Organic compounds having carbon bonded to bromine are called organic bromides. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Synthetic Route of 244205-40-1.
Li, Xin-yang;Qian, Xin-hua;Zhu, Ju;Li, Yu-heng;Lin, Qi-qi;Li, Shuai;Xue, Wen-han;Jian, Ling-yan;Meng, Fan-hao research published 《 Synthesis and evaluation of novel HER-2 inhibitors to exert anti-breast cancer ability through epithelial-mesenchymal transition (EMT) pathway》, the research content is summarized as follows. In this study, two series of (E)-N-((2-(4-(trifluoromethyl)styryl)oxazol-4-yl)methyl)anilines I [R = H, 2-F, 3-Br, etc.] and (E)-4-((5-phenyl-1H-indol-1-yl)methyl)-2-(4-(trifluoromethyl)styryl)azoles II synthesized and tested as novel HER-2 inhibitors to exert anti-breast cancer ability through epithelial-mesenchymal transition (EMT) pathway. Herein, screened out the most potential compound I [R = 4-Br] with HER-2 pos. breast cancer cells through MTT assays, which possessed low toxicity on normal cells (MCF7-10A). Subsequently, wound healing, transwell, western blotting, and immunofluorescence experiments were performed, and it was found that compound compound I [R = 4-Br] could suppress cell migration by inhibiting the phosphorylation of HER-2 and affecting the expression of EMT-related proteins. Moreover, the SKBR3 orthotopic xenograft model confirmed that compound I [R = 4-Br] was more effective than Mubritinib in inhibiting the proliferation of cancer cells. In general, compound I [R = 4-Br] was a potential HER-2 inhibitor in treating breast cancer, which may be of great significance for developing and improving HER-2 small mol. inhibitors.
Synthetic Route of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary