One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Synthetic Route of 4897-84-1
Diaz-Peralta, Lucero;Razo-Hernandez, Rodrigo Said;Pastor, Nina;Santiago, Angel;Guevara-Salazar, Juan Alberto;Fernandez-Zertuche, Mario research published 《 1,4-Disubstituted-1,2,3-triazole GABA Analogues: Synthesis, In-Vitro Evaluation, Quantum QSAR and Molecular Docking against Pseudomonas fluorescens GABA-AT》, the research content is summarized as follows. The synthesis of a new series of γ-aminobutyric acid (GABA) analogs was reported where the nitrogen at the γ-position contained in a 1,4-disubstituted-1,2,3-triazole ring system. The triazole ring system was assembled by the Cu(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuACC) protocol. Two compounds were identified two active compounds with 43 and 59% inhibition resp. A descriptive quantum QSAR study was carried out to correlate this activity with the structural changes in the GABA scaffold. The inhibitory activity of the compounds was related to the electronic properties of the triazole ring and substituents. The interaction with P. fluorescens GABA-aminotransferase (GABA-AT) was evaluated by mol. docking, using a homol. model of the biol. target. One compound showed the best interaction energy, the thiophene- substituted triazole, with a value that correlates well with the exptl. inhibition results. The triazole ring is determinant for a proper orientation for interaction with the GABA-AT enzyme. In addition, the mol. docking revealed the importance of a hydrophobic pocket near the PLP prosthetic group and how this pocket can be used to improve the inhibitory activity of GABA analogs. Human GABA-AT mol. docking studies of these analogs showed their great potential as competitive inhibitors of this enzyme.
Synthetic Route of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary