Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3972-65-4, name is 1-Bromo-4-(tert-butyl)benzene, A new synthetic method of this compound is introduced below., Computed Properties of C10H13Br
Into a 50 mL seal tube was placed 1-bromo-4-tert-butylbenzene (5.0 g, 23.5 mmol), Pd(PPh3)2Cl2 (660 mg, 0.94 mmol), CuI (47 mg, 0.23 mmol), 10 mL of TEA and 20 mL of toluene. This yellow suspension was degassed by bubbling with nitrogen for 10 min, and then 5.0 mL of (trimethylsilyl)acetylene (3.46 g, 35.2 mmol) was added with a syringe. The seal tube is then immediately sealed under nitrogen atm. and heated to 80C and stirred for 12 h. The reaction mixture was allowed to cool to room temperature and was then filtered through celite. The solids were washed thoroughly with ethyl ether until the washings were colourless and the filtrate was evaporated to dryness under reduced pressure. The residue was purified by column chromatography using hexane as the eluent to give 4 as a pale yellow oil. The 1H-NMR spectrum matched with that of the previously reported compound. 5 Isolated yield (4.0 g, 74%)1H NMR (CDCl3, 300 MHz) : 0.31 (s, 9H), 1.37 (s, 9H), 7.33 (d, 2H, J = 8.7 Hz), 7.41 (d, 2H, J = 8.5 Hz).MS-EI : m/z 230.0 [M]+ .
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Ananth Reddy; Thomas, Anup; Mallesham; Sridhar; Jayathirtha Rao; Bhanuprakash; Tetrahedron Letters; vol. 52; 51; (2011); p. 6942 – 6947;,
Bromide – Wikipedia,
bromide – Wiktionary