In 2017,Su, Bo; Hartwig, John F. published 《Ir-Catalyzed enantioselective, intramolecular silylation of methyl C-H Bonds》.Journal of the American Chemical Society published the findings.Recommanded Product: 7073-94-1 The information in the text is summarized as follows:
2-Isopropylphenyl hydrosilanes undergo intramol. silylative asym. cyclization, catalyzed by iridium chiral oxazolinylpyridine and oxazolinylquinoline complexes, giving chiral 3-methyl-1-silaindanes with >95% enantioselectivity, the dehydrogenative coupling being promoted by addition of hydrogen acceptors, 3,3-dimethyl-1-butene or norbornene. We report highly enantioselective intramol., silylations of unactivated, primary C(sp3)-H bonds. The reactions form dihydrobenzosiloles in high yields with excellent enantioselectivities by functionalization of enantiotopic Me groups under mild conditions. The reaction is catalyzed by an iridium complex generated from [Ir(COD)OMe]2 and chiral dinitrogen ligands that we recently disclosed. The C-Si bonds in the enantioenriched dihydrobenzosiloles were further transformed to C-Cl, C-Br, C-I, and C-O bonds in final products. The potential of this reaction was illustrated by sequential C(sp3)-H and C(sp2)-H silylations and functionalizations, as well as diastereoselective C-H silylations of a chiral, natural-product derivative containing multiple types of C-H bonds. Preliminary mechanistic studies suggest that C-H cleavage is the rate-determining step. The experimental process involved the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 7073-94-1)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Recommanded Product: 7073-94-1 Organobromine compounds have fallen under increased scrutiny for their environmental impact.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary