The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Evaluation of a series of bicyclic CXCR2 antagonists》. Authors are Walters, Iain; Austin, Caroline; Austin, Rupert; Bonnert, Roger; Cage, Peter; Christie, Mark; Ebden, Mark; Gardiner, Stuart; Grahames, Caroline; Hill, Steven; Hunt, Fraser; Jewell, Robert; Lewis, Shirley; Martin, Iain; Nicholls, David; Robinson, David.The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).Formula: C7H12O3. Through the article, more information about this compound (cas:1001-26-9) is conveyed.
The CXCR2 SAR of a series of bicyclic antagonists such as the 2-aminothiazolo[4,5-d]pyrimidine 3b was investigated by systematic variation of the fused pyrimidine-based heterocyclic cores. Replacement of the aminothiazole ring with a 2-thiazolone alternative led to a series of thiazolo[4,5-d]pyrimidine-2(3H)-one antagonists with markedly improved biol. and pharmacokinetic properties, which are suitable pharmacol. tools to probe the in vivo effects of CXCR2 antagonism combined with the associated CCR2 activity.
If you want to learn more about this compound(Ethyl 3-Ethoxy-2-Propenoate)Formula: C7H12O3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1001-26-9).
Reference:
Bromide – Wikipedia,
bromide – Wiktionary