Related Products of 202865-83-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202865-83-6, name is 1-Bromo-3-fluoro-5-methylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To an oven-dried 5 mL screw-capped vial, N-(5-chloroquinolin-8-yl)butyramide (1a) (75 mg, 0.3mmol), heptafluoroisopropyl iodide (178 mg, 0.60 mmol), Pd(OAc)2 (6.7 mg, 0.03 mmol),1-AdCOOH (10.8 mg, 0.06 mmol), K2CO3 (124 mg, 0.9 mmol), toluene (276 mg, 3.0 mmol) andchlorobenzene (0.7 mL) were added in a glove box. The mixture was stirred for 48 h at 140 Cfollowed by cooling. The resulting mixture was filtered through a celite pad and concentrated invacuo. The residue was purified by column chromatography on silica gel (eluent: hexane/EtOAc=2/1) to afford the desired alkylated product 2a (61 mg, 60%) as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-fluoro-5-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kubo, Teruhiko; Aihara, Yoshinori; Chatani, Naoto; Chemistry Letters; vol. 44; 10; (2015); p. 1365 – 1367;,
Bromide – Wikipedia,
bromide – Wiktionary