Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Category: bromides-buliding-blocks.
Gao, Xiu-zheng;Lv, Xu-tao;Zhang, Rui-rui;Luo, Yang;Wang, Mu-xuan;Chen, Jia-shu;Zhang, Yu-kai;Sun, Bin;Sun, Jin-yue;Liu, Yu-fa;Liu, Chao research published 《 Design, synthesis and in vitro anticancer research of novel tetrandrine and fangchinoline derivatives》, the research content is summarized as follows. Cancer treatment is one of the major public health issues in the world. Tetrandrine (Tet) and fangchinoline (d-Tet) are two bis-benzyl isoquinoline alkaloids extracted from Stephania tetrandra S. Moore, and their antitumor activities have been confirmed. However, the ED of Tet and d-Tet were much higher than that of the pos. control and failed to meet clin. standards Therefore, in this study, as a continuation of our previous work to study and develop high-efficiency and low-toxic antitumor lead compounds, twenty new Tet and d-Tet derivatives were designed, synthesized and evaluated as antitumor agents against six cancer cell lines (H460, H520, HeLa, HepG-2, MCF-7, SW480 cell lines) and BEAS-2B normal cells by CCK-8 anal. Ten derivatives showed better cytotoxic effects than the parent fangchinoline, of which I showed the strongest cell growth inhibitory activity with an IC50 value of 0.59μM against A549 cells. Subsequently, the antitumor mechanism of I was studied by flow cytometry, Hoechst 33258, JC-1 staining, cell scratch, transwell migration, and Western blotting assays. These results showed that compound I could inhibit A549 cell proliferation by arresting the G2/M cell cycle and inhibiting cell migration and invasion by reducing MMP-2 and MMP-9 expression. Meanwhile, I could induce apoptosis of A549 cells through the intrinsic pathway regulated by mitochondria. In addition, compound I inhibited the phosphorylation of PI3K, Akt and mTOR, suggesting a correlation between blocking the PI3K/Akt/mTOR pathway and the above antitumor activities. These results suggest that compound I may be a future drug for the development of new potential drug candidates against lung cancer.
Category: bromides-buliding-blocks, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.
3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.
3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary