Reference of 13633-25-5, These common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The reaction mixture of 28 (0.50 g, 1.5 mmol) and (4-bromobutyl)benzene (36) (0.34 ml, 2.0 mmol) in dry 1,4-dioxane (16 ml) was stirred for 4 days to afford the title compound as a white solid in 90% yield (0.66 g). mp: 224-225 C; 1H-NMR (400 MHz, DMSO-d6): delta = 7.19-7.39 (m, 15H), 6.76 (s, 1H), 5.20 (brs, 1H), 3.80 (m, 1H), 3.31-3.40 (m, 3H), 3.18 (m, 3H), 2.95 (m, 1H), 2.60 (m, 2H), 2.25 (brs, 1H), 1.55-1.91 (m, 8H); 13C-NMR (100 MHz, DMSO-d6): delta = 172.3, 143.0, 141.4, 128.3, 127.8, 127.7, 127.1, 127.0, 126.0, 80.7, 68.6, 66.3, 62.6, 59.3, 52.6, 34.4, 27.7, 20.8, 17.6; HRMS calcd. for C31H36N1O3 [M]+: 470.2695; found: m/z = 470.2691; HPLC (Method A): tR (min) = 9.15 (96%).
The synthetic route of 13633-25-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yamashita, Yasunobu; Tanaka, Ken-ichiro; Yamakawa; Asano; Kanda, Yuki; Takafuji; Kawahara, Masahiro; Takenaga, Mitsuko; Fukunishi, Yoshifumi; Mizushima; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3339 – 3346;,
Bromide – Wikipedia,
bromide – Wiktionary