytic thioamide and N-bromosuccinimide was written by Bovonsombat, Pakorn;Teecomegaet, Pattaradra;Kulvaranon, Panisanun;Pandey, Aditi;Chobtumskul, Kittithorn;Tungsirisurp, Sireethorn;Sophanpanichkul, Punyanuch;Losuwanakul, Satreerat;Soimaneewan, Dechathon;Kanjanwongpaisan, Patcharida;Siricharoensang, Pornpawit;Choosakoonkriang, Sirirat. And the article was included in Tetrahedron in 2017.Synthetic Route of C8H6Br2O2 This article mentions the following:

Regioselective monobromination of various aromatics was achieved at room temperature using N-bromosuccinimide and 5 mol% of thioamides in acetonitrile. With thiourea as catalyst, activated aromatics, such as anisole, acetanilide, benzamide and phenol analogs containing electron donating or withdrawing groups, were brominated with high regioselectivity. Room temperature brominations of weakly activated aromatics and deactivated 9-fluorenone were accomplished by 5 mol% thioacetamide, higher substrates concentrations and longer reaction times. A backbonding of the bromine lone pairs with the π^*of C=S group and a halogen bond between the halogen bond donor bromine and the halogen bond acceptor sulfur of the thioamide are thought to be the principal interactions and cause of N-bromosuccinimide activation. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Synthetic Route of C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Synthetic Route of C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells was written by Valente, Sergio;Lepore, Ilaria;Dell’Aversana, Carmela;Tardugno, Maria;Castellano, Sabrina;Sbardella, Gianluca;Tomassi, Stefano;Di Maro, Salvatore;Novellino, Ettore;Di Santo, Roberto;Costi, Roberta;Altucci, Lucia;Mai, Antonello. And the article was included in Biochimie in 2012.Related Products of 108940-96-1 This article mentions the following:

Chem. manipulations undertaken on some bis(bromo- and dibromo-phenol) compounds previously reported by us as wide-spectrum epigenetic inhibitors let us to identify bis (bromo- and dibromo-methoxyphenyl) derivatives highly selective for PR-SET7 and EZH2 (compounds 4, 5, 9, and 10). Western blot analyses were carried out in U937 cells to determine the effects of such compounds on the Me marks related to the tested enzymes (H3K4me1, H3K9me2, H4H20me1, and H3K27me3). The 1,5-bis(3-bromo-4-methoxyphenyl)penta-1,4-dien-3-one 4 (EC₅₀ vs EZH2 = 74.9 μM), tested in U937 cells at 50 μM, induced massive cell death and 28% of granulocytic differentiation, highlighting the potential use of EZH2 inhibitors in cancer. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Related Products of 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase was written by Ullah, Nisar;Haladu, Shamsuddeen A.;Mosa, Basem A.. And the article was included in Tetrahedron Letters in 2011.Name: 3,5-Dibromo-4-methoxybenzaldehyde This article mentions the following:

An improved total synthesis of spermatinamine (I), an inhibitor of the anticancer target isoprenylcysteine carboxy methyltransferase (no biol. testing data presented), was accomplished starting from the com. available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Name: 3,5-Dibromo-4-methoxybenzaldehyde).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 3,5-Dibromo-4-methoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary