Category: 1074-24-4

Adding a certain compound to certain chemical reactions, such as: 1074-24-4, name is 1,4-Dibromo-2,5-dimethylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1074-24-4, Computed Properties of C8H8Br2

1,4-dibromo-2,5-dimethylbenzene: 1H-1,2,4-triazole: potassium carbonate: cupric oxide molar ratio is 2:10:30:1In a 50 ml three-necked round-bottom flask equipped with magnetic stirrer, reflux condenser and thermometer, add CuO (0.0398 mg, 0 . 5mmol), potassium carbonate (2.0731g, 15mmol), 1H-1,2,4-triazole (0.345 mg, 5mmol), 1,4-dibromo-2,5-dimethylbenzene (0.3360g, 1mmol), 20mL DMF. Start stirring at 100 deg.C. React for 24 hours. After the reaction, the reaction liquid to room temperature, filtered, the filtrate by adding 100 ml water, precipitating a large amount of precipitation, filtration, collection filter cake, the yield is 60percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,4-Dibromo-2,5-dimethylbenzene, and friends who are interested can also refer to it.

Reference:
Patent; Tianjin Normal University; Wang, Ying; (12 pag.)CN105669719; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1074-24-4,Some common heterocyclic compound, 1074-24-4, name is 1,4-Dibromo-2,5-dimethylbenzene, molecular formula is C8H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,4-dibromo-2,5-dimethylbenzene: 1H-1,2,4- triazole: potassium carbonate: copper oxide molar ratio is 2: 10: 30: 1. To a 50mL three-neck round bottom flask equipped with a magnetic stirrer, reflux condenser and thermometer was added CuO (0.0398mg,0.5mmol), potassium carbonate (2.0731g, 15mmol), 1H-1,2,4-triazole (0.345mg, 5mmol), 1,4- dibromo-2,5-dimethylbenzene (0.3360g, 1mmol ), 20mL DMF. Stirring at 100 deg.C. React for 24 hours. After completion of the reaction, the reaction solution was cooled to room temperature, filtered and the filtrate was added 100mL of water, heavy precipitate precipitation, filtration, filter cake was collected, yield 60percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2,5-dimethylbenzene, its application will become more common.

Reference:
Patent; Tianjin Normal University; Wang, Ying; (11 pag.)CN105669720; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 1074-24-4,Some common heterocyclic compound, 1074-24-4, name is 1,4-Dibromo-2,5-dimethylbenzene, molecular formula is C8H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 1,4-dibromo-2,5-dimethylbenzene (5.0 g, 18.94 mmol, Aldrich) in anhydrous THF (20 mL) was cooled to about -10° C. Isopropyl magnesium chloride (3.95 mL, 2.0 M in THF, 7.9 mmol) was added. The mixture was allowed to stir at about -10° C. for about 0.25 h. Next n-butyl lithium (6.31 mL, 2.5 M in hexanes, 15.8 mmol) was added dropwise keeping the temperature at or below about 0° C. Once the addition was complete the reaction was stirred at about -10° C. for about 1 h. Next a solution of DMF in 10 mL anhydrous THF (20.52 mmol) was added dropwise keeping the temperature at or below about 0° C. The reaction was stirred at ambient temperature for about 3 hours. The reaction was poured into about 50 mL of about 5 M aqueous citric acid solution (exothermic) and stirred at room temperature for about 10 minutes. The layers were separated and the aqueous layer was extracted once with toluene (50 mL). The combined organic layers were washed with water (20 mL), then concentrated in vacuo. The residue was purified by column chromatography (SiO2, diethyl ether/petroleum ether 5:95) to give 4-bromo-2,5-dimethylbenzaldehyde (3.66 g, 17.18 mmol, 91percent) as a pale crystalline solid: 1H-NMR (CDCl3, Bruker 400 MHz) delta 2.43 (3H, s); 2.60 (3H, s); 7.47 (1H, s); 7.63 (1H, s) 10.2 (1H, s).

The synthetic route of 1074-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBVIE INC.; Cusack, Kevin P.; Gordon, Thomas D.; Hoemann, Michael Z.; Ihle, David C.; Li, Bin; Lo Schiavo, Gloria Y.; Somal, Gagandeep K.; Friedman, Michael; Hayes, Martin E.; Bakker, Wouter Iwema; US2014/179676; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 1074-24-4, name is 1,4-Dibromo-2,5-dimethylbenzene, molecular formula is C8H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1074-24-4

1, 4-dibromo-2,5-dimethylbenzene: 1H-1,2,4-triazole: potassium carbonate: copper oxide molar ratio of 2: 10: 30: 1A solution of CuO (0.0398 mg, 0.5 mmol), potassium carbonate (2.0731 g, 15 mmol), 1H-1,2,4-triazole (0.345 g, 0.5 mmol), and triethylamine Mg, 5 mmol), 1,4-dibromo-2,5-dimethylbenzene (0.3360 g, 1 mmol), 20 mL of DMF. Stirring was started at 100oC for 24 hours. After the completion of the reaction, the reaction solution was cooled to room temperature, filtered, and the filtrate was added with 100 mL of water. A large amount of precipitate was precipitated, and the filter cake was collected by suction filtration at a yield of 60percent. Elemental analysis (C12N6H12) Calcd. (percent): C, 59.99; H, 5.03; N, 34.98. Found: C, 60.02; H, 5.05; N, 35.05;1,4-dibromo-2,5-dimethylbenzene 1H-1,2,4-triazole.In the present invention, the molar ratio of 1,4-dibromo-2,5-dimethylbenzene: 1H-1,2,4-triazole: potassium carbonate:2: 10: 30: 1; reaction temperature 80-200 , reaction time 12-120 hours. The organic compound was prepared by heating 1,4-dibromo-2,5-dimethylbenzene and 1H-1,2,4-triazole in a one-pot process. 1- (2,5- Dimethyl-4- (1H-1,2,4-Triazol-1-yl) phenyl) -1H-1,2,4-triazole (L).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1074-24-4, its application will become more common.

Reference:
Patent; Tianjin Normal University; Wang, Ying; (12 pag.)CN105418659; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1074-24-4,Some common heterocyclic compound, 1074-24-4, name is 1,4-Dibromo-2,5-dimethylbenzene, molecular formula is C8H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 100 ml flask, with a magnetic stirrer, thermometer and coolant, in an inert atmosphere, the following were loaded, in order: 1 ,4-dibromo-2,5-dimethybenzene (Aldrich) (13.20 g; 50.0 mmoles) [dihalogenated acrylic compound having general formula (II) wherein Rn = methyl and X = bromine] and carbon tetrachloride (Aldrich) (1590 ml) and, after heating to reflux temperature, for 5 minutes, a bromine solution (Aldrich) (10.80 ml; 210 mmoles) in carbon tetrachloride (Aldrich) (50 ml) was added, by dripping: the reaction mixture obtained was maintained at reflux temperature, under stirring, and subjected to radiation with an incandescent lamp at 500 W (UV radiation emitted at 300 nm), for 4 hours. Subsequently, after cooling to room temperature (25°C), the reaction mixture obtained was placed in a 500 ml separator funnel: a concentrated aqueous solution of sodium bisulfite (NaHSOs) (Aldrich) (3 x 100 ml) and deionized water (Aldrich) (3 x 100 ml) was added to said reaction mixture and everything was extracted, obtaining an acidic aqueous phase and an organic phase. The entire organic phase (obtained by joining the organic phases deriving from the three extractions) was subsequently anhydrified on sodium sulfate (Aldrich) and evaporated. The residue obtained was recrystallized from ethyl acetate (Aldrich) (50 ml), obtaining 26.04 g of 1 ,4-dibromo-2,5- bis(dibromomethyl)benzene having formula (III) as white crystals (yield 89percent).

The synthetic route of 1074-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ENI SPA; BIANCHI, Gabriele; PASINI, Dario; NITTI, Andrea; (67 pag.)WO2019/175367; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1074-24-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1074-24-4 as follows.

Iodine (78 mg, 0.33 mmol) was added to p-xylene (6.13 mL, 50.0 mmol), the mixture was cooled to 0 °C, and bromine (5.20 mL, 101 mmol) was added dropwise over 10 min. The ice bath was removed and the reaction stirred at rt for 16 h in the absence of light. The reaction was quenched with 20percent aq. KOH and stirred for 15 min while the solution became colorless. The solid precipitate was filtered and rinsed 2 x with 100 mL of H2O. The solids were recrystallized in ethanol to afford a white solid (9.19 g, 70percent). 1H NMR (CDCl3): delta 7.40 (s, 2H), 2.34 (s, 6H). 1,4?dibromo-2,5-dimethylbenzene (5.93 g, 22.5 mmol) and KMnO4 (15.72 g, 99.5 mmol) were added to 80 mL of t-BuOH:H2O (1:1). Celite (14 g) was added to the flask and the reaction was refluxed for 18 h. The reaction mixture was cooled to rt, filtered over celite and the filter was washed with hot H2O (100mL) and EtOAc (50mL). The filtrate was then acidified to pH=1 with conc. HCl. The white suspension was then extracted 3x with 100 mL of EtOAc. The combined organic extracts were dried over MgSO4 and excess solvent was removed under vacuum to obtain a white solid (3.06 g, 42percent) which was not purified further. 1H NMR (DMSO-d6): delta 8.01 (s, 2H). 2,5?dibromoterephthalic acid (2.04 g, 6.30 mmol) dissolved in 35 mL of MeOH and refluxed for 30 min. Thionyl chloride (9.00 mL, 124 mmol) was then carefully added and the reaction was refluxed 12 hours. The reaction flask was cooled to room temperature, 50 mL of water was carefully added, and the reaction was extracted 3x with 75 mL of Et2O. The combined organics were washed with 3 x with 50 mL of sat. NaHCO3 and dried with MgSO4. The solvent was removed under vacuum and the solids recrystallized in MeOH to yield a white crystalline solid (1.65g, 74percent), mp = 134-136 C (lit.3 mp 134-137 C). 1H NMR (CDCl3): delta 8.06 (s, 2H), 3.96 (s, 6H). The 1H NMR matches the known spectrum.3

According to the analysis of related databases, 1074-24-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Dressler, Justin J.; Miller, Sarah A.; Meeuwsen, Brian T.; Riel, Asia Marie S.; Dahl, Bart J.; Tetrahedron; vol. 71; 2; (2015); p. 283 – 292;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 1074-24-4, name is 1,4-Dibromo-2,5-dimethylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1074-24-4, COA of Formula: C8H8Br2

1,4-dibromo-2,5-dimethylbenzene: 1H-1,2,4-triazole: potassium carbonate: copper oxide molar ratio is 2: 10: 30: 1. A 50mL three-neck round bottom flask equipped with a magnetic stirrer, reflux condenser and thermometer was added CuO (0.0398mg,0.5mmol), potassium carbonate (2.0731g, 15mmol), 1H-1,2,4-triazole (0.345mg, 5mmol), 1,4- dibromo-2,5-dimethylbenzene (0.3360g, 1mmol ), 20mL DMAC. Start stirring at 100 deg.C and react for 24 hours. After completion of the reaction, the reaction solution was cooled to room temperature, filtered and the filtrate was added 100mL of water, heavy precipitate precipitation, filtration, filter cake was collected, yield 60percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2,5-dimethylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tianjin Normal University; Wang, Zhongliang; Wang, Ying; (12 pag.)CN105732719; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1074-24-4, name is 1,4-Dibromo-2,5-dimethylbenzene, A new synthetic method of this compound is introduced below., Formula: C8H8Br2

Under a nitrogen stream 2,5-dibromo-p-xylene (25.0 g, 94.71 mmol) is added to diethylether (350 mL), the temperature is lowered to -78 ¡ã C, and then 2.5 M n-BuLi (31.5 g, 113.6 mmol) is added slowly. After the temperature was raised to room temperature, the mixture was stirred for 1 hour, and then DMF (8.3 g, 113.65 mmol) was added slowly at -78 ¡ã C, followed by stirring at room temperature for 12 hours. To terminate the reaction, the reaction mixture is poured into water and extracted with diethylether. The organic layer is washed with MgSO4 to remove water and the solvent is removed. A white solid was obtained using a silica column (Hexane). (15.6 g, 71percent). 1H NMR (300 MHz, CDCl3, delta): 10.12(s, 1H), 7.38(s, 1H), 7.30(s, 1H), 2.35(s, 6H).

The synthetic route of 1074-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Korea Institute of Industrial Technology; Lee, Young Chul; Kim, Myung Jun; Kim, Baek Jin; Hwang, Suk Ho; Jung, Sung Wook; Kim, Chang Joo; (13 pag.)KR101610235; (2016); B1;,
Bromide – Wikipedia,
bromide – Wiktionary