On November 5, 2021, Tak, Raj K.; Noda, Hidetoshi; Shibasaki, Masakatsu published an article.Category: bromides-buliding-blocks The title of the article was Ligand-enabled, copper-catalyzed electrophilic amination for the asymmetric synthesis of β-amino acids. And the article contained the following:
Catalytic asym. nitrene transfer has emerged as a reliable method for the synthesis of nitrogen-containing chiral compounds Herein, we report the copper-catalyzed intramol. asym. electrophilic amination of aromatic rings. The reactive intermediate is a copper-alkyl nitrene generated from isoxazolidin-5-ones. Copper catalysis promotes three classes of asym. transformations, namely, asym. desymmetrization, parallel kinetic resolution, and kinetic resolution, expanding the repertoire of alkyl nitrene transfer and providing various cyclic and linear β-amino acids in their enantioenriched forms. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Category: bromides-buliding-blocks
The Article related to amino acid beta cyclic linear enantioselective synthesis solvent effect, electrophilic amination copper catalyst isoxazolidinone nitrene, asym desymmetrization kinetic resolution nitrene transfer and other aspects.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary