In 2017,Yoon, Dong-Oh; Zhao, Xiaodi; Son, Dohyun; Han, Jung Tae; Yun, Jaesook; Shin, Dongyun; Park, Hyun-Ju published 《SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists》.ACS Medicinal Chemistry Letters published the findings.Name: 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:
G-protein coupled receptor 40 (GPR40) has been considered to be an attractive drug target for the treatment of type 2 diabetes because of its role in free fatty acids-mediated enhancement of glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. A series of indole-5-propanoic acid compounds were synthesized, and their GPR40 agonistic activities were evaluated by nuclear factor of activated T-cells reporter assay and GSIS assay in the MIN-6 insulinoma cells. Three compounds, 8h (3-(2-(2-chlorophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 58.6 nM), 8i (3-(2-(3-chlorophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 37.8 nM), and 8o (3-(2-(2-bromophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 9.4 nM), were identified as potent GPR40 agonists with good GSIS effects. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Name: 1-Bromo-2-isopropylbenzene)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 1-Bromo-2-isopropylbenzene Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary