《Palladium-Catalyzed Olefination of N-Tosylhydrazones as β-Diazo Phosphonate Precursors with Arylhalides》 was written by He, Jing; Feng, Yijiao; Yang, Fang; Dai, Bin; Liu, Ping. Product Details of 2675-79-8 And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:
Palladium-catalyzed reaction of β-ketophosphonate hydrazones R1C(:NNTs)CH2P(O)R22 with halides RX (R1, R = aryl, alkyl; X = halo) affording vinylphosphonates R1RC:CHP(O)R22 as a (Z/E)-mixtures An efficient palladium-catalyzed olefination of N-tosylhydrazones as β-diazo phosphonate precursors with aryl halides has been developed. 2,2-Disubstituted vinylphosphonates bearing versatile functional groups were easily accessed in moderate to excellent yields. Various aryl halides could be employed as the coupling partners, such as (hetero)aryl bromides, aryl iodides, and even aryl chlorides. Moreover, with a similar strategy (2,2-diphenylvinyl)diarylphosphine oxides can also be attained by the reaction of N-tosylhydrazones and aryl bromides. This protocol features easily available raw materials, simple reaction conditions, broad substrate scope as well as scale-up ability. Moreover, the potential application of this product was exemplified by further transformations. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Product Details of 2675-79-8)
1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Product Details of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary