Category: 1013031-65-6

Zheng, Hong-Xing; Shan, Xiang-Huan; Qu, Jian-Ping; Kang, Yan-Biao published the artcile< Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans>, Electric Literature of 1013031-65-6, the main research area is haloaralkyl ether aldehyde tandem intermol radical addition cyclization; benzofuran preparation.

An intermol. addition of carbon radicals enabled by a cascade radical coupling strategy is developed. It includes an intermol. alkyl radical addition to a carbonyl group followed by an intramol. alkoxy radical addition to haloarenes and produces substituted benzofurans in high yields. The radical nature of this reaction is explored by radical trapping experiments and EPR anal. The mechanism is investigated by KIE experiments and control experiments This method could provide rapid and practical access to the key intermediate of TAM-16, a safe and potent antibacterial agent for treating tuberculosis, and, therefore, is of great importance for organic synthesis and the pharmaceutical industry.

Organic Letters published new progress about Aldehydes Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 1013031-65-6 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6Br2O, Electric Literature of 1013031-65-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ema, Tadashi; Tanida, Daisuke; Matsukawa, Tatsuya; Sakai, Takashi published the artcile< Biomimetic trifunctional organocatalyst showing a great acceleration for the transesterification between vinyl ester and alcohol>, Category: bromides-buliding-blocks, the main research area is biomimetic trifunctional organocatalyst transesterification vinyl ester alc.

Trifunctional organocatalysts (I) 1a (X = S) and 1b (X = O) mimicking the active site of serine hydrolases showed high catalytic activity with up to a 3700000-fold acceleration for the acyl-transfer reactions from vinyl trifluoroacetate to alc.

Chemical Communications (Cambridge, United Kingdom) published new progress about Enzyme mimics Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 1013031-65-6 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6Br2O, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Giardina, Sarah F.; Werner, Douglas S.; Pingle, Maneesh; Feinberg, Philip B.; Foreman, Kenneth W.; Bergstrom, Donald E.; Arnold, Lee D.; Barany, Francis published the artcile< Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase>, SDS of cas: 1013031-65-6, the main research area is self assembling dimeric inhibitor human beta tryptase preparation; heterodimeric tryptase inhibitor mol modeling pharmacokinetics.

β-Tryptase, a homotetrameric serine protease, has four identical active sites facing a central pore, presenting an optimized setting for the rational design of bivalent inhibitors that bridge two adjacent sites. Using diol, hydroxymethyl phenols or benzoyl Me hydroxamates, and boronic acid chemistries to reversibly join two [3-(1-acylpiperidin-4-yl)phenyl]methanamine core ligands, we have successfully produced a series of self-assembling heterodimeric inhibitors. These heterodimeric tryptase inhibitors demonstrate superior activity compared to monomeric modes of inhibition. X-ray crystallog. validated the dimeric mechanism of inhibition, and compounds demonstrated high selectivity against related proteases, good target engagement, and tryptase inhibition in HMC1 xenograft models. Screening 3872 possible combinations from 44 boronic acid and 88 diol derivatives revealed several combinations that produced nanomolar inhibition, and seven unique pairs produced greater than 100-fold improvement in potency over monomeric inhibition. These heterodimeric tryptase inhibitors demonstrate the power of target-driven combinatorial chem. to deliver bivalent drugs in a small mol. form.

Journal of Medicinal Chemistry published new progress about Homo sapiens. 1013031-65-6 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6Br2O, SDS of cas: 1013031-65-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Scott, Colleen N.; Wilcox, Craig S. published the artcile< A Mild Synthesis of Unsymmetrical Bisalkoxysilanes through Catalyzed Alcoholysis of Hydridosilanes Containing C-C Multiple Bonds and Aryl Halides>, Computed Properties of 1013031-65-6, the main research area is silane bis alkoxy preparation; alcoholysis hydrido silane manganese catalyst alkenol aryl bromide.

The synthesis of unsym. bisalkoxysilanes containing unsaturated C-C bonds and alkyl and aryl bromides has been developed. This method is a modification of our previously reported two-step procedure that utilizes readily available catalysts (rhodium acetate dimer and manganese pentacarbonyl bromide) under mild neutral aprotic conditions. Good to moderate yields of the products were obtained in a short period. In this two-step synthesis, unsym. bisalkoxysilanes with groups that can be further functionalized can be prepared effectively without the need to isolate the intermediates.

Journal of Organic Chemistry published new progress about Alcoholysis. 1013031-65-6 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6Br2O, Computed Properties of 1013031-65-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cao, Qingxiang; Luo, Jie; Zhao, Xiaodan published the artcile< Chiral Sulfide Catalysis for Desymmetrizing Enantioselective Chlorination>, Recommanded Product: (2,6-Dibromophenyl)methanol, the main research area is chiral sulfide catalyzed desymmetrizing enantioselective chlorination aryl olefin; tetralin enantioselective diastereoselective synthesis; tricyclic hexahydrophenalene enantioselective diastereoselective synthesis; spiro nitrogen heterocycle synthesis; Lewis base catalysis; chlorination; cyclizations; olefins; synthetic methods.

An unprecedented chiral sulfide catalyzed desymmetrizing enantioselective chlorination is disclosed. Various aryl-tethered diolefins and diaryl-tethered olefins afforded tetralins and tricyclic hexahydrophenalene derivatives, resp., bearing multiple stereogenic centers in high yields with excellent enantio- and diastereoselectivities [e.g., I → II (91%, 93% ee, 31:1 d.r.) in presence of sulfide III, DCDMH as Cl+ reagent and Tf2NH as acid in CH2Cl2]. In contrast, the tertiary amine catalyst (DHQD)2PHAL led to a diastereomeric product. The products could be transformed into a variety of compounds, such as spiro-N-heterocycles.

Angewandte Chemie, International Edition published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aryl-tethered diolefins). 1013031-65-6 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6Br2O, Recommanded Product: (2,6-Dibromophenyl)methanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary