Adding a certain compound to certain chemical reactions, such as: 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67567-26-4, Safety of 4-Bromo-2,6-difluoroaniline
a) 2,6-DifIuoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline A solution of 4-bromo-2,6-difluoroaniline (2.50 g, 12.02 mmol, 1.0 eq), bis(pinacolato)diboron (3.36 g, 13.22 mmol, 1.1 eq), Pd(dppf)CI2 (150 mg, 0.18 mmol, 15 mol %) and potassium acetate (3.54 g, 36.06 mmol, 3.0 eq) in DMSO was heated at 80C under nitrogen for 90 minutes. The reaction mixture was partitioned between EtOAc (100 mL) and saturated aqueous bicarbonate (100 ml_). The organic layer was washed with brine (3 x 100 mL), dried over MgS04 and concentrated in vacuo to give a brown solid (3.0 g, 97%); H NMR (400 MHz, DMSO-d6) delta ppm 6.94-7.07 (m, 2H), 5.66 (s, 2H), 1.17-1.28 (m, 12H); m/z (ES+APCI)+: 256 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2,6-difluoroaniline, and friends who are interested can also refer to it.
Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; OSBORNE, Simon; CHAPMAN, Timothy; WALLACE, Claire; WO2012/127212; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary