Formula: C13H17BrO9In 2022 ,《A novel synthesis of tetrahydrocortisone 3-glucuronide》 was published in Journal of Carbohydrate Chemistry. The article was written by Zhang, Yan; Zhang, Suqing; Li, Rui; Shen, Jingshan; Jiang, Xiangrui; Aisa, Haji A.. The article contains the following contents:
A new route for the synthesis of tetrahydrocortisone 3-glucuronide has been developed with cortisone acetate as a starting material. The key step was using lithium tri-tert-butoxyaluminum hydride to reduce the C-3 carbonyl group of 5β-dihydrocortisone acetate to provide 3α-5β-tetrahydrocortisone acetate. Then, Koenig-Knorr method was used for glycosylation with glycosyl bromide as the donor, cadmium carbonate as promoter and 4Å mol. sieves as dehydrating agent to give high yield of the desired product. The new route is shorter and gives higher yield than that reported in the literature. In the part of experimental materials, we found many familiar compounds, such as (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Formula: C13H17BrO9)
(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Formula: C13H17BrO9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary