Application of 2550-36-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2550-36-9, name is (Bromomethyl)cyclohexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The first step of Scheme 19: To a solution of 4-bromo-3-ethoxycarbonylmethoxy-5-(3-hydroxy-phenyl)-thiophene-2-carboxylic acid methyl ester in DMF was added bromomethyl-cyclohexane (21 muL) and K2CO3 (27.6 mg). The resultant suspension was stirred at room temperature, then heated to 80 C. until the disappearance of the starting material as monitored by TLC. The reaction mixture was cooled to room temperature and diluted with EtOAc, and filtered through a pad of Celite, rinsed with EtOAc. The solvent was removed, the crude product was purified on CombiFlash column eluting with hexane/EtOAc to give the desire product, 4-bromo-3-ethoxycarboxymethoxyl-5-3-cyclohexylmethoxy-phenyl)-thiophene-2-carboxylic acid methyl ester (44 mg, 85%) as a colorless oil. 1H NMR (400 MHz, CHLOROFORM-D) delta ppm 1.2 (m, 8H) 1.8 (m, 6H) 3.8 (d, J=6.3 Hz, 2H) 3.9 (s, 3H) 4.3 (q, J=7.1 Hz, 2H) 4.9 (s, 2H) 7.0 (m, 1H) 7.2 (m, 2H) 7.3 (m, 1H).
The synthetic route of (Bromomethyl)cyclohexane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lee, Jinbo; Wan, Zhao-Kui; Wilson, Douglas P.; Follows, Bruce C.; Kirincich, Steven J.; Smith, Michael J.; Wu, Jun-Jun; Foreman, Kenneth W.; Erbe, David V.; Zhang, Yan-Ling; Xu, Weixin; Tam, Steve Y.; US2005/203087; (2005); A1;,
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