Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1037138-94-5, name is 2-Bromo-4-fluoro-N-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Bromo-4-fluoro-N-methylaniline
A mixture of 2-bromo-4-fluoro-N-methylaniline (2 g, 9.8 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi-1,3,2-dioxaborolane (2.99 g, 11.76 mmol), 1,1′-bis(diphenylphosphino)ferrocenedichloro palladium(II) dichloromethane complex (359 mg, 0.490 mmol) and potassium acetate (2.89 g, 29.4 mmol) in 1,2-dimethoxyethane (60 mL) was purged with nitrogen and heated at 80 C. overnight. After cooling, heptane (100 mL) was added and the mixture was filtered through diatomaceous earth and washed with 3:1 heptane/ethyl acetate. The filtrate was concentrated and the residue was purified by flash chromatography on silica gel (Teledyne CombiFlash Rf, 5-30% ethyl acetate in heptane) to provide the title compound, which was contaminated by corresponding boronic acid. MS (DCI/NH3) m/z 252 (M+H)+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1037138-94-5.
Reference:
Patent; ABBVIE INC.; Frey, Robin; Gong, Jianchun; JI, Zhiqin; Lai, Chunqiu; Penning, Thomas; Song, Xiaohong; Souers, Andrew; Tong, Yunsong; Zhu, Gui-Dong; US2015/218165; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary