Application of 105679-22-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 105679-22-9, name is 7-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine, This compound has unique chemical properties. The synthetic route is as follows.
Step B: ethyl 9-bromo-7-hydroxy-5-oxo-3,5-dihydro-2H-[l,4]oxazino[2,3,4-ij]quinoline-6- carboxylate A mixture of 7-bromo-3,4-dihydro-2H-benzo[b][l,4]oxazine (760 mg, 3.55 mmol) and triethyl methanetricarboxylate (3298 mg, 14.20 mmol) was heated to 250 C and stirred for 0.5 h. The resulting mixture was cooled to room temperature. The product was recrystallised from petroleum ether (50 mL) to give ethyl 9-bromo-7-hydroxy-5-oxo-3,5-dihydro-2H- [l,4]oxazino[2,3,4-ij]quinoline-6-carboxylate as a solid. XH NMR (CDC13, 400 MHz): delta 14.25 (s, 1H), 7.88 (d, J= 1.6 Hz, 1H), 7.33 (d, J= 1.6 Hz, 1H), 4.52 (q, J= 6.8 Hz, 14.0 Hz, 2H), 4.36 (t, J= 5.2 Hz, 2H), 4.21 (t, J= 5.2 Hz, 2H), 1.49 (t, J= 6.8 Hz, 3H).
The chemical industry reduces the impact on the environment during synthesis 7-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO., LTD.; CAI, Jiaqiang; CRESPO, Alejandro; DU, Xiaoxing; DUBOIS, Byron Gabriel; GUIADEEN, Deodialsingh; KOTHANDARAMAN, Shankaran; LIU, Ping; LIU, Rongqiang; QUAN, Weiguo; SINZ, Christopher; WANG, Liping; (285 pag.)WO2016/49099; (2016); A1;,
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