Electric Literature of 4549-33-1,Some common heterocyclic compound, 4549-33-1, name is 1,9-Dibromononane, molecular formula is C9H18Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Compound 2a or 2b (2 mmol) and KOH (0.34 g, 6 mmol) weredissolved in acetonitrile. The solution was stirred for 1 h under argonat room temperature. Then, different dibromoalkanes(4 mmol) were added to the mixture. After stirring for 48 h, themixture was filtered and evaporated under reduced pressure. Theresidue was chromatographed on silica gel, with petroleumether/ethyl acetate, 10:1, plus 10 mL triethylamine per 1000 mLas the eluent to afford the compounds.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,9-Dibromononane, its application will become more common.
Reference:
Article; Sun, Yang; Chen, Jianwen; Chen, Xuemin; Huang, Ling; Li, Xingshu; Bioorganic and Medicinal Chemistry; vol. 21; 23; (2013); p. 7406 – 7417;,
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bromide – Wiktionary