Electric Literature of 348-57-2, A common heterocyclic compound, 348-57-2, name is 1-Bromo-2,4-difluorobenzene, molecular formula is C6H3BrF2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: NHC-PdMNPs nanomagnetic catalyst (0.15 mol% Pd),aryl halide (1.0 mmol), phenylboronic acid (1.1 mmol) andpotassium carbonate (2.2 mmol) were placed in a roundbottomedflask. To the mixture, EtOH:H2O (1:1, 5 mL) wasadded and stirred at 70 C for various times. The progressof the reaction was monitored by TLC. After reaction completion,the mixture was cooled to room temperature andthe NHC-PdMNPs nanomagnetic catalyst was separatedby using an external magnet. To the filtrate, ethyl acetate(10 mL) and water (10 mL) were added. Ethyl acetate layerwas separated from the water layer using a separatory funneland dried with sodium sulphate. The dried ethyl acetatewas concentrated in vacuo and the product was purifiedby column chromatography using n-hexane and ethylacetate as eluents to afford the corresponding products ingood to excellent yields. All the coupling products wereknown molecules and were confirmed by comparing the melting point, 1H NMR and mass spectroscopic data withthe authentic samples.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Vishal; Fahlman, Bradley D.; Sasidhar; Patil, Shivaputra A.; Patil, Siddappa A.; Catalysis Letters; vol. 147; 4; (2017); p. 900 – 918;,
Bromide – Wikipedia,
bromide – Wiktionary