Category: 105309-59-9

Synthetic Route of 105309-59-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 105309-59-9 name is Tetrakis(4-bromophenyl)methane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Cz (2.5 g, 8.9 mmol), intermediate TBrBen (2.8 g, 4.5 mmol), CuI (0.19 g, 1.0 mmol) and K3PO4 (1.69 g, 8.0 mmol) were added to 100 mL of toluene.The reaction was carried out under argon gas protection and reflux for 24 hours.After removing the solvent, the residue was extracted with dichloromethane (3×100 mL).The organic phases were combined and dried over anhydrous magnesium sulfate.The residue obtained by concentration was purified by column chromatography using dichloromethane: n-hexane (7:3) as eluent to afford product DCzCBr (2.7 g, yield 50.3%).Identification of intermediates by mass spectrometry,The result is:

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Tetrakis(4-bromophenyl)methane, and friends who are interested can also refer to it.

Reference:
Patent; Yangtze Normal University; Yang Yezi; Yao Chuang; Sun Changqing; (13 pag.)CN108752320; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 105309-59-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 105309-59-9 name is Tetrakis(4-bromophenyl)methane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Cz (2.5 g, 8.9 mmol), intermediate TBrBen (2.8 g, 4.5 mmol), CuI (0.19 g, 1.0 mmol) and K3PO4 (1.69 g, 8.0 mmol) were added to 100 mL of toluene.The reaction was carried out under argon gas protection and reflux for 24 hours.After removing the solvent, the residue was extracted with dichloromethane (3×100 mL).The organic phases were combined and dried over anhydrous magnesium sulfate.The residue obtained by concentration was purified by column chromatography using dichloromethane: n-hexane (7:3) as eluent to afford product DCzCBr (2.7 g, yield 50.3%).Identification of intermediates by mass spectrometry,The result is:

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Tetrakis(4-bromophenyl)methane, and friends who are interested can also refer to it.

Reference:
Patent; Yangtze Normal University; Yang Yezi; Yao Chuang; Sun Changqing; (13 pag.)CN108752320; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 105309-59-9, name is Tetrakis(4-bromophenyl)methane, A new synthetic method of this compound is introduced below., Application In Synthesis of Tetrakis(4-bromophenyl)methane

(a) Add tetra-[4-bromo-phenyl]methane 0.636 g (1 mmoL) and tetrakistriphenylphosphine palladium 0.18 g to a 50 mL two-necked round bottom flask and add toluene/tetrahydrofuran mixed solvent 20 mL under a vacuum of nitrogen. (volume ratio is 1:1), stir and dissolve uniformly, then inject 3-butylthiophene tributyl group 3.642g (8mmoL), raise the temperature to 140C, and react for 24 hours under light-proof conditions. After the reaction was completed, the mixture was extracted with methylene chloride, and the extract was spin-dried and separated by a column. Silica gel was used as a filler, and petroleum ether and methylene chloride (4:1 by volume) were used as eluent to give a pale yellow product (0.39 g). The yield is 40%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zhejiang University of Technology; Zhang Cheng; Dai Yuyu; Li Weijun; Yan Shuanma; Qu Xingxing; Chen Lan; (11 pag.)CN107188902; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 105309-59-9, name is Tetrakis(4-bromophenyl)methane, A new synthetic method of this compound is introduced below., HPLC of Formula: C25H16Br4

B is prepared according to the procedure described in reference 5.[0186] A 250 mL Schlenk flask was charged with A (4g, 6.3 mmol), B (6.79 g, 37.7 mmol), CsF (9.5 g, 63.9 mmol),and Pd(P(Ph)3)4 0.3 g. 120 ml DME was degassed and transferred. A water condenser was then equipped. The flaskwas heated to reflux under the nitrogen for 48 hours. The solvent was dried on rotary evaporator. The residue wasdissolved by CH2Cl2, and purified by column chromatography to get C 4.1g (Yield. 76%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THE TEXAS A&M UNIVERSITY SYSTEM; Zhou, Hong-Cai; Feng, Dawei; Wang, Kecheng; EP2876112; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 105309-59-9, A common heterocyclic compound, 105309-59-9, name is Tetrakis(4-bromophenyl)methane, molecular formula is C25H16Br4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of Ar-X (2.0 mmol), TeocNHOTBS (3; 640 mg, 2.2 mmol), Bippyphos (2; 51 mg, 0.10 mmol), and Pd2dba3 (23 mg, 0.025 mmol) in toluene (8 mL) was treated with Cs2CO3 (1.3 g, 4.0 mmol). N2 was bubbled through the mixture for 30 min, and then the mixture was heated and stirred at 80 C for 16 h under N2. The resulting mixture was purified directly by column chromatography (EtOAc/hexanes).

The synthetic route of 105309-59-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Beaudoin, Daniel; Wuest, James D.; Tetrahedron Letters; vol. 52; 17; (2011); p. 2221 – 2223;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 105309-59-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105309-59-9, name is Tetrakis(4-bromophenyl)methane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A 250 mE Schlenk flask was charged with A (4 g,6.3 mmol), 13 (6.79 g, 37.7 mmol), CsF (9.5 g, 63.9 mmol),and Pd(P(Ph)3)4 0.3 g. 120 ml DME was degassed and transferred. A water condenser was then equipped. The flask washeated to reflux under the nitrogen for 48 hours. The solventwas dried on rotary evaporator. The residue was dissolved byCH2C12, and purified by column chromatography to get C 4.1g (Yield. 76%).

The synthetic route of Tetrakis(4-bromophenyl)methane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhou, Hong-Cai; Feng, Dawei; Wang, Kecheng; US2015/152123; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 105309-59-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105309-59-9, name is Tetrakis(4-bromophenyl)methane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The H4MTBC bridging ligand was prepared in two steps as shown in FIG. 11. First, the intermediate tetramethyl 4?,4??,4???,4????-methanetetrayltetrakis([1,1?-biphenyl]-4-carboxylate) (Me4MTBC) (CAS: 1208241-39-7) was synthesized using a modified procedure from the literature. Tetrakis(4-bromophenyl)methane (723 mg, 1.14 mmol, 1 equiv.), Pd(PPh3)4 (132 mg, 0.114 mmol, 0.1 equiv.), 4-(methoxycarbonyl)phenylboronic acid (1.23 g, 6.82 mmol, 6 equiv.) and CsF (3.11 g, 20.46 mmol, 18 equiv.) were charged in a 120 mL high-pressure reaction tube and pumped into an N2 glove box. To the reaction tube was added 60 mL of degassed dimethoxyethane, and the tube was capped and stirred at 85 C. for 3 days. Progress of the reaction was monitored by thin layer chromatography (TLC) (1% EtOAc/CHCl3). After cooling to room temperature, the reaction mixture was transferred to a round-bottom flask and evaporated with a rotavap. The resulting solid was dissolved with CHCl3 and filtered through celite to remove CsF and Pd nanoparticles. The filtrate was evaporated with a rotavap, then purified by flash column chromatography on silica gel using 1% EtOAc/Hexane as eluent to give white solid as pure product (572 mg, 59% yield). 1H NMR (500 MHz, CDCl3): delta 8.10 (d, 3JH=8.3 Hz, 8H), 7.68 (d, 3JHH=8.3 Hz, 8H), 7.59 (d, 3JHH=8.4 Hz, 8H), 7.44 (d, 3JHH=8.5 Hz, 8H), 3.94 (s, 12H).

The synthetic route of Tetrakis(4-bromophenyl)methane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The University of Chicago; Lin, Wenbin; Manna, Kuntal; Ji, Pengfei; (83 pag.)US2018/361370; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 105309-59-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 105309-59-9 name is Tetrakis(4-bromophenyl)methane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of tetrakis(4-bromophenyl)methane (0.6360 g,1 mmol) and N-(tert-butoxycarbonyl)-pyrrol-2-ylboronic acid(1.0128 g, 4.8 mmol) in 30 mL of THF was added 10 mL of a saturatedaqueous solution of potassium carbonate, and then degassedby bubbling nitrogen gas for 15 min. After adding Pd(PPh3)4 (57 mg,0.05 mmol) under a nitrogen atmosphere, the reaction mixturewasstirred at 80 C for 12 h, and then cooled to room temperature. Theresulting mixture was extracted with ethyl acetate three times. Thecombined organic layer was washed with deionized water anddried over sodium sulfate. After concentration under reducedpressure, the residual oil was purified by column chromatographyusing n-hexane: ethyl acetate (30: 1) as the eluent to give thedesired product as a light yellow solid in 81% yield. 1H NMR(400 MHz, DMSO-d6, d): 7.35 (t, J 2.0 Hz, 4 H), 7.30 (d, J 8.0 Hz,8 H), 7.26 (d, J 8.0 Hz, 8 H), 6.27 (s, 8 H), 1.29 (s, 36 H). 13C NMR(600 MHz, CDCl3, d): 149.92, 145.93, 134.96, 132.37, 130.58, 128.67,123.22, 115.03, 110.98, 84.10, 64.85, 28.05.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Tetrakis(4-bromophenyl)methane, and friends who are interested can also refer to it.

Reference:
Article; Yang, Yanqin; Zhang, Qiang; Zheng, Jifu; Zhang, Suobo; Polymer; vol. 54; 13; (2013); p. 3254 – 3260;,
Bromide – Wikipedia,
bromide – Wiktionary