Category: 10016-52-1

Application of 10016-52-1, These common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 1 L reaction flask was added toluene solvent (450 ml), 2,8-dibromodibenzofuran (11.74 g, 36 mmol),Intermediate I-11 (32.62 g, 90 mmol), Pd2 (dba) 3 (990 mg, 1.08 mmol),BINAP (1.65 g, 16.5 mmol) and sodium tert-butoxide (9.9 g, 100.8 mmol),Dissolved by stirring, and refluxed under nitrogen for 24 hours.After completion of the reaction, the reaction solution was washed with dichloromethane and distilled water and then evaporated.The organic layer was dried over anhydrous magnesium sulfate and filtered and evaporated.Separation and purification by column chromatography using cyclohexane:ethyl acetate=10:1 as eluent.Finally, solid compound 11 (24.00 g, yield 75%) was obtained, and the solid purity was determined to be 99.5% by HPLC.

Statistics shows that 2,8-Dibromodibenzo[b,d]furan is playing an increasingly important role. we look forward to future research findings about 10016-52-1.

Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhao Qian; Liu Hui; Han Chunxue; (55 pag.)CN110407829; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 10016-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

30.0 g (92.03 mmol) of 2,8-dibromodibenzo [b, d] furan in a 1 L reactor, Add 19.1 g (138.05 mmol) of anhydrous potassium carbonate, add 300 mL of ethylene glycol under a stream of nitrogen, raise the temperature to 120 degrees, and stir for 48 hours.After completion of the reaction, the mixture was extracted with ethyl acetate, aqueous sodium bicarbonate solution, distilled water, treated with anhydrous magnesium sulfate, filtered, and purified by silica gel chromatography.9.8 g (yield 41%) of the target compound [67-1] as a off-white solid was prepared.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,8-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Teuri L Co., Ltd.; Kang Ji-seung; Moon Bong-seok; Jin Seong-min; Hong Won-gi; Ha Min-su; Lee Gyu-seong; Jin Sang-jun; Park No-gil; Lee Hyeon-u; Byun U-geun; (50 pag.)KR2019/139404; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2,8-Dibromodibenzo[b,d]furan

2.75 g (10 mmol) of 4-phenylaminodibenzothiophene, 1.63 g (5.0 mmol) of 2,8-dibromodibenzofuran, 2.5 g (26 mmol) of sodium t-butoxide in a 50 ml four-necked flask,50 ml of dehydrated toluene was added and nitrogen bubbling was performed for 1 hour. Then, 3460 mg (0.5 mmol) of Pd2 (dba),290 mg (1.0 mmol) of tri-t-butylphosphonium tetrafluoroborate (t-Bu3PH + BF4-) was added, and the mixture was heated under reflux for 53 hours while stirring under a nitrogen stream. The formation of the desired product was confirmed by TLC and MS. The reaction solution was cooled to room temperature, and the organic layer was extracted with toluene, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to obtain a brown viscous product. The obtained viscous material was dissolved in 10 ml of toluene and packed in a column. The resultant was directly purified by silica gel column chromatography (developing solvent: toluene / hexane = 1/4) to obtain the desired product.Yield 1.92g, 54%

The synthetic route of 10016-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; National University Corporation Yamagata University; Sasabe, Hisahiro; Kido, Junji; Kamata, Takahiro; (21 pag.)JP2019/26556; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 10016-52-1, The chemical industry reduces the impact on the environment during synthesis 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.

The second scheme: to 250 ml three-mouth bottle adding 2.36g (3.8 × 10-3Mol) precursor 3 (through the implementation of example three preparation) and 0.5g (1.53 × 10-3Mol) 2, 8 – dibromodiphenyl benzofuran, adding 100g toluene. Opening stirring, system for the picture and the turbid, N2Replacement system 10min. In the system by adding 0.37g (3.84 × 10-3Mol) tertiary butyl alcohol sodium, 0.045g (6.14 × 10-5Mol) Pd (dppf) Cl2And 0.025g (1.24 × 10-4Mol) tri-butyl phosphine, 110 C reaction 20 hours. The said technological, cooling to 20 – 25 C, the reaction liquid filtration, filtrate directly filtering of the silica gel column, eluting with toluene, the solvent under reduced pressure, the crude product shall be light brown red foam. In the above-mentioned crude product is added n-hexane and toluene recrystallization (mass ratio of 4:1), gain the light yellow powdery product 1.7g, yield: 65%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,8-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CECEP Wanrun Co., Ltd.; Ren Huicai; Pang Maoyin; Yang Fushan; Tian Shaozhen; Shi Rujin; Hu Baohua; (14 pag.)CN105153085; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C12H6Br2O

2,8-Dicyanodibenzofuran 11. A mixture of 2,8-dibromodibenzofuran (10, 10.93 g, 33.53 mmol) and copper(I) cyanide (8.91 g, 102 mmol) in DMF (80 mL) was refluxed under N2 for 9 h. The reaction mixture was poured into ice-water (300 mL). The precipitated solid was filtered off and stirred overnight in a solution of ethylenediamine (50 mL) in water (300 mL). The solid was filtered off, washed with water, then stirred in 10% sodium cyanide solution (100 mL) overnight. The solid was further purified by suspension in hot ethanol (100 mL) to give a white powder (6.97 g, 95.2%): mp 298-300 C. (dec.) (Lit. [37] 299 C.); HPLC method 1 tR=24.07 min (97.3 area %); 1H NMR (400 MHz, DMSO-d6) delta 8.05 (d, J=8.7 Hz, 2 H), 8.12 (dd, J1=8.7 Hz, J2=1.4 Hz, 2 H), 8.85 (d, J=1.4 Hz, 2 H). Anal. (C14H6N2O.0.4H2O) C, H, N. 4,4′-Dibromo-2,2′-dinitrobiphenyl 14 [Moffatt, J. S. 3:6-Diamidinodibenzofuran. J. Chem. Soc. 1951, 625-62]. A suspension of 2,5-dibromonitrobenzene (13, 50.0 g, 178 mmol) and copper powder (100 mesh, 25.0 g, 391 mmol) in DMF (300 mL) was stirred at 137 C. (oil bath) under N2 for 2 h. The mixture was poured into toluene (1000 mL) and stirred for 4 h. Then the mixture was passed through Celite 545. The filtrate was collected and washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated, and the residue was recrystallized from ethanol (650 mL) to give a pale yellow solid (31.33 g, 87.57%): m.p. 143-146 C. (reported 150 C. [Shaw, F. R.; J. Chem. Soc. 1932, 285-297] and 146-148 C. [Yamato, T.; et al., J. Org. Chem. 1991, 56, 6248-6250]); HPLC method 3 tR=18.70 min (97.2%); NMR (300 MHz, CDCl3) delta 8.40 (d, J=2.0 Hz, 2 H), 7.85 (dd, J1=8.2 Hz, J2=2.0 Hz, 2 H), 7.18 (d, J=8.2 Hz, 2 H).

The synthetic route of 10016-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The University of North Carolina at Chapel Hill; US6172104; (2001); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2,8-Dibromodibenzo[b,d]furan

250mL 2 necked flask equipped with a 10-phenyl-2 ‘- (4,4,5,5-tetra-methyl -1,3,2-dioxa-beam as is -2 yl) -10H- spiro [acridine -9,9’- fluorene] (3g, 5.62mmol), 2,8- di-bromo-modify-benzo [b, d] furan (2,8-dibromodibenzo [b, d] furan) (0.95 g, 2.25 mmol) , tetrakis (triphenylphosphine) palladium (0) (0.13g, 0.112 mmol), potassium carbonate (1.5g, 11.2mmol), tetrahydrofuran: water (3: 1) is dissolved in the mixture was stirred under reflux.After 12 hours After cooling to room temperature, extracted with dichloromethane, and then after drying the water with magnesium sulfate to remove the solvent.Hexane: ethyl acetate (10: 0.5) and the column with the solvent, to filter the resulting solid was precipitated with petroleum ether to give a white solid Compound B 1.5g (68% yield)

The synthetic route of 10016-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG DISPLAY CO., LTD.; Bae, Sook Young; Song, In Bum; Yun, Gyung Jin; Lee, Sang Ho; Noh, Hyo Jin; Yun, Dae Wei; Haw, Hay Ryong; Kim, Chun Gi; (17 pag.)KR2015/65385; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2,8-Dibromodibenzo[b,d]furan

1b) 2,8-Bis-((E)-styryl)-dibenzofuran Tetrethylamine hydroxide (13.6 g, 18.4 mmol), tetrakis(triphenylphosphine)palladium(0) (142 mg) and trans-2-phenylvinylboronic acid (2.3 g, 15.3 mmol) are added to a solution of the product from example 1a) (2.00 g, 6.14 mmol) in N,N’-Dimethylacetamide (DMA) (30 ml). The mixture is then stirred at 110 C. for 24 hours. The reaction mixture is cooled to room temperature and poured into H2O. A gray crude product is obtained after filtration and washing with n-hexane. The crude product is purified by silicagel column chromatography with CH2Cl2, which result in a white solid (71% yield, mp.: 226 C.). 1H-NMR (CDCl3, ppm): 7.26-7.30 (m, 6H), 7.39 (t, 4H), 7.54-7.58 (m, 6H), 7.65 (dd, 2H), 8.12 (d, 2H)

The synthetic route of 2,8-Dibromodibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tanabe, Junichi; Oka, Hidetaka; Yamamoto, Hiroshi; US2009/131673; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2,8-Dibromodibenzo[b,d]furan

To a 250 ml three-mouth bottle adding 5.04g (0.022 muM) precursor 1 (through the implementation of example one preparation) and 3.26g (0.01 muM) 2, 8 – dibromodiphenyl benzofuran, the mixture thus obtained is VI, VI is added to the mixture in the 40g toluene. Opening stirring, system for the picture and the turbid, N2Replacement system 10min. In the system by adding 2.8g (0.025 muM) tert-butanolate, 0.18g (2 × 10-4Mol) Pd2(Dba)3And 0.12g (4 × 10-4Mol) tri-butyl phosphine four fluoroborates, 80 C reaction 8 hours. The said technological, cooling to 20 – 25 C, the reaction liquid filtration, filtrate directly filtering of the silica gel column, eluting with toluene, the solvent under reduced pressure, to be brownish red color oil of 6.5g. In the above-mentioned crude product in adding toluene and hexane recrystallization (mass ratio of 2:1), vacuum drying oven drying 3h, gain the light yellow powder 2.5g, yield: 40.2%.

The synthetic route of 2,8-Dibromodibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CECEP Wanrun Co., Ltd.; Ren Huicai; Pang Maoyin; Yang Fushan; Tian Shaozhen; Shi Rujin; Hu Baohua; (14 pag.)CN105153085; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 10016-52-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, This compound has unique chemical properties. The synthetic route is as follows.

Under a stream of nitrogen, 0.46 g (1.4 mmol) of 2,8-dibromodibenzofuran (manufactured by Sigma-Aldrich Co. LLC.) and 0.90 g (2.8 mmol) of Exemplified Compound 18-1 were added to 15 ml of DMSO and 0.89 g (4.2 mmol) of potassium phosphate and stirred for 10 minutes. To the resultant, 53 mg (0.28 mmol) of CuI and 6-methyl picolinic acid (0.56 mmol) were added and heated at 125 C. for 7 hours. Under cooling with water, 5 ml of water was added thereto and stirred for 1 hour. The precipitated crude product was filtered, further subjected to the column purification, and then recrystallized with o-dichlorobenzene/acetonitrile so as to obtain 0.80 g (yield of 71%) of Exemplified Compound 18.

The chemical industry reduces the impact on the environment during synthesis 2,8-Dibromodibenzo[b,d]furan. I believe this compound will play a more active role in future production and life.

Reference:
Patent; KONICA MINOLTA, INC.; Okubo, Yasushi; Itoh, Hiroaki; Wachi, Ayako; Ishidai, Hiroshi; (69 pag.)US9941422; (2018); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 10016-52-1,Some common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a nitrogen environment 9H-carbazole(100 g, 598 mmol) was dissolved in 2,000 mL of toluene, where the 2,8-dibromodibenzofuran(292 g, 897 mmol), tris(diphenoquinone alkylpiperidinyl) dipalladium (o) (5.48 g, 5.98 mmol), tris-tertbutylphosphine(6.05 g, 29.9 mmol) and sodium tert-butoxide(69.0 g, 718 mmol) sequentially into heating by and it refluxed during100 C in 32 hours . After the reaction was completed, the reaction solution into water and extracted with dichloromethane (DCM) and then water was removed with anhydrous MgSO4, filter and was concentrated under reducedpressure. Thus separated and purified the resulting residue was purified by flash column chromatography compounds to obtain a I-7(98.6 g, 40%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,8-Dibromodibenzo[b,d]furan, its application will become more common.

Reference:
Patent; Cheil Industries Co., Ltd; Lee, Han Ir; Yu, Uhn Sun; Kang, Dong Min; Kang, Uii Soo; Yang, Yong Tak; Oh, Jae Jin; Yu, Dong Gyu; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; Hong, Jin Suk; (59 pag.)KR2015/6758; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary