Category: 103275-21-4

Reference of 103275-21-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 103275-21-4, name is 3-Bromo-4-(tert-butyl)aniline, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3-bromo-4- tert-butyl-phenylamine (5.00 g, 21.92 mmol) in 80 mL of DCM and 25 mL of methanol was added calcium carbonate (4.39 g, 43.83 mmol), followed by iodinating reagent (8.55 g, 21.92 mmol). The reaction was stirred for 3 h at room temperature, quenched with water 100 mL, and the product extracted into ethyl acetate (100 mL). The organic layer was washed with brine (75 mL), dried over magnesium sulfate and concentrated. Silica gel chromatography eluting with 25% ethyl acetate/hexane gave the product as an oil (4.50 g, 12.7 mmol, 58%) : 1H NMR (400 MHz, CDC13) 6 7. 61 (s, 1 H), 6.99 (t, J = 0.9 Hz, 1H), 3 : 96 (s, 2H), 1.44 (s, 9H); MS (ESI) 356.3.

The chemical industry reduces the impact on the environment during synthesis 3-Bromo-4-(tert-butyl)aniline. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2005/70407; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 103275-21-4, A common heterocyclic compound, 103275-21-4, name is 3-Bromo-4-(tert-butyl)aniline, molecular formula is C10H14BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-bromo-4- tert-butyl-phenylamine (5.00 g, 21.92 mmol) in 80 mL of DCM and 25 mL of methanol was added calcium carbonate (4.39 g, 43.83 mmol), followed by iodinating reagent (8. 55 g, 21.92 mmol). The reaction was stirred for 3 h at room temperature, quenched with water 100 mL, and the product extracted into ethyl acetate (100 mL). The organic layer was washed with brine (75 mL), dried over magnesium sulfate and concentrated. Silica gel chromatography eluting with 25% ethyl acetate/hexane gave the product as an oil (4.50 g, 12.7 mmol, 58%) : H NMR (400 MHz, CDCI3) ; 5 7. 61 (s, 1H), 6.99 (t, J = 0.9 Hz, 1H), 3.96 (s, 2H), 1.44 (s, 9H); MS (ESI) 356.3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2005/87215; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary