Category: 1000994-95-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1000994-95-5, name is 1-Bromo-4-(1,1-difluoroethyl)benzene, A new synthetic method of this compound is introduced below., name: 1-Bromo-4-(1,1-difluoroethyl)benzene

Into a 1000-ml glass reaction vessel equipped with a stirring apparatus were placed 14.85 g (67.2 mmol) of Compound (4-1), 14.09 g (20.2 mmol) of dichlorobis(triph42enylphosphine)palladium(II), 32.6 g (87.4 mmol) of 2-(tributyltin)thiophene, and 450 ml of toluene. The mixture was reacted at an internal temperature of about 100 C. for 2 hours. Afier the completion of the reaction, the reaction solu5 tion was filtered with Celite, and then the solvent was concentrated. And then, inorganic substances were removed by filtration, and the filtrate was concentrated. The concentrate was purified by silica gel column chromatography (normal phase silica gel:potassium carbonate=90: 10 (weight ratio),hexane: 100 vol %). Subsequently, the resultant material was purified again by normal phase silica gel column chromatography (hexane: 100 vol %), to provide 9.8 g of Compound (4-2) in the form of a white solid.The properties of Compound (4-2) were as follows.?H-NMR (400 MHz, CDC13, oe (ppm)); 1.94 (3H, t, J=18.1 Hz), 7.09-7.26 (1H, m), 7.31-7.36 (2H, m), 7.51 (2H, d, J=8.6 Hz), 7.66 (2H, d, J=6.8 Hz)EI-MS; 224 (M+)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; UBE INDUSTRIES, LTD.; Tokito, Shizuo; Kumaki, Daisuke; Shima, Hidetaka; Oda, Hiroyuki; Tanaka, Yasuhiro; Kakita, Kazuaki; Machida, Toshikazu; Yoneda, Yasuhiro; Omata, Youji; Shimano, Tetsuro; (55 pag.)US9290516; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1000994-95-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1000994-95-5, name is 1-Bromo-4-(1,1-difluoroethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.

Into a 1000-ml glass reaction vessel equipped with a stirring apparatus were placed 14.85 g (67.2 mmol) of Compound (4-1), 14.09 g (20.2 mmol) of dichlorobis(triphenylphosphine)palladium(II), 32.6 g (87.4 mmol) of 2-(tributyltin)thiophene, and 450 ml of toluene. The mixture was reacted at an internal temperature of about 100C for 2 hours. After the completion of the reaction, the reaction solution was filtered with Celite, and then the solvent was concentrated. And then, inorganic substances were removed by filtration, and the filtrate was concentrated. The concentrate was purified by silica gel column chromatography (normal phase silica gel: potassium carbonate = 90 : 10 (weight ratio), hexane: 100 vol%). Subsequently, the resultant material was purified again by normal phase silica gel column chromatography (hexane: 100 vol%), to provide 9.8 g of Compound (4-2) in the form of a white solid. [0137] The properties of Compound (4-2) were as follows. 1H-NMR (400MHz, CDCl3, 8 (ppm)); 1.94 (3H, t, J=18.1Hz), 7.09-7.26 (1H, m), 7.31-7.36 (2H, m), 7.51 (2H, d, J=8.6Hz), 7.66 (2H, d, J=6.8Hz) EI-MS; 224 (M+)

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-4-(1,1-difluoroethyl)benzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; UBE Industries, Ltd.; TOKITO, Shizuo; KUMAKI, Daisuke; SHIMA, Hidetaka; ODA, Hiroyuki; TANAKA, Yasuhiro; KAKITA, Kazuaki; MACHIDA, Toshikazu; YONEDA, Yasuhiro; OMATA, Youji; SHIMANO, Tetsuro; EP2829542; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 1000994-95-5, The chemical industry reduces the impact on the environment during synthesis 1000994-95-5, name is 1-Bromo-4-(1,1-difluoroethyl)benzene, I believe this compound will play a more active role in future production and life.

In a 40 ml vial, bromo derivative (250 mg, 1.13 mmol, 1.0 eq.), bispinacolotodiboron (288.6 mg, 1.13 mmol, 1.0 eq.), Pd(dppf)CI2 (92.7 mg, 0.114 mmol, 0.1 eq.) and potassium acetate (354.5 mg, 3.41 mmol, 3.0 eq.) were mixed in dioxane (10 ml) and heated to 80 C for 8 hours. LCMS indicated that the product was formed in major amount. . The crude reaction was purified in the presence of silica (10-15 gm) and purified using hexanes: ethyl acetate (0-100%) to yield desired boron ester. The product was characterized by reverse phase HPLC using method 4. (ES, m/z) [M + H+] 269.0. Retention time = 1.60 mins.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(1,1-difluoroethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; IRM LLC; NOVARTIS AG; CHATTERJEE, Arnab Kumar; NAGLE, Advait Suresh; PARASELLI, Prasuna; LEONG, Seh Yong; ROLAND, Jason Thomas; MISHRA, Pranab Kumar; YEUNG, Bryan KS; ZOU, Bin; WO2014/78813; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 1000994-95-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1000994-95-5, name is 1-Bromo-4-(1,1-difluoroethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.

Step 4:To a mixture of compound 5b4 (210 mg, 0.95 mmol) in DMF (6.0 mL) is added bis(pinacolato)diboron (265 mg, 1.045 mmol) and KOAc (205 mg, 2.09 mmol). Argon is passed through the mixture for 5 minutes and PdCI2(dppf)-CH2CI2 (77.6 mg, 0.095 mmol) is added. Argon is passed through the mixture for 3 minutes further and the mixture is allowed to react at 80C overnight. The mixture is extracted with EtOAc and the extract is washed with brine, dried (MgSO4), filtered through Celite and concentrated to provide boronic acid 5b5.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-4-(1,1-difluoroethyl)benzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH & CO KG; WO2007/131350; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 1000994-95-5, The chemical industry reduces the impact on the environment during synthesis 1000994-95-5, name is 1-Bromo-4-(1,1-difluoroethyl)benzene, I believe this compound will play a more active role in future production and life.

Reference Example 17-1 4-(1,1-Difluoroethyl)benzaldehyde To a solution of 1-bromo-4-(1,1-difluoroethyl)benzene (1.00 g) in tetrahydrofuran (10.0 mL), n-butyl lithium (2.69 mol/L, solution in n-hexane, 1.68 mL) was added at -80C and the mixture was stirred at that temperature for 5 minutes. Subsequently, N,N-dimethylformamide (0.522 mL) was added at -80C and after stirring the mixture at that temperature for 20 minutes, 2 mol/L hydrochloric acid (2.50 mL) was added. After bringing the reaction mixture to room temperature, two extractions were conducted with ethyl acetate and the combined organic layers were washed with water. After drying over anhydrous magnesium sulfate and the desiccant was removed by filtration; the filtrate was then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate = 100:0-90:10) to give the titled compound as a colorless oil (510 mg). 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 1.95 (t, J=18.2 Hz, 3 H) 7.64 – 7.73 (m, 2 H) 7.92 – 7.98 (m, 2 H) 10.07 (s, 1 H). MS EI posi: 170[M]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(1,1-difluoroethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; TAKAYAMA, Tetsuo; SHIBATA, Tsuyoshi; SHIOZAWA, Fumiyasu; KAWABE, Kenichi; SHIMIZU, Yuki; HAMADA, Makoto; HIRATATE, Akira; TAKAHASHI, Masato; USHIYAMA, Fumihito; OI, Takahiro; SHIRASAKI, Yoshihisa; MATSUDA, Daisuke; KOIZUMI, Chie; KATO, Sota; EP2881384; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

1000994-95-5, name is 1-Bromo-4-(1,1-difluoroethyl)benzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1000994-95-5

Nitrogen,Titration in the following -60 1.6M n-butyllithium in hexane (0.4 mL)in1-Bromo-4- (1,1-difluoroethyl) benzene(0.17 g)Of tetrahydrofuran (0.61 g)The solution was stirred for an additional 1 hour and titrated for 4 minutes5-cyclopropyl-6-methoxymethylpyridinecarbonitrile(0.10 g)In tetrahydrofuran (0.30 g).After stirring for 2 hours and 2 minutes, the temperature was further raised to room temperature.After adding 5% aqueous hydrochloric acid solution (0.93 g) and stirring,Water and ethyl acetate were added,The mixture was separated into a mixture of an organic layer and an aqueous layer.Ethyl acetate (4 mL) was added to the resulting aqueous layer,Mixed and separated into an organic layer and an aqueous layer.Mixing the organic layers of both,The mixture was separated by adding 5% aqueous sodium hydrogencarbonate solution, and the organic layer and the aqueous layer were mixed.Ethyl acetate (2 mL) was added to the resulting aqueous layer,Mixed and separated into an organic layer and an aqueous layer.The organic layers were mixed, and the organic layer and the aqueous layer were mixed by adding water. Ethyl acetate (2 mL) was added to the obtained aqueous layer, mixed, and separated into an organic layer and an aqueous layer. The organic layers were mixed, dried by addition of sodium sulfate, and after the desiccant was filtered off, the solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane / ethyl acetate = 49/1, v / v)To obtain the title compound (0.14 g, yield 75.1%) as a pale yellow oily substance.

The synthetic route of 1000994-95-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; YOSHINO, HIRONOBU; UMEDA, YASUHIRO; TAKEOKA, JUN; NAGAYA, AKIHIRO; SUGAWARA, YUDAI; YOSHINO, MADOKA; (54 pag.)TW2016/5826; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary