Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Name: 4-Bromobenzene-1,2-diamine.
Yadav, Anamika;Yadav, Anubhav;Tripathi, Shashank;Dewaker, Varun;Kant, Ruchir;Yadav, Prem Narayan;Srivastava, Ajay Kumar research published 《 Copper-Catalyzed Oxidative [3 + 2]-Annulation of Quinoxalin-2(1H)-one with Oxime Esters toward Functionalized Pyrazolo[1,5-a]quinoxalin-4(5H)-ones as Opioid Receptor Modulators》, the research content is summarized as follows. Pyrazolo[1,5-a]quinoxalin-4(5H)-one derivatives I (R = H, n-Pr, allyl, etc.; R1 = H, 8-F, 8-CO2CH3, etc.; R2 = Me, Ph, 2-naphthyl, etc.; R3 = H, Me, Ph; R2R3 = (CH2)2, (CH2)3, (CH2)4, etc.) as novel opioid receptor modulators have been synthesized via copper-catalyzed oxidative [3 + 2]-annulation of quinoxalin-2(1H)-one and oxime-O-acetates. This hydrazine-free C-C and N-N bond formation strategy starts with the generation of C2N1 synthon using oxime acetate, which reacts in a [3 + 2] manner with quinoxalin-2(1H)-one, followed by oxidative aromatization. The synthesized compounds were tested against opioid receptors, of which eight compounds exhibited an antagonistic effect with EC50 < 5μM at various opioid receptors. Mol. docking studies were performed to identify the binding of active ligands I with hKOR protein. Docking results indicated that compounds I (R = n-Pr; R1 = R3 = H; R2 = Ph), and I (R = allyl; R1 = R3 = H; R2 = Ph) participate in hydrogen bonding with the hydroxyl group of T111 of the active site pocket residue.
1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Name: 4-Bromobenzene-1,2-diamine
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary