Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 185122-74-1, name is 5-Bromo-2,3-dihydro-1H-inden-1-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Bromo-2,3-dihydro-1H-inden-1-amine
[B]1-(2,2,2-Trifluoro-acetylamino)-cyclopropanecarboxylic acid ((rac)-5-bromo-indan-1-yl)-amide 1-(2,2,2-Trifluoroacetamido)cyclopropanecarboxylic acid (390 mg, 1.98 mmol) and HATU (753 mg, 1.98 mmol) were dissolved in DMF (12 ml), then Et3N (601 mg, 828 mul, 5.94 mmol) was added and the reaction mixture was stirred for 30 minutes. Subsequently, (rac)-5-bromo-indan-1-ylamine (0.42 g, 1.98 mmol), dissolved in DMF (3 ml), was added and the mixture stirred at RT for 15 h. It was then poured into H2O (50 ml) and extracted with CH2Cl2 (2*25 ml). The organic layers were dried over MgSO4, filtered and concentrated in vacuo to give a crude product (0.876 g) which was purified by flash chromatography (silica gel, 20 g, 0% to 5% MeOH in CH2Cl2) to give the title compound (0.64 g, 83%) as light brown oil. MS: 389.0 (M-H-, 1Br).
The synthetic route of 185122-74-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Aebi, Johannes; Binggeli, Alfred; Hertel, Cornelia; Konkar, Anish Ashok; Kuehne, Holger; Kuhn, Bernd; Maerki, Hans P.; Wang, Haiyan; US2013/18055; (2013); A1;,
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