Misra, Raj N.’s team published research in Journal of Medicinal Chemistry in 1991 | CAS: 135613-33-1

Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Synthetic Route of C11H13BrO2

Synthetic Route of C11H13BrO2On September 30, 1991 ,《Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2(TxA2)antagonists. Semicarbazone ω-chains》 was published in Journal of Medicinal Chemistry. The article was written by Misra, Raj N.; Brown, Baerbel R.; Han, Wen Ching; Harris, Don N.; Hedberg, Anders; Webb, Maria L.; Hall, Steven E.. The article contains the following contents:

A series of chiral interphenylene oxabicycloheptane semicarbazones I [n = 1, 2; X = CH2, OCH2, (CH2)2, (CH2)3] were prepared and evaluated for their in vitro thromboxane (TxA2) antagonist activity and in vivo duration of action. The potency of I was highly dependent on the substitution pattern of the interphenylene ring and decreased in the order ortho > meta > para. (S)-I [n = 1; X = (CH2)2 (II)] (SQ 35,091) was identified as a potent and long-acting TxA2 antagonist. In human platelet rich plasma II inhibited arachidonic acid (800 μM) and U-46,619 (10 μM) induced aggregation with T50 values of 3 and 12 nM, resp. In contrast, no inhibition of ADP (20 μM) induced aggregation was observed at >1000 μM. Receptor binding studies with [3H]-SQ 29,548 showed II was a competitive antagonist with a Kd value of 1.0 ± 0.1 nM in human platelet membranes. In vivo II (0.2 mg/kg po) showed extended protection (T50 = 16 h) from U-46,619 (2 mg/kg i.v.) induced death in mice. These compounds have for the 1st time demonstrated that a metabolically stable interphenylene α side chain can be introduced into a prostanoid-like series of TxA2 antagonists with the maintenance of potent antagonist activity. In the experimental materials used by the author, we found Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1Synthetic Route of C11H13BrO2)

Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Synthetic Route of C11H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary