Organic compounds having carbon bonded to bromine are called organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: 3-Bromobenzoic acid.
Vanjare, Balasaheb D.;Choi, Nam Gyu;Eom, Young Seok;Raza, Hussain;Hassan, Mubashir;Lee, Ki Hwan;Kim, Song Ja research published 《 Synthesis, carbonic anhydrase inhibition, anticancer activity, and molecular docking studies of 1,3,4-oxadiazole derivatives》, the research content is summarized as follows. In this work, various organic compounds possessing 1,3,4-oxadiazole as a core structure and the structure of the newly synthesized target compounds I (X = H, 2-Br, 3-Br, 4-Br; R = Ph, 4-fluorophenyl, pyridin-3-yl, etc.) has been revealed using different anal. approaches such as FT-IR, LCMS, and NMR (proton and carbon), resp. The in vitro carbonic anhydrase potentials of these synthesized 17 different analogs were investigated. The result suggests that compound I (X = H; R = pyridin-3-yl), a 3-pyridine substituted analog with an IC50 of 0.1 μM, was found to have the most potent carbonic inhibitory activity (11-fold more active) than the pos. control (acetazolamide) with an IC50 of 1.1 ± 0.1 μM. Besides, among the series I approved in the identification of four potent carbonic anhydrase inhibitors with the IC50 standards varies from 0.1 to 1.0 ± 0.1 μM. Addnl., the non-competitive behavior for potent compound II was analyzed using the Lineweaver-Burk plot from the kinetic study. Furthermore, the anticancer activity of all the synthesized compounds screened against B16F10 melanoma cells using the MTT assay method. Addnl., the mol. docking studies revealed that II inhibitor shows good binding energy as well as good binding interaction pattern along with enzyme.
Recommanded Product: 3-Bromobenzoic acid, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary