Category: 103977-79-3

Application of 103977-79-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 103977-79-3 as follows.

A solution of 3-bromo-2, 4-difluorophenylamine (from Example 2, step b) (5. 2 g, 25 mmol) and 5-fluoro-2- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl) benzonitrile (7.10 g, 28.8 mmol) in tetrahydrofuran (95 ml) and water (5 ml) was treated with potassium fluoride (4.8 g, 82.5 mmol) and this mixture was degassed with nitrogen for 10 min before adding tris (dibenzylideneacetone) dipalladium (0) (460 mg, 0. 5 mmol) and tri-tert-butylphosphine (2.5 ml of a 0.2 M solution in 1,4-dioxane, 0. 5 mmol). The reaction was then heated at 50C for 2 h then cooled to ambient temperature. The mixture was poured into ice-cold 0.5 N sodium hydroxide (750 ml), stirred for 10 min and the solid collected by filtration. This was triturated with water and dried to afford 3′-amino- 4, 2′, 6′-triffuorobiphenyl-2-carbonitrile as a grey powder (6.6 g), which was used without further purification: 1H NMR (360 MHz, Cd13) 8 3.74 (2H, br s), 6.79-6. 89 (2H, m), 7.36-7. 42 (1H, m), 7.45-7. 51 (2H, m).

According to the analysis of related databases, 103977-79-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2003/93272; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 103977-79-3, The chemical industry reduces the impact on the environment during synthesis 103977-79-3, name is 3-Bromo-2,4-difluoroaniline, I believe this compound will play a more active role in future production and life.

C. Ethyl 7-bromo-6,8-difluoro-4-hydroxyquinoline-3-carboxylate A stirred mixture of 26 g of 3-amino-2,6-difluorobromobenzene and 27 g of diethyl ethoxymethylenemalonate was heated at 150 C. for 1 hour. After cooling, 100 ml of Dowtherm “A” (commercially available high boiling inert solvent mixture of diphenylether and dibenzofuran) was added and the mixture was heated under nitrogen at 260 C. for 1.5 hour. The mixture was cooled to room temperature and 200 ml of hexanes was added. The resulting precipitate was collected by filtration, washed with hexanes and dried to give a cream solid, m.p. 285 C., yield 78% (32.32 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-2,4-difluoroaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pfizer Inc.; US4623650; (1986); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 103977-79-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 103977-79-3 as follows.

A mixture of 106 2,2-dimethyl-1,3-dioxane-4,6-dione (7.62 g, 52.88 mmol) in 107 trimethoxymethane (26.3 mL, 240.38 mmol) was heated at 85 C. and stirred for 1.5 h. 498 3-Bromo-2,4-difluoroaniline (10 g, 48.08 mmol) in 33 ethanol (42.4 mL) was added and the reaction mixture was stirred at 85 C. for 3 h. The mixture was cooled with the resulting solid was filtered and washed with IPA (2¡Á50 mL) and diethyl ether (4¡Á50 mL). The solid was dried under vacuum overnight to afford 499 5-[(3-bromo-2,4-difluoroanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione (14.62 g, 84%) as a beige solid; 1H NMR (400 MHz, DMSO, 30 C.) 1.69 (6H, s), 7.33-7.43 (1H, m), 7.86-7.97 (1H, m), 8.56-8.64 (1H, m), 11.24 (1H, s); m/z: ES+ [M+H]+ 362.0.

According to the analysis of related databases, 103977-79-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

103977-79-3, name is 3-Bromo-2,4-difluoroaniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H4BrF2N

To a mixture of 4,4,5,5,4′,4′,5′,5′-octamethyl-[2,2′]bi[[1,3,2]dioxaborolanyl] (1.831 g, 7.21 mmol), potassium acetate (1.415 g, 14.42 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complexed with dichloromethane (1:1) (0.785 g, 0.962 mmol) under nitrogen was added a solution of 3-bromo-2,4-difluoroaniline (1.0 g, 4.81 mmol) in 1,4-dioxane (20 mL). The mixture was stirred at 100 C. overnight. After cooling to room temperature, the mixture was diluted with DCM and filtered through Celite. The filtrated was concentrated in vacuo. The residue was purified by Biotage Isolera (740 mg, 60%). LCMS calculated for C12H17BF2NO2 (M+H)+ m/z=256.1; found 256.1.

The synthetic route of 103977-79-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Incyte Corporation; Vechorkin, Oleg; Pan, Jun; Liu, Kai; Sokolsky, Alexander; Wang, Anlai; Ye, Hai Fen; Ye, Qinda; Yao, Wenqing; (167 pag.)US2018/72720; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary